{
  "id": 18218,
  "label": "familial atrial fibrillation",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0018054",
  "properties": {
    "xrefs": [
      "DOID:0050650",
      "GARD:0009740",
      "MEDGEN:894635",
      "OMIMPS:608583",
      "Orphanet:334",
      "SCTID:715395008",
      "UMLS:C3468561",
      "icd11.foundation:45855978"
    ],
    "synonyms": [
      "hereditary atrial fibrillation (disease)",
      "atrial fibrillation autosomal dominant",
      "atrial fibrillation, familial",
      "autosomal dominant atrial fibrillation"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "An autosomal dominant heart condition that causes disruptions in the heart's normal rhythm. This condition is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 18,
  "parents": [
    {
      "id": 6722,
      "label": "atrial fibrillation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060224",
          "EFO:0000275",
          "HP:0005110",
          "ICD9:427.31",
          "MEDGEN:445",
          "MESH:D001281",
          "NANDO:2100051",
          "NANDO:2200226",
          "NCIT:C50466",
          "SCTID:49436004",
          "UMLS:C0004238",
          "icd11.foundation:171698302"
        ],
        "synonyms": [
          "AF",
          "AFib",
          "atrial fibrillation",
          "atrial fibrillation (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)"
      },
      "child_count": 3,
      "reference_id": "MONDO:0004981"
    },
    {
      "id": 26601,
      "label": "cardiogenetic rhythm disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666,
        24272
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "cardiogenetic rhythm disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any cardiac rhythm disorder with a monogenic etiology that includes, but is not limited to, atrial fibrillation, sick sinus syndrome, progressive cardiac conduction disease, ventricular fibrillation, Brugada syndrome, long QT syndrome, short QT syndrome, tachycardia with fibrillation."
      },
      "child_count": 18,
      "reference_id": "MONDO:1010180"
    }
  ],
  "children": [
    {
      "id": 12938,
      "label": "atrial fibrillation, familial, 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015414",
          "MEDGEN:373232",
          "MESH:C563817",
          "OMIM:607554",
          "UMLS:C1837014"
        ],
        "synonyms": [
          "KCNQ1 familial atrial fibrillation",
          "atrial fibrillation, familial, 3",
          "atrial fibrillation, familial, type 3",
          "familial atrial fibrillation caused by mutation in KCNQ1",
          "ATFB3"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the KCNQ1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011857"
    },
    {
      "id": 13133,
      "label": "atrial fibrillation, familial, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024840",
          "MEDGEN:334469",
          "MESH:C538261",
          "OMIM:608583",
          "UMLS:C1843687"
        ],
        "synonyms": [
          "atrial fibrillation, autosomal dominant",
          "ATFB1",
          "atrial fibrillation, familial, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012066"
    },
    {
      "id": 13230,
      "label": "atrial fibrillation, familial, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015446",
          "MEDGEN:324886",
          "MESH:C563903",
          "OMIM:608988",
          "UMLS:C1837812"
        ],
        "synonyms": [
          "ATFB2",
          "atrial fibrillation, familial, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012167"
    },
    {
      "id": 13717,
      "label": "atrial fibrillation, familial, 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015516",
          "MEDGEN:400041",
          "MESH:C566244",
          "OMIM:611493",
          "UMLS:C1862394"
        ],
        "synonyms": [
          "KCNE2 familial atrial fibrillation",
          "atrial fibrillation, familial, 4",
          "atrial fibrillation, familial, type 4",
          "familial atrial fibrillation caused by mutation in KCNE2",
          "ATFB4"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the KCNE2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012677"
    },
    {
      "id": 13718,
      "label": "atrial fibrillation, familial, 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015517",
          "MEDGEN:369411",
          "MESH:C566932",
          "OMIM:611494",
          "UMLS:C1969099"
        ],
        "synonyms": [
          "ATFB5",
          "atrial fibrillation, familial, 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012678"
    },
    {
      "id": 13856,
      "label": "atrial fibrillation, familial, 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015544",
          "MEDGEN:394252",
          "MESH:C567400",
          "OMIM:612201",
          "UMLS:C2677294"
        ],
        "synonyms": [
          "NPPA familial atrial fibrillation",
          "atrial fibrillation, familial, 6",
          "atrial fibrillation, familial, type 6",
          "familial atrial fibrillation caused by mutation in NPPA",
          "ATFB6"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the NPPA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012816"
    },
    {
      "id": 13868,
      "label": "atrial fibrillation, familial, 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015545",
          "MEDGEN:393658",
          "MESH:C567389",
          "OMIM:612240",
          "UMLS:C2677106"
        ],
        "synonyms": [
          "KCNA5 familial atrial fibrillation",
          "atrial fibrillation, familial, 7",
          "atrial fibrillation, familial, type 7",
          "familial atrial fibrillation caused by mutation in KCNA5",
          "ATFB7"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the KCNA5 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012828"
    },
    {
      "id": 14138,
      "label": "atrial fibrillation, familial, 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015609",
          "MEDGEN:414420",
          "MESH:C567802",
          "OMIM:613055",
          "UMLS:C2751607"
        ],
        "synonyms": [
          "ATFB8",
          "atrial fibrillation, familial, 8"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013100"
    },
    {
      "id": 14543,
      "label": "atrial fibrillation, familial, 9",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015737",
          "MEDGEN:462781",
          "OMIM:613980",
          "UMLS:C3151431"
        ],
        "synonyms": [
          "KCNJ2 familial atrial fibrillation",
          "atrial fibrillation, familial, 9",
          "atrial fibrillation, familial, type 9",
          "familial atrial fibrillation caused by mutation in KCNJ2",
          "ATFB9"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the KCNJ2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013513"
    },
    {
      "id": 14559,
      "label": "atrial fibrillation, familial, 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218,
        26602
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015745",
          "MEDGEN:462814",
          "OMIM:614022",
          "UMLS:C3151464"
        ],
        "synonyms": [
          "SCN5A familial atrial fibrillation",
          "atrial fibrillation, familial, 10",
          "atrial fibrillation, familial, type 10",
          "familial atrial fibrillation caused by mutation in SCN5A",
          "ATFB10"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the SCN5A gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013530"
    },
    {
      "id": 14572,
      "label": "atrial fibrillation, familial, 11",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015747",
          "MEDGEN:481323",
          "OMIM:614049",
          "UMLS:C3279693"
        ],
        "synonyms": [
          "GJA5 familial atrial fibrillation",
          "atrial fibrillation, familial, 11",
          "atrial fibrillation, familial, type 11",
          "familial atrial fibrillation caused by mutation in GJA5",
          "ATFB11"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the GJA5 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013544"
    },
    {
      "id": 14573,
      "label": "atrial fibrillation, familial, 12",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015748",
          "MEDGEN:481325",
          "OMIM:614050",
          "UMLS:C3279695"
        ],
        "synonyms": [
          "ABCC9 familial atrial fibrillation",
          "atrial fibrillation, familial, 12",
          "atrial fibrillation, familial, type 12",
          "familial atrial fibrillation caused by mutation in ABCC9",
          "ATFB12"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the ABCC9 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013545"
    },
    {
      "id": 15162,
      "label": "atrial fibrillation, familial, 13",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015954",
          "MEDGEN:815641",
          "OMIM:615377",
          "UMLS:C3809311"
        ],
        "synonyms": [
          "SCN1B familial atrial fibrillation",
          "atrial fibrillation, familial, 13",
          "atrial fibrillation, familial, type 13",
          "familial atrial fibrillation caused by mutation in SCN1B",
          "ATFB13"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the SCN1B gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014155"
    },
    {
      "id": 15163,
      "label": "atrial fibrillation, familial, 14",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015955",
          "MEDGEN:815642",
          "OMIM:615378",
          "UMLS:C3809312"
        ],
        "synonyms": [
          "SCN2B familial atrial fibrillation",
          "atrial fibrillation, familial, 14",
          "atrial fibrillation, familial, type 14",
          "familial atrial fibrillation caused by mutation in SCN2B",
          "ATFB14"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the SCN2B gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014156"
    },
    {
      "id": 15342,
      "label": "atrial fibrillation, familial, 15",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016010",
          "MEDGEN:862706",
          "OMIM:615770",
          "UMLS:C4014269"
        ],
        "synonyms": [
          "NUP155 familial atrial fibrillation",
          "atrial fibrillation 15",
          "atrial fibrillation, familial, 15",
          "atrial fibrillation, familial, type 15",
          "familial atrial fibrillation caused by mutation in NUP155",
          "ATFB15"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the NUP155 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014340"
    },
    {
      "id": 15977,
      "label": "atrial fibrillation, familial, 18",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016219",
          "MEDGEN:934603",
          "OMIM:617280",
          "UMLS:C4310636"
        ],
        "synonyms": [
          "ATFB18",
          "MYL4 familial atrial fibrillation",
          "atrial fibrillation, familial, 18",
          "atrial fibrillation, familial, 18; ATFB18",
          "atrial fibrillation, familial, type 18",
          "familial atrial fibrillation caused by mutation in MYL4"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any familial atrial fibrillation in which the cause of the disease is a mutation in the MYL4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015001"
    },
    {
      "id": 24937,
      "label": "atrial fibrillation, familial, 17",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026510",
          "MEDGEN:861997",
          "UMLS:C4013560"
        ],
        "synonyms": [
          "ATFB17"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800345"
    },
    {
      "id": 24941,
      "label": "atrial fibrillation, familial, 16",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026514",
          "MEDGEN:862136",
          "UMLS:C4013699"
        ],
        "synonyms": [
          "ATFB16"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800349"
    }
  ],
  "roots": [
    {
      "id": 6722,
      "label": "atrial fibrillation"
    },
    {
      "id": 26601,
      "label": "cardiogenetic rhythm disorder"
    }
  ]
}