{
  "id": 23335,
  "label": "alcohol-induced Wernicke-Korsakoff's syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0044333",
  "properties": {
    "xrefs": [
      "GARD:0027971",
      "MEDGEN:312391",
      "NCIT:C34366",
      "UMLS:C1704427"
    ],
    "synonyms": [
      "alcohol-induced Wernicke-Korsakoff's syndrome",
      "alcohol-induced amnestic syndrome",
      "alcoholic Korsakoff's psychosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A syndrome which occurs in individuals with a history of alcohol abuse. It is caused by prolonged alcohol-induced neurological damage and malnutrition including vitamin and electrolyte deficiencies. Clinical signs include altered mental status, visual impairment and decreased muscle coordination. The clinical course varies and is, in part, dependent upon the severity of symptoms at presentation. The prognosis is poor and worsens if alcohol abuse continues."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 11379,
      "label": "Wernicke-Korsakoff syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        8312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10915",
          "EFO:1001242",
          "GARD:0027793",
          "MEDGEN:83883",
          "MESH:C538669",
          "MedDRA:10047913",
          "NCIT:C35764",
          "OMIM:277730",
          "SCTID:69482004",
          "UMLS:C0349464",
          "icd11.foundation:2017611840"
        ],
        "synonyms": [
          "Wernicke-Korsakoff syndrome",
          "Wernicke encephalopathy",
          "alcohol-induced encephalopathy",
          "transketolase defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Wernicke-Korsakoff syndrome is a brain disorder, due to thiamine deficiency that has been associated with both Wernicke's encephalopathy and Korsakoff syndrome. The term refers to two different syndromes, each representing a different stage of the disease. Wernicke's encephalopathy represents the 'acute' phase and Korsakoff's syndrome represents the 'chronic' phase. However, they are used interchangeable in many sites. Wernicke's encephalopathy is characterized by confusion, abnormal stance and gait (ataxia), and abnormal eye movements (nystagmus). Korsakoff's syndrome is observed in a small number of patients. It is a type of dementia, characterized by memory loss and confabulation (filling in of memory gaps with data the patient can readily recall) and involvement of the heart, vascular, and nervous system. Wernicke-Korsakoff syndrome mainly results from chronic alcohol use, but also from dietary deficiencies, prolonged vomiting, eating disorders, systemic diseases (cancer, AIDS, infections), bariatric surgery, transplants, or the effects of chemotherapy. Studies indicate that there may be some genetic predisposition for the disease.Treatment involves supplementing the diet with thiamine. Wernicke encephalopathy is an acute syndrome and requires emergency treatment to prevent death and neurologic complications. In cases where the diagnosis is not confirmed, patients should still be treated while additional evaluations are completed."
      },
      "child_count": 2,
      "reference_id": "MONDO:0010198"
    },
    {
      "id": 20731,
      "label": "alcohol amnestic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3397,
        20729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001759",
          "MEDGEN:1799",
          "MESH:D000425",
          "SCTID:73097000",
          "UMLS:C0001940"
        ],
        "synonyms": [
          "Dysmnesic psychoses, alcohol-induced",
          "Dysmnesic psychosis, alcohol-induced",
          "Dysmnesic syndrome, alcohol-induced",
          "Dysmnesic syndromes, alcohol-induced",
          "Korsakoff syndrome, alcohol-induced",
          "Korsakoff syndrome, alcoholic",
          "Korsakoff syndromes, alcohol-induced",
          "Korsakoff syndromes, alcoholic",
          "alcohol amnestic disorders",
          "alcohol amnestic syndrome",
          "alcohol amnestic syndromes",
          "alcohol induced Dysmnesic psychosis",
          "alcohol induced Dysmnesic syndrome",
          "alcohol induced Korsakoff syndrome",
          "alcohol induced amnestic psychosis",
          "alcohol induced amnestic syndrome",
          "alcohol induced persisting amnestic disorder",
          "alcohol-induced Dysmnesic psychoses",
          "alcohol-induced Dysmnesic psychosis",
          "alcohol-induced Dysmnesic syndrome",
          "alcohol-induced Dysmnesic syndromes",
          "alcohol-induced Korsakoff syndrome",
          "alcohol-induced Korsakoff syndromes",
          "alcohol-induced amnestic psychoses",
          "alcohol-induced amnestic psychosis",
          "alcohol-induced amnestic syndrome",
          "alcohol-induced amnestic syndromes",
          "alcohol-induced persisting amnestic disorder",
          "alcoholic Korsakoff syndrome",
          "alcoholic Korsakoff syndromes",
          "amnestic disorder, alcohol",
          "amnestic disorders, alcohol",
          "amnestic psychoses, alcohol-induced",
          "amnestic psychosis, alcohol induced",
          "amnestic psychosis, alcohol-induced",
          "amnestic syndrome, alcohol",
          "amnestic syndrome, alcohol-induced",
          "amnestic syndromes, alcohol",
          "amnestic syndromes, alcohol-induced",
          "psychoses, alcohol-induced Dysmnesic",
          "psychoses, alcohol-induced amnestic",
          "psychosis, alcohol-induced Dysmnesic",
          "psychosis, alcohol-induced amnestic",
          "syndrome, alcohol amnestic",
          "syndrome, alcohol-induced Dysmnesic",
          "syndrome, alcohol-induced Korsakoff",
          "syndrome, alcohol-induced amnestic",
          "syndrome, alcoholic Korsakoff",
          "syndromes, alcohol amnestic",
          "syndromes, alcohol-induced Dysmnesic",
          "syndromes, alcohol-induced Korsakoff",
          "syndromes, alcohol-induced amnestic",
          "syndromes, alcoholic Korsakoff"
        ],
        "definition": "A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)"
      },
      "child_count": 2,
      "reference_id": "MONDO:0021702"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 11379,
      "label": "Wernicke-Korsakoff syndrome"
    },
    {
      "id": 20731,
      "label": "alcohol amnestic disorder"
    }
  ]
}