{
  "id": 19370,
  "label": "CREST syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0019563",
  "properties": {
    "xrefs": [
      "DOID:0060218",
      "GARD:0025139",
      "MEDGEN:60083",
      "MESH:D017675",
      "MedDRA:10011380",
      "NANDO:1201011",
      "NCIT:C70646",
      "Orphanet:90290",
      "SCTID:31848007",
      "UMLS:C0206138"
    ],
    "synonyms": [
      "lcSSc",
      "calcinosis-Raynaud phenomenon-esophageal involvement-sclerodactyly-telangiectasia syndrome",
      "limited cutaneous Systemic Scleroderma",
      "limited cutaneous Systemic sclerosis",
      "CRST syndrome",
      "CRST syndromes",
      "calcinosis - Raynaud phenomenon - esophageal involvement - sclerodactyly - telangiectasia",
      "calcinosis Raynaud phenomenon sclerodactyly telangiectasia",
      "calcinosis, Raynaud's phenomenon, esophageal dismobility, sclerodactyly, telangiectasia syndrome",
      "calcinosis-Raynaud phenomenon-sclerodactyly-telangiectasia",
      "phenomenon-sclerodactyly-telangiectasia, calcinosis-Raynaud",
      "syndrome, CREST"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "CREST syndrome is a subtype of limited cutaneous systemic sclerosis (lcSSc) whose name is an acronym for the cardinal clinical features of the syndrome: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 16892,
      "label": "limited cutaneous systemic sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6827
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1577",
          "GARD:0001053",
          "MEDGEN:148187",
          "MESH:D045745",
          "NANDO:1201011",
          "Orphanet:220402",
          "SCTID:298285004",
          "SCTID:299276009",
          "UMLS:C0748540"
        ],
        "synonyms": [
          "limited cutaneous systemic scleroderma",
          "limited scleroderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Limited cutaneous systemic sclerosis (lcSSc) is a subtype of systemic sclerosis (SSc) characterized by the association of Raynaud's phenomenon with skin fibrosis limited to the hands, face, feet and forearms."
      },
      "child_count": 1,
      "reference_id": "MONDO:0016358"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 16892,
      "label": "limited cutaneous systemic sclerosis"
    }
  ]
}