{
  "id": 19542,
  "label": "acute adrenal insufficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019801",
  "properties": {
    "xrefs": [
      "GARD:0019257",
      "ICD10CM:E27.2",
      "ICD9:255.41",
      "MEDGEN:56227",
      "NCIT:C112840",
      "Orphanet:95409",
      "SCTID:24867002",
      "UMLS:C0151467",
      "icd11.foundation:114442391"
    ],
    "synonyms": [
      "Addisonian crisis",
      "acute adrenal failure",
      "acute adrenocortical insufficiency",
      "adrenal crisis",
      "adrenocortical crisis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A primary adrenal insufficiency caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 16073,
      "label": "primary adrenal insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019802",
          "MEDGEN:854614",
          "MedDRA:10052381",
          "NCIT:C113172",
          "Orphanet:101958",
          "UMLS:C3887896"
        ],
        "synonyms": [
          "Addison's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormonal disorder that occurs when the adrenal glands fail to release adequate amounts of glucocorticoids (cortisol), mineralocorticoids (aldosterone, 11-deoxycorticosterone), and androgens (dehydroepiandrosterone) to meet physiologic needs, despite release of ACTH from the pituitary."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015128"
    },
    {
      "id": 20092,
      "label": "acute disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24492
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:1738",
          "MESH:D000208",
          "SCTID:2704003",
          "UMLS:C0001314"
        ],
        "synonyms": [
          "acute disease",
          "acute diseases",
          "disease, acute"
        ],
        "definition": "Disease having a short and relatively severe course."
      },
      "child_count": 119,
      "reference_id": "MONDO:0020683"
    }
  ],
  "children": [
    {
      "id": 7606,
      "label": "Waterhouse-Friderichsen syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        19542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9931",
          "EFO:0007544",
          "GARD:0009449",
          "ICD10CM:A39.1",
          "ICD9:036.3",
          "MEDGEN:234675",
          "MESH:D014884",
          "MedDRA:10047847",
          "NCIT:C85225",
          "Orphanet:100067",
          "SCTID:36102002",
          "UMLS:C1403891",
          "icd11.foundation:2072098125"
        ],
        "synonyms": [
          "WFS",
          "meningococcal hemorrhagic adrenalitis",
          "Waterhouse–Friderichsen syndrome",
          "fatal pneumococcal Waterhouse-Friderichsen syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006015"
    },
    {
      "id": 18086,
      "label": "bilateral massive adrenal hemorrhage",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021409",
          "MEDGEN:1843030",
          "Orphanet:319205",
          "UMLS:C5679892"
        ],
        "synonyms": [
          "BMAH",
          "bilateral adrenal haemorrhage",
          "bilateral adrenal hemorrhage"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A serious adrenal gland disorder characterized by acute bleeding into both adrenal glands. It is associated with illnesses such as severe sepsis, congestive heart failure, autoimmune etiologies such as antiphospholipid syndrome, the use of anticoagulants; especially in the setting of heparin-induced thrombocytopenia, as well as severe physical stress such as trauma and surgery."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017871"
    }
  ],
  "roots": [
    {
      "id": 16073,
      "label": "primary adrenal insufficiency"
    },
    {
      "id": 20092,
      "label": "acute disease"
    }
  ]
}