{ "id": 20161, "label": "skin squamous cell carcinoma in situ", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0020760", "properties": { "xrefs": [ "MEDGEN:378389", "NCIT:C2906", "UMLS:C2314897" ], "synonyms": [ "intraepidermal squamous cell carcinoma", "skin squamous cell cancer in situ", "skin squamous cell carcinoma in situ", "squamous cell carcinoma in situ of skin", "squamous cell carcinoma in situ of the skin" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "Intraepidermal squamous cell carcinoma, confined to the epidermis. There is no evidence of invasion." }, "isLeaf": false, "isRoot": false, "child_count": 1, "parents": [ { "id": 4598, "label": "skin squamous cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4707, 6823 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3151", "MEDGEN:107512", "NCIT:C4819", "ONCOTREE:CSCC", "SCTID:254651007", "UMLS:C0553723", "icd11.foundation:1448983042" ], "synonyms": [ "cutaneous squamous cell carcinoma", "epidermoid carcinoma of skin", "epidermoid carcinoma of the skin", "epidermoid skin carcinoma", "skin squamous cell cancer", "skin squamous cell carcinoma", "squamous cell carcinoma - skin", "squamous cell carcinoma of skin", "squamous cell carcinoma of the skin", "squamous cell skin carcinoma", "zone of skin squamous cell carcinoma", "CSCC" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated." }, "child_count": 18, "reference_id": "MONDO:0002529" }, { "id": 6427, "label": "skin carcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 4707, 6433 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8687", "ICD10CM:D04", "ICD9:232", "ICD9:232.0", "ICD9:232.2", "ICD9:232.3", "ICD9:232.4", "ICD9:232.5", "ICD9:232.6", "ICD9:232.7", "ICD9:232.8", "ICD9:232.9", "MEDGEN:102308", "NCIT:C3640", "SCTID:92749008", "UMLS:C0154073" ], "synonyms": [ "carcinoma in situ of skin", "carcinoma in situ of the skin", "carcinoma in situ of zone of skin", "carcinoma of skin stage 0", "carcinoma of the skin stage 0", "cutaneous carcinoma in situ", "nonmelanoma carcinoma in situ", "skin cancer stage 0", "skin carcinoma in situ", "skin carcinoma stage 0", "stage 0 nonmelanoma skin carcinoma in situ", "stage 0 skin cancer", "stage 0 skin cancer aJCC v6", "stage 0 skin cancer aJCC v7", "stage 0 skin carcinoma", "stage 0 zone of skin carcinoma", "zone of skin carcinoma in situ", "zone of skin in situ carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A in situ carcinoma that involves the zone of skin." }, "child_count": 2, "reference_id": "MONDO:0004641" }, { "id": 6473, "label": "squamous carcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 6433, 6823 ], "type_id": 0, "properties": { "xrefs": [ "ICDO:8070/2", "ICDO:8077/2", "MEDGEN:83116", "NCIT:C27093", "UMLS:C0334245" ], "synonyms": [ "carcinoma, squamous cell, in situ, malignant", "epidermoid carcinoma in situ", "epidermoid cell carcinoma in situ", "grade 3 SIN", "grade 3 squamous intraepithelial neoplasia", "grade III SIN", "grade III squamous intraepithelial neoplasia", "intraepithelial squamous cell carcinoma", "squamous carcinoma in situ", "squamous cell carcinoma in situ", "squamous cell carcinoma in-situ", "stage 0 squamous cell carcinoma", "CIN III", "CIN III - carcinoma in situ of cervix", "CIN III - severe dyskaryosis", "carcinoma in situ of cervix", "carcinoma in situ of uterine cervix", "cervical intraepithelial neoplasia grade III with severe dysplasia", "cervix Ca in situ", "severe dysplasia of cervix", "severe dysplasia of the cervix uteri", "squamous intraepithelial neoplasia, grade III", "stage 0 uterine cervix carcinoma", "uterine cervix in situ carcinoma" ], "definition": "A malignant epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues." }, "child_count": 6, "reference_id": "MONDO:0004693" } ], "children": [ { "id": 20162, "label": "Bowen disease of the skin", "isLeaf": true, "isRoot": false, "parents": [ 20161 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0005948", "ICDO:8081/2", "MEDGEN:14207", "MESH:D001913", "NCIT:C62571", "NORD:868", "UMLS:C0006079" ], "synonyms": [ "Bowen Disease", "Bowen disease", "Bowen disease of the skin", "Bowen's disease of the skin", "Bowens Disease", "Disease, Bowen", "Disease, Bowen's", "intraepidermal squamous cell carcinoma, Bowen type" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. It affects predominantly white males in their 6-8th decades of life. Exposed and non-exposed skin sites are equally affected. UV damage and ingestion of inorganic arsenic may play a role in the development of the disease. On the skin surface, it presents as a single or multiple erythematous, scaly, keratotic patches or plaques. The clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact. Complete surgical removal of the lesion may be curative." }, "child_count": 0, "reference_id": "MONDO:0020761" } ], "roots": [ { "id": 4598, "label": "skin squamous cell carcinoma" }, { "id": 6427, "label": "skin carcinoma in situ" }, { "id": 6473, "label": "squamous carcinoma in situ" } ] }