{
  "id": 19763,
  "label": "stromal corneal dystrophy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0020213",
  "properties": {
    "xrefs": [
      "DOID:0060442",
      "GARD:0019519",
      "ICD9:371.56",
      "MEDGEN:20973",
      "Orphanet:98626",
      "SCTID:231931001",
      "UMLS:C0038457",
      "icd11.foundation:1392780216"
    ],
    "synonyms": [
      "corneal dystrophy (disease) of substantia propria of cornea",
      "corneal stromal dystrophy",
      "substantia propria of cornea corneal dystrophy (disease)",
      "stromal dystrophy"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "The stromal corneal dystrophies refer to a group of rare genetically determined corneal dystrophies (CDs) characterized by lesions affecting the corneal stroma, and variable effects on vision depending on the type of dystrophy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 18261,
      "label": "corneal dystrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3211
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2566",
          "GARD:0027867",
          "HP:0001131",
          "ICD9:371.5",
          "ICD9:371.50",
          "MEDGEN:3619",
          "MESH:D003317",
          "MedDRA:10011005",
          "NCIT:C34513",
          "Orphanet:34533",
          "SCTID:5587004",
          "UMLS:C0010036",
          "icd11.foundation:1291475891"
        ],
        "synonyms": [
          "corneal dystrophy",
          "corneal dystrophy (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "The term corneal dystrophy embraces a heterogeneous group of bilateral genetically determined non-inflammatory corneal diseases that are usually restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value."
      },
      "child_count": 13,
      "reference_id": "MONDO:0018102"
    }
  ],
  "children": [
    {
      "id": 6468,
      "label": "lattice corneal dystrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8943",
          "GARD:0024087",
          "HP:0001149",
          "ICD10CM:H18.54",
          "ICD9:277.39",
          "ICD9:357.4",
          "MEDGEN:56355",
          "SCTID:1192004",
          "UMLS:C0155127",
          "icd11.foundation:1247885635"
        ],
        "synonyms": [
          "lattice corneal dystrophy",
          "lattice corneal dystrophy (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0004686"
    },
    {
      "id": 8767,
      "label": "Schnyder corneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060456",
          "GARD:0009277",
          "MEDGEN:124391",
          "MESH:C535475",
          "OMIM:121800",
          "Orphanet:98967",
          "SCTID:419395007",
          "UMLS:C0271287"
        ],
        "synonyms": [
          "SCCD",
          "SCD",
          "Schnyder corneal dystrophy",
          "Schnyder crystalline corneal dystrophy",
          "Schnyder crystalline dystrophy sine crystals",
          "corneal dystrophy, Schnyder type",
          "crystalline stromal dystrophy",
          "hereditary crystalline stromal dystrophy of Schnyder",
          "corneal dystrophy, Schnyder",
          "corneal dystrophy, crystalline, of Schnyder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Schnyder corneal dystrophy (SCD) is a rare form of stromal corneal dystrophy characterized by corneal clouding or crystals within the corneal stroma, and a progressive decrease in visual acuity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007374"
    },
    {
      "id": 8769,
      "label": "fleck corneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060448",
          "GARD:0016879",
          "ICD9:371.56",
          "MEDGEN:287065",
          "MESH:C563256",
          "OMIM:121850",
          "Orphanet:98970",
          "SCTID:417183007",
          "UMLS:C1562113",
          "icd11.foundation:607143324"
        ],
        "synonyms": [
          "FCD",
          "FranC'ois-Neetens speckled corneal dystrophy",
          "François-Neetens speckled corneal dystrophy",
          "corneal fleck dystrophy",
          "fleck corneal dystrophy",
          "Cfd",
          "corneal dystrophy, FLECK",
          "corneal dystrophy, Francois-Neetens speckled or flecked"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Fleck corneal dystrophy (FCD) is a rare generally asymptomatic form of stromal corneal dystrophy characterized by multiple asymptomatic, non-progressive opacities disseminated throughout the corneal stroma with no effect on visual acuity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007376"
    },
    {
      "id": 8770,
      "label": "granular corneal dystrophy type I",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3131,
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080530",
          "GARD:0009677",
          "MEDGEN:351521",
          "MESH:C537304",
          "OMIM:121900",
          "Orphanet:98962",
          "SCTID:419039007",
          "UMLS:C1641846"
        ],
        "synonyms": [
          "GCD1",
          "GCDI",
          "classic GCD",
          "classic granular corneal dystrophy",
          "corneal dystrophy Groenouw type I",
          "granular corneal dystrophy type 1",
          "CDGG1",
          "Groenouw type I corneal dystrophy",
          "corneal dystrophy granular type",
          "corneal dystrophy punctate or nodular",
          "corneal dystrophy, Groenouw type 1",
          "corneal dystrophy, Groenouw type I",
          "corneal dystrophy, punctate or nodular",
          "granular corneal dystrophy, type 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Type I granular corneal dystrophy (GCDI) is a rare form of stromal corneal dystrophy characterized by multiple small deposits in the superficial central corneal stroma, and progressive visual impairment, which may sometimes be severe."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007377"
    },
    {
      "id": 10271,
      "label": "central cloudy dystrophy of François",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19763,
        19764
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016881",
          "MEDGEN:302006",
          "MESH:C563262",
          "OMIM:217600",
          "Orphanet:98972",
          "SCTID:419074008",
          "UMLS:C1622427"
        ],
        "synonyms": [
          "CCDF",
          "central cloudy corneal dystrophy of François",
          "central cloudy dystrophy of Francois",
          "central cloudy dystrophy of François",
          "corneal dystrophy, central type"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Central cloudy dystrophy of François is a very rare form of stromal corneal dystrophy characterized by polygonal or rounded stromal opacities surrounded by clear tissue, and generally no effect on vision."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009018"
    },
    {
      "id": 10273,
      "label": "macular corneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19763,
        19765
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2565",
          "GARD:0006953",
          "ICD10CM:H18.55",
          "ICD9:371.55",
          "MEDGEN:351514",
          "MESH:C537834",
          "MedDRA:10025406",
          "NCIT:C34793",
          "OMIM:217800",
          "Orphanet:98969",
          "SCTID:60258001",
          "UMLS:C1636149",
          "icd11.foundation:791344343"
        ],
        "synonyms": [
          "Fehr corneal dystrophy",
          "MCD",
          "corneal dystrophy Groenouw type II",
          "macular corneal dystrophy",
          "Groenouw type 2 corneal dystrophy",
          "Groenouw type II corneal dystrophy",
          "Mcdc1",
          "Mcdc1, formerly",
          "corneal dystrophy, macular type",
          "macular corneal dystrophy type 1",
          "macular corneal dystrophy, type 1",
          "macular corneal dystrophy, type 2",
          "macular dystrophy, corneal",
          "macular dystrophy, corneal type 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Macular corneal dystrophy (MCD) is a rare, severe form of stromal corneal dystrophy characterized by bilateral ill-defined cloudy regions within a hazy stroma, and eventually severe visual impairment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009020"
    },
    {
      "id": 12936,
      "label": "granular corneal dystrophy type II",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3131,
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060444",
          "GARD:0009278",
          "ICD9:371.56",
          "MEDGEN:220900",
          "MESH:C535474",
          "OMIM:607541",
          "Orphanet:98963",
          "SCTID:397568004",
          "UMLS:C1275685"
        ],
        "synonyms": [
          "Avellino corneal dystrophy",
          "CGD2",
          "GCD2",
          "GCDII",
          "avellino corneal dystrophy",
          "combined granular-lattice corneal dystrophy",
          "granular corneal dystrophy type 2",
          "granular-lattice corneal dystrophy",
          "ACD",
          "CDA",
          "combined granular-lattice corneal dystrophies",
          "corneal dystrophy Avellino type",
          "corneal dystrophy, AVELLINO type",
          "granular and lattice corneal dystrophies",
          "granular corneal dystrophy, type 2",
          "granular-lattice (Avellino) corneal dystrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Type II granular corneal dystrophy (GCDII) is a rare form of stromal corneal dystrophy characterized by irregular-shaped well-demarcated granular deposits in the superficial central corneal stroma, and progressive visual impairment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011855"
    },
    {
      "id": 13452,
      "label": "congenital stromal corneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060445",
          "GARD:0016943",
          "ICD9:371.56",
          "MEDGEN:400601",
          "MESH:C566452",
          "OMIM:610048",
          "Orphanet:101068",
          "SCTID:702359002",
          "UMLS:C1864738",
          "icd11.foundation:1796933876"
        ],
        "synonyms": [
          "CSCD",
          "Witschel dystrophy",
          "congenital hereditary stromal dystrophy",
          "congenital stromal corneal dystrophy",
          "corneal dystrophy, congenital stromal"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Congenital stromal corneal dystrophy (CSCD) is an extremely rare form of stromal corneal dystrophy characterized by opaque flaky or feathery clouding of the corneal stroma, and moderate to severe visual loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012401"
    },
    {
      "id": 14065,
      "label": "posterior amorphous corneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060452",
          "GARD:0016880",
          "MEDGEN:412567",
          "MESH:C567546",
          "OMIM:612868",
          "Orphanet:98971",
          "SCTID:719296002",
          "UMLS:C2748502",
          "icd11.foundation:347556972"
        ],
        "synonyms": [
          "PACD",
          "posterior amorphous corneal dystrophy",
          "posterior amorphous stromal dystrophy",
          "chromosome 12Q21.33 deletion syndrome",
          "corneal dystrophy, POSTERIOR amorphous"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Posterior amorphous corneal dystrophy (PACD) is a very rare form of stromal corneal dystrophy characterized by irregular amorphous sheet-like opacities in the posterior corneal stroma and in Descemet membrane and mildly impaired vision."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013027"
    },
    {
      "id": 17700,
      "label": "pre-descemet corneal dystrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19763
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021168",
          "ICD9:371.56",
          "MEDGEN:573065",
          "Orphanet:293462",
          "SCTID:231934009",
          "UMLS:C0339282",
          "icd11.foundation:2027634766"
        ],
        "synonyms": [
          "PDCD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Pre-Descemet corneal dystrophy (PDCD) is a rare form of stromal corneal dystrophy characterized by focal, fine, gray opacities in the deep stroma immediately anterior to the Descemet membrane, with no effect on vision."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017392"
    }
  ],
  "roots": [
    {
      "id": 18261,
      "label": "corneal dystrophy"
    }
  ]
}