{
  "id": 20742,
  "label": "Acanthamoeba infectious disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021747",
  "properties": {
    "xrefs": [
      "SCTID:49649001"
    ],
    "synonyms": [
      "Acanthamoeba infection",
      "infection by Acanthamoeba",
      "acanthamoebiasis",
      "acanthamoebosis",
      "infection caused by Acanthamoeba",
      "infections, Acanthamoeba"
    ],
    "definition": "An infectious disease involving the Acanthamoeba."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7200,
      "label": "infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050117",
          "EFO:0005741",
          "ICD10CM:A00-B99",
          "ICD9:079.0",
          "ICD9:136.8",
          "ICD9:136.9",
          "IDO:0000436",
          "MEDGEN:1057",
          "MESH:D003141",
          "NCIT:C26726",
          "SCTID:40733004",
          "UMLS:C0009450"
        ],
        "synonyms": [
          "communicable disease",
          "infection",
          "infectious",
          "infectious disease",
          "infectious diseases and manifestations",
          "infectious disorder",
          "transmissible disease",
          "clinical infection",
          "disease by infectious agent"
        ],
        "definition": "A disorder directly resulting from the presence and activity of a microbial, viral, or parasitic agent in humans. It can be transmitted by direct or indirect contact."
      },
      "child_count": 35,
      "reference_id": "MONDO:0005550"
    }
  ],
  "children": [
    {
      "id": 2819,
      "label": "granulomatous amebic encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        19721,
        20742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050246",
          "GARD:0012651",
          "ICD9:323.2",
          "MEDGEN:572559",
          "SCTID:230187000",
          "UMLS:C0338428"
        ],
        "synonyms": [
          "Acanthamoeba encephalitis",
          "Acanthamoeba granulomatous encephalitis",
          "granulomatous amebic encephalitis due to Acanthamoeba"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Granulomatous amebic encephalitis is a life-threatening infection of the brain caused by the free-living amoebae Acanthamoeba spp., Balamuthia mandrillaris and Sappinia pedata. Acanthamoeba species, are commonly found in lakes, swimming pools, tap water, and heating and air conditioning units. The disease affects immunocompromised people and is very serious. Symptoms include mental status changes, loss of coordination, fever, muscular weakness or partial paralysis affecting one side of the body, double vision, sensitivity to light and other neurologic problems. The diagnosis is difficult and is often made at advanced stages. Tests useful in the diagnosis include brain scans, biopsies, or spinal taps and in disseminated disease, biopsy of the involved sites and testing by the laboratory experts. Early diagnosis is important for the prognosis. No single drug is effective; hence multiple antibiotics are needed for successful treatment. A combination of surgical and medical interventions involving multiple specialty experts is required to prevent death and morbidity in survivors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000291"
    },
    {
      "id": 7268,
      "label": "Acanthamoeba keratitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        20742,
        21277,
        21348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007126",
          "GARD:0009285",
          "ICD9:370.8",
          "MEDGEN:1268",
          "MESH:D015823",
          "MedDRA:10069408",
          "NCIT:C50450",
          "Orphanet:67043",
          "SCTID:231896005",
          "UMLS:C0000880",
          "icd11.foundation:49744193"
        ],
        "synonyms": [
          "Acanthamoeba caused keratitis",
          "keratitis, Acanthamoeba"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Keratitis due to infection by acanthamoeba; it is usually associated with soft contact lens wear, particularly overnight wear."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005629"
    }
  ],
  "roots": [
    {
      "id": 7200,
      "label": "infectious disease"
    }
  ]
}