{
  "id": 18247,
  "label": "viral hemorrhagic fever",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018087",
  "properties": {
    "xrefs": [
      "GARD:0005494",
      "MEDGEN:9213",
      "MESH:D006482",
      "NCIT:C36170",
      "Orphanet:341",
      "SCTID:240523007",
      "UMLS:C0019104"
    ],
    "synonyms": [
      "haemorrhagic fever",
      "hemorrhagic fever",
      "hemorrhagic fevers",
      "VHF",
      "VHFs",
      "haemorrhagic fevers, viral",
      "viral haemorrhagic fever"
    ],
    "definition": "A viral infectious disease caused by RNA viruses in the Arenaviridae, Bunyaviridae, Filoviridae, or Flaviviridae family, and characterized by a severe multisystem syndrome, with damage to the vascular system and hemorrhaging."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 16,
  "parents": [
    {
      "id": 6834,
      "label": "viral infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:934",
          "EFO:0000763",
          "ICD9:060-066",
          "ICD9:066.9",
          "ICD9:078.89",
          "ICD9:079.99",
          "MESH:D014777",
          "NCIT:C3439",
          "SCTID:34014006"
        ],
        "synonyms": [
          "Viruses caused disease or disorder",
          "Viruses disease or disorder",
          "Viruses infection",
          "Viruses infectious disease",
          "infection, viral",
          "viral disease",
          "viral disorder",
          "viral infection",
          "infections, Viruses"
        ],
        "definition": "Any disease caused by a virus."
      },
      "child_count": 42,
      "reference_id": "MONDO:0005108"
    },
    {
      "id": 24379,
      "label": "hemorrhagic fever",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "NCIT:C36169"
        ],
        "synonyms": [
          "haemorrhagic fever"
        ],
        "definition": "An infectious disease caused by certain viruses or bacteria that can damage the walls of tiny blood vessels, making them leak, and can hamper the blood's ability to clot and cause severe, life-threatening illness."
      },
      "child_count": 2,
      "reference_id": "MONDO:0600002"
    }
  ],
  "children": [
    {
      "id": 7042,
      "label": "Dengue hemorrhagic fever",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7158,
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12206",
          "EFO:0004227",
          "GARD:0024174",
          "ICD10CM:A91",
          "MEDGEN:5506",
          "NCIT:C34683",
          "SCTID:20927009",
          "UMLS:C0019100"
        ],
        "definition": "A serious condition caused by Dengue virus infection. Patients present with an acute febrile illness followed by restlessness, irritability, and bleeding. It may lead to hemorrhagic shock and death."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005358"
    },
    {
      "id": 7287,
      "label": "arenavirus hemorrhagic fever",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7286,
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024214",
          "ICD10CM:A96",
          "ICD9:078.7",
          "MEDGEN:509153",
          "SCTID:73730005",
          "UMLS:C0153112"
        ],
        "synonyms": [
          "arenaviral hemorrhagic fever"
        ],
        "definition": "A viral infectious disease that involves fever and bleeding disorder caused by Arenavirus."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005651"
    },
    {
      "id": 7359,
      "label": "Ebola hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7382,
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4325",
          "EFO:0007243",
          "GARD:0002035",
          "ICD10CM:A98.4",
          "MEDGEN:129219",
          "MESH:D019142",
          "MedDRA:10014071",
          "NCIT:C36171",
          "Orphanet:319218",
          "SCTID:37109004",
          "UMLS:C0282687",
          "icd11.foundation:792755706"
        ],
        "synonyms": [
          "EHF",
          "Ebola",
          "Ebola fever",
          "Ebola virus disease",
          "Ebolavirus caused disease or disorder",
          "Ebolavirus disease or disorder",
          "Ebolavirus infectious disease"
        ],
        "definition": "A viral hemorrhagic fever that is caused by the Ebola virus, which is transmitted by contact with infected animals or humans; it is characterized by high fever, unexplained bleeding, and a high mortality rate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005737"
    },
    {
      "id": 7596,
      "label": "Venezuelan equine encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6880,
        7280,
        18247,
        21351,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9584",
          "EFO:0007534",
          "GARD:0006355",
          "ICD10CM:A92.2",
          "ICD9:066.2",
          "MEDGEN:4036",
          "MESH:D004685",
          "NCIT:C35121",
          "SCTID:417067005",
          "UMLS:C0014078",
          "icd11.foundation:608978790"
        ],
        "synonyms": [
          "Venezuelan equine encephalitis virus caused disease or disorder",
          "Venezuelan equine encephalitis virus disease or disorder",
          "Venezuelan equine encephalitis virus infectious disease",
          "Venezuelan equine fever"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A condition caused by infection by the Venezuelan equine encephalitis virus, which is characterized by headache, fever, myalgia, nausea, and vomiting."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006005"
    },
    {
      "id": 18087,
      "label": "Lujo hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050202",
          "GARD:0021410",
          "MEDGEN:905662",
          "Orphanet:319213",
          "SCTID:716585008",
          "UMLS:C4274433"
        ],
        "synonyms": [
          "Zambian hemorrhagic fever"
        ],
        "definition": "Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017872"
    },
    {
      "id": 18089,
      "label": "Bolivian hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050195",
          "GARD:0021412",
          "ICD10CM:A96.1",
          "MEDGEN:76386",
          "MedDRA:10005932",
          "Orphanet:319229",
          "SCTID:67247008",
          "UMLS:C0282192",
          "icd11.foundation:1780467429"
        ],
        "synonyms": [
          "Machupo hemorrhagic fever"
        ],
        "definition": "Bolivian hemorrhagic fever (BHF), caused by the Machupo virus (MACV), is a severe acute viral hemorrhagic fever characterized by fever, myalgia, and arthralgia followed by hemorrhagic and neurological manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017875"
    },
    {
      "id": 18090,
      "label": "Venezuelan hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050196",
          "GARD:0021413",
          "MEDGEN:508283",
          "Orphanet:319234",
          "SCTID:359673001",
          "UMLS:C0042470",
          "icd11.foundation:356743940"
        ],
        "synonyms": [
          "Guanarito hemorrhagic fever"
        ],
        "definition": "Venezuelan hemorrhagic fever (VHF), caused by the Guanarito virus, is a viral hemorrhagic disease characterized by fever, headache, arthralgia, sore throat, convulsions, and hemorrhagic manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017876"
    },
    {
      "id": 18091,
      "label": "Brazilian hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050197",
          "GARD:0021414",
          "MEDGEN:575736",
          "Orphanet:319239",
          "SCTID:240524001",
          "UMLS:C0343633"
        ],
        "synonyms": [
          "Sabia hemorrhagic fever"
        ],
        "definition": "Brazilian hemorrhagic fever, caused by the Sabia virus (a newly discovered arenavirus), is a viral hemorrhagic fever, believed to originate from Sao Paulo, Brazil, with only 3 reported cases (2 of which were due to laboratory accidents) to date, characterized by fever, nausea vomiting myalgia tremors, and hemorragic manifestations such as conjunctival petechia and haematemesis, leading potentially to shock, coma and death."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017877"
    },
    {
      "id": 18092,
      "label": "Chapare hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050198",
          "GARD:0021415",
          "MEDGEN:900792",
          "Orphanet:319244",
          "SCTID:716584007",
          "UMLS:C4274434"
        ],
        "definition": "Chapare hemorrhagic fever, caused by the Chapare virus (a new arenavirus), discovered from a small outbreak in Cochabamba, Bolivia between 2003 and 2004, is an acute viral hemorrhagic fever characterized by fever, myalgia, arthralgia, and multiple hemorrhagic signs. About a third of untreated cases go on to develop more severe symptoms with delirium, coma and convulsions and death (in one case). No other cases have been reported since."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017878"
    },
    {
      "id": 18093,
      "label": "hantavirus pulmonary syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        6971,
        7400,
        18247,
        21376,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14472",
          "EFO:0007296",
          "GARD:0000069",
          "ICD9:480.8",
          "MEDGEN:66205",
          "MESH:D018804",
          "MedDRA:10019143",
          "NCIT:C84747",
          "NORD:1216",
          "Orphanet:319247",
          "SCTID:120639003",
          "UMLS:C0243025",
          "icd11.foundation:582624609"
        ],
        "synonyms": [
          "HARDS",
          "Hantavirus",
          "Hantavirus-associated respiratory distress syndrome",
          "four corners hantavirus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An infection caused by Hantaviruses. It manifests with flu-like symptoms but it rapidly progresses to life-threatening respiratory problems."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017879"
    },
    {
      "id": 18094,
      "label": "Rift valley fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1328",
          "GARD:0021416",
          "ICD10CM:A92.4",
          "MEDGEN:20589",
          "MESH:D012295",
          "MedDRA:10039143",
          "NCIT:C128419",
          "Orphanet:319251",
          "SCTID:402917003",
          "UMLS:C0035613",
          "icd11.foundation:854137188"
        ],
        "synonyms": [
          "RVF"
        ],
        "definition": "Rift Valley fever (RVF), caused by the Rift Valley fever virus (RVFV), is an arbovirus characterized by a usually self-limiting febrile illness but that in some cases can also manifest with thrombosis, vision loss, hemorrhages and/or neurological symptoms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017880"
    },
    {
      "id": 18095,
      "label": "Kyasanur forest disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7383,
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11320",
          "GARD:0008257",
          "ICD10CM:A98.2",
          "ICD9:065.2",
          "MEDGEN:5982",
          "MESH:D007733",
          "MedDRA:10023505",
          "Orphanet:319254",
          "SCTID:23097003",
          "UMLS:C0022810",
          "icd11.foundation:1288604967"
        ],
        "synonyms": [
          "Kyasanur forest disease virus caused disease or disorder",
          "Kyasanur forest disease virus disease or disorder",
          "Kyasanur forest disease virus infectious disease",
          "Kyasanur hemorrhagic fever",
          "KFD",
          "KFD virus",
          "monkey disease",
          "monkey fever"
        ],
        "definition": "Kyasanura forest disease (KFD), caused by the KFD virus, is an arbovirus characterized by an initial fever, headache and myalgia that can progress to a hemorrhagic disease and that in some cases is followed by a second phase characterized by neurological manifestations."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017881"
    },
    {
      "id": 18096,
      "label": "Omsk hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7383,
        18247,
        21670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:992",
          "GARD:0008254",
          "ICD10CM:A98.1",
          "ICD9:065.1",
          "MEDGEN:9212",
          "MESH:D006481",
          "MedDRA:10030310",
          "Orphanet:319266",
          "SCTID:48113006",
          "UMLS:C0019103",
          "icd11.foundation:946068954"
        ],
        "definition": "Omsk hemorrhagic fever (OHF), caused by Omsk hemorrhagic fever virus (OHFV), is a zoonotic disease characterized by fever, nausea, myalgia and moderately severe hemorrhagic manifestations as well as in some cases meningitis, pneumonia and nephrosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017882"
    },
    {
      "id": 18241,
      "label": "hemorrhagic fever-renal syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018689",
          "MEDGEN:42408",
          "MESH:C535630",
          "MedDRA:10023484",
          "Orphanet:340",
          "UMLS:C0019101",
          "icd11.foundation:1059069619"
        ],
        "synonyms": [
          "Hantavirosis",
          "Hantavirus fever"
        ],
        "definition": "Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne potentially severe hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018081"
    },
    {
      "id": 19953,
      "label": "Marburg hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7382,
        18247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4327",
          "EFO:0007358",
          "GARD:0009444",
          "ICD10CM:A98.3",
          "ICD9:078.89",
          "MEDGEN:9888",
          "MESH:D008379",
          "MedDRA:10026822",
          "NCIT:C84883",
          "Orphanet:99826",
          "SCTID:77503002",
          "UMLS:C0024788",
          "icd11.foundation:696598707"
        ],
        "synonyms": [
          "Green monkey disease",
          "MHF",
          "Marburg disease",
          "Marburg virus disease"
        ],
        "definition": "Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020500"
    },
    {
      "id": 19954,
      "label": "Crimean-Congo hemorrhagic fever",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18247,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12287",
          "GARD:0019690",
          "ICD10CM:A98.0",
          "ICD9:065.0",
          "MEDGEN:6800",
          "MESH:D006479",
          "NCIT:C34682",
          "Orphanet:99827",
          "SCTID:402919000",
          "UMLS:C0019099",
          "icd11.foundation:1562906700"
        ],
        "synonyms": [
          "CCHF",
          "Congo fever",
          "Congo hemorrhagic fever",
          "Congo-Crimean hemorrhagic fever",
          "Crimean hemorrhagic fever",
          "Crimean hemorrhagic fever [CHF Congo virus]",
          "Crimean-Congo haemorrhagic fever"
        ],
        "definition": "Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020501"
    }
  ],
  "roots": [
    {
      "id": 6834,
      "label": "viral infectious disease"
    },
    {
      "id": 24379,
      "label": "hemorrhagic fever"
    }
  ]
}