{
  "id": 17503,
  "label": "drug- or toxin-induced pulmonary arterial hypertension",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017149",
  "properties": {
    "xrefs": [
      "EFO:0009192",
      "GARD:0021026",
      "MEDGEN:573792",
      "Orphanet:275786",
      "UMLS:C0340544"
    ],
    "synonyms": [
      "drug- or toxin-induced PAH"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Drug- or toxin-induced pulmonary arterial hypertension (PAH) is a form of pulmonary arterial hypertension (PAH) secondary to the exposition to drugs. Drug- or toxin-induced PAH is characterized by elevated pulmonary arterial resistance leading to right heart failure. Drug or toxin induced PAH is progressive and potentially fatal."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001361",
          "GARD:0007501",
          "MEDGEN:425404",
          "MESH:D000081029",
          "MedDRA:10064911",
          "NANDO:1200425",
          "NANDO:2100103",
          "NANDO:2200298",
          "NORD:1634",
          "Orphanet:182090",
          "Orphanet:422",
          "SCTID:11399002",
          "UMLS:C2973725",
          "icd11.foundation:1931148955"
        ],
        "synonyms": [
          "PAH",
          "pulmonary arterial hypertension",
          "PAH with overt features of venous/capillaries involvement",
          "PVOD/PCH",
          "PPH",
          "idiopathic pulmonary hypertension"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pulmonary arterial hypertension (PAH) is a group of diseases characterized by mean pulmonary artery pressure >20 mmHg and elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, have overt features of venous/capillary involvement (pulmonary veno-occlusive disease, PVOD/pulmonary capillary hemangiomatosis, PCH), induced by drug or toxin (drug-or toxin-induced PAH), or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease)."
      },
      "child_count": 5,
      "reference_id": "MONDO:0015924"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension"
    }
  ]
}