{
  "id": 20709,
  "label": "ovarian sex cord-stromal tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0021657",
  "properties": {
    "xrefs": [
      "DOID:0080369",
      "GARD:0012285",
      "MEDGEN:154644",
      "NCIT:C4862",
      "ONCOTREE:SCST",
      "UMLS:C0600113"
    ],
    "synonyms": [
      "Sex cord-stromal neoplasm of ovary",
      "Sex cord-stromal neoplasm of the ovary",
      "Sex cord-stromal tumor of ovary",
      "Sex cord-stromal tumor of the ovary",
      "Sex cord-stromal tumour of ovary",
      "Sex cord-stromal tumour of the ovary",
      "ovarian Sex cord-stromal neoplasm",
      "ovarian Sex cord-stromal tumor",
      "ovarian Sex cord-stromal tumour",
      "ovary sex cord-stromal tumor",
      "ovary sex cord-stromal tumour",
      "sex cord-stromal tumor of ovary",
      "sex cord-stromal tumour of ovary",
      "ovarian sex cord tumor with annular tubules",
      "ovarian sex cord tumour with annular tubules",
      "sex cord stromal tumor",
      "sex cord stromal tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7639,
      "label": "sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:192",
          "EFO:1000052",
          "ICDO:8590/1",
          "MEDGEN:104926",
          "NANDO:2200072",
          "NCIT:C3794",
          "UMLS:C0206724"
        ],
        "synonyms": [
          "Sex cord stromal tumor",
          "Sex cord-stromal neoplasm",
          "Sex cord-stromal tumor",
          "Sex cord-stromal tumor, no ICD-O subtype",
          "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
          "Sex cord-stromal tumour",
          "neoplasm of sex cord",
          "sex cord neoplasm",
          "sex cord tumor",
          "sex cord tumour",
          "sex cord-stromal tumor",
          "specialised gonadal neoplasm",
          "specialised gonadal neoplasm (morphologic abnormality)",
          "specialised gonadal neoplasm NOS (morphologic abnormality)",
          "specialised gonadal tumour",
          "specialised gonadal tumour (qualifier value)",
          "specialized gonadal neoplasm (morphologic abnormality)",
          "specialized gonadal neoplasm NOS (morphologic abnormality)",
          "specialized gonadal tumor (qualifier value)",
          "tumor of sex cord",
          "tumour of sex cord",
          "malignant testicular sex cord-stromal tumor",
          "malignant testicular sex cord-stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm involving a sex cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006055"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003893",
          "ICD9:239.5",
          "MEDGEN:181539",
          "NCIT:C4984",
          "SCTID:123843001",
          "UMLS:C0919267"
        ],
        "synonyms": [
          "neoplasm of ovary",
          "neoplasm of the ovary",
          "ovarian neoplasm",
          "ovarian tumor",
          "ovarian tumors",
          "ovarian tumour",
          "ovarian tumours",
          "ovary neoplasm",
          "ovary neoplasm (disease)",
          "ovary tumor",
          "ovary tumour",
          "tumor of ovary",
          "tumor of the ovary",
          "tumour of ovary",
          "tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant neoplasm involving the ovary."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021068"
    }
  ],
  "children": [
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18448,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018816",
          "MEDGEN:233667",
          "NCIT:C8053",
          "Orphanet:35808",
          "UMLS:C1334609"
        ],
        "synonyms": [
          "malignant Sex cord-stromal tumor of ovary",
          "malignant Sex cord-stromal tumor of the ovary",
          "malignant Sex cord-stromal tumour of ovary",
          "malignant Sex cord-stromal tumour of the ovary",
          "malignant ovarian SCST",
          "malignant ovarian Sex cord-stromal neoplasm",
          "malignant ovarian Sex cord-stromal tumor",
          "malignant ovarian Sex cord-stromal tumour",
          "malignant ovarian sex cord-stromal tumor",
          "malignant ovarian sex cord-stromal tumour",
          "ovarian sex cord-stromal tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018172"
    },
    {
      "id": 19984,
      "label": "ovarian gynandroblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009665",
          "ICDO:8632/1",
          "MEDGEN:83412",
          "MESH:C538459",
          "NCIT:C3072",
          "Orphanet:99914",
          "SCTID:254867003",
          "UMLS:C0346178"
        ],
        "synonyms": [
          "Gynandroblastoma of ovary",
          "Gynandroblastoma of the ovary",
          "Gynandroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare neoplasm arising from the ovary. Although it may occur at any age, it is more often seen in young females. Morphologically, it is characterized by a mixture of two cellular populations: well differentiated Sertoli cells and granulosa cells, with the latter constituting at least ten percent of the neoplasm. The vast majority of cases are stage I lesions at presentation and produce either estrogenic or androgenic manifestations. Although it may present as a massive ovarian tumor, it usually follows a benign clinical course. Very rare case reports of testicular lesions morphologically resembling gynandroblastomas are in fact variants of juvenile granulose cell tumor, or Sertoli cell tumor, or a combination of both."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020540"
    },
    {
      "id": 20204,
      "label": "ovarian sertoli-stromal cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027876",
          "MEDGEN:309515",
          "NCIT:C39966",
          "UMLS:C1518732"
        ],
        "synonyms": [
          "Ovarian Sertoli-Stromal Cell Tumor",
          "Ovarian Sertoli-Stromal Cell Tumour",
          "Ovarian Sertoli-Stromal Tumor",
          "Ovarian Sertoli-Stromal Tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor that arises from the ovary and is composed entirely of, or in various combinations of, Sertoli cells, Leydig cells, and fibroblast-like cells."
      },
      "child_count": 1,
      "reference_id": "MONDO:0020807"
    },
    {
      "id": 21206,
      "label": "ovarian granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7622,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027911",
          "MEDGEN:277970",
          "MESH:C537296",
          "NCIT:C6261",
          "SCTID:254863004",
          "UMLS:C1370419"
        ],
        "synonyms": [
          "granulosa cell neoplasm of ovary",
          "granulosa cell neoplasm of the ovary",
          "granulosa cell tumor of ovary",
          "granulosa cell tumor of the ovary",
          "granulosa cell tumour of ovary",
          "granulosa cell tumour of the ovary",
          "ovarian granulosa cell neoplasm",
          "ovarian granulosa cell tumor",
          "ovary granulosa cell tumor",
          "ovary granulosa cell tumour",
          "GCT of the ovary",
          "adult granulosa cell tumor of the ovary",
          "adult granulosa cell tumour of the ovary",
          "granulosa theca cell tumor",
          "granulosa theca cell tumor of the ovary",
          "granulosa theca cell tumour",
          "granulosa theca cell tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0023283"
    },
    {
      "id": 21393,
      "label": "benign ovarian sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3047,
        20709,
        21634
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080370",
          "GARD:0027915",
          "MEDGEN:231435",
          "NCIT:C6803",
          "UMLS:C1332528"
        ],
        "synonyms": [
          "Sex cord stromal tumor, benign",
          "benign Sex cord-stromal neoplasm of ovary",
          "benign Sex cord-stromal neoplasm of the ovary",
          "benign Sex cord-stromal tumor of ovary",
          "benign Sex cord-stromal tumor of the ovary",
          "benign Sex cord-stromal tumour of ovary",
          "benign Sex cord-stromal tumour of the ovary",
          "benign ovarian Sex cord-stromal neoplasm",
          "benign ovarian Sex cord-stromal tumor",
          "benign ovarian Sex cord-stromal tumour",
          "ovarian SEX cord-stromal tumor, benign",
          "ovarian sex cord-stromal tumor, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor arising from the ovary, without metastatic potential."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024387"
    },
    {
      "id": 22961,
      "label": "ovarian thecoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        20709,
        22960
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027955",
          "MEDGEN:364155",
          "NCIT:C66989",
          "SCTID:254864005",
          "UMLS:C1882229"
        ],
        "synonyms": [
          "ovarian theca cell neoplasm",
          "ovarian theca cell tumor",
          "ovarian theca cell tumour",
          "ovarian thecoma",
          "ovary thecoma",
          "theca cell neoplasm of ovary",
          "theca cell neoplasm of the ovary",
          "theca cell tumor of ovary",
          "theca cell tumor of the ovary",
          "theca cell tumour of ovary",
          "theca cell tumour of the ovary",
          "thecoma of ovary",
          "thecoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A stromal tumor that arises from the ovary and is characterized by the presence of cells that contain lipid and resemble theca cells. The vast majority of cases are benign."
      },
      "child_count": 0,
      "reference_id": "MONDO:0037253"
    }
  ],
  "roots": [
    {
      "id": 7639,
      "label": "sex cord-stromal tumor"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm"
    }
  ]
}