{
  "id": 22822,
  "label": "late-onset familial hypoaldosteronism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0035321",
  "properties": {
    "xrefs": [
      "GARD:0022244",
      "ICD10CM:E27.4",
      "MEDGEN:1843290",
      "Orphanet:556037",
      "UMLS:C5680172"
    ],
    "synonyms": [
      "Late-onset familial hyperreninemic hypoaldosteronism",
      "Mild aldosterone synthase deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A rare form of familial hypoaldosteronism characterized by adult onset of subnormal plasma aldosterone with elevated plasma renin activity, hyperkalemia, metabolic acidosis, and hypotension. Signs and symptoms are typically mild, and affected individuals may be clinically asymptomatic and diagnosed only after biochemical screening."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18558,
      "label": "familial hypoaldosteronism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16605
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016532",
          "MEDGEN:899592",
          "Orphanet:427",
          "SCTID:715343000",
          "UMLS:C4275180",
          "icd11.foundation:712299654"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Aldosterone synthase deficiency is a rare inherited defect of the final step of aldosterone biosynthesis (conversion of deoxycorticosterone to aldosterone)."
      },
      "child_count": 5,
      "reference_id": "MONDO:0018541"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18558,
      "label": "familial hypoaldosteronism"
    }
  ]
}