{
  "id": 22244,
  "label": "thyroid hormone metabolism, abnormal",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0031432",
  "properties": {
    "xrefs": [
      "MEDGEN:355288",
      "OMIMPS:609698",
      "UMLS:C1864761"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6875,
      "label": "endocrine system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:28",
          "EFO:0001379",
          "ICD9:259.8",
          "ICD9:259.9",
          "MEDGEN:4043",
          "MESH:D004700",
          "NANDO:1100009",
          "NANDO:2100109",
          "NCIT:C3009",
          "SCTID:362969004",
          "UMLS:C0014130"
        ],
        "synonyms": [
          "disease of endocrine system",
          "disease or disorder of endocrine system",
          "disorder of endocrine system",
          "endocrine disease",
          "endocrine disorder",
          "endocrine system disease",
          "endocrine system disease or disorder",
          "endocrine system disorder",
          "endocrinopathy",
          "thyroid or other glandular disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the endocrine system."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005151"
    }
  ],
  "children": [
    {
      "id": 22062,
      "label": "thyroid hormone metabolism, abnormal, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        22244
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1812066",
          "OMIM:619855",
          "UMLS:C5676976"
        ],
        "synonyms": [
          "THMA2",
          "thyroid hormone metabolism, abnormal, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030839"
    },
    {
      "id": 24800,
      "label": "thyroid hormone metabolism, abnormal 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16929,
        22244
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017068",
          "MEDGEN:1801974",
          "MESH:C566454",
          "OMIM:609698",
          "Orphanet:171706",
          "UMLS:C5676891"
        ],
        "synonyms": [
          "thyroid hormone metabolism, abnormal",
          "THMA1",
          "short stature-delayed bone age due to thyroid hormone metabolism deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, genetic congenital hypothyroidism disorder characterized by mild global developmental delay in childhood, short stature, delayed bone age, and abnormal thyroid and selenium levels in serum (high total and free T4 concentrations, low T3, high reverse T3, normal to high TSH, decreased selenium). Intellectual disability, primary infertility, hypotonia, muscle weakness, and impaired hearing have also been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800046"
    },
    {
      "id": 25481,
      "label": "thyroid hormone metabolism, abnormal, 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        22244
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1824065",
          "OMIM:620198",
          "UMLS:C5774292"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0859354"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6875,
      "label": "endocrine system disorder"
    }
  ]
}