{
  "id": 17155,
  "label": "pilocytic astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016691",
  "properties": {
    "xrefs": [
      "DOID:4851",
      "GARD:0009808",
      "ICDO:9421/1",
      "MEDGEN:87271",
      "NANDO:2200084",
      "NCIT:C4047",
      "ONCOTREE:PAST",
      "Orphanet:251612",
      "SCTID:763865009",
      "UMLS:C0334583"
    ],
    "synonyms": [
      "astrocytoma, benign",
      "astrocytoma, pilocytic, benign",
      "grade I astrocytic neoplasm",
      "grade I astrocytic tumor",
      "grade I astrocytic tumour",
      "grade I astrocytoma",
      "pilocytic astrocytoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Pilocytic astrocytoma is a rare subtype of low-grade glioma of the central nervous system characterized by a well circumscribed, often cystic, brain tumor with a discrete mural nodule and long, hair-like projections that extend from the neoplastic astrocytes. Depending on the primary localization and the size of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), blurred vision, decreased visual acuity, ataxia and/or nystagmus, among others. It is most commonly located in the cerebellum, but occurrence in the hypothalamus, brain stem, optic chiasma, and hemispheres has also been reported."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 17149,
      "label": "low-grade astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19525,
        20694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020706",
          "MEDGEN:727259",
          "MedDRA:10065869",
          "Orphanet:251592",
          "UMLS:C1314694"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 10,
      "reference_id": "MONDO:0016685"
    }
  ],
  "children": [
    {
      "id": 5132,
      "label": "cerebellar pilocytic astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5131,
        17155,
        20620
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4853",
          "GARD:0023392",
          "MEDGEN:91158",
          "NCIT:C6809",
          "SCTID:277507004",
          "UMLS:C0349620"
        ],
        "synonyms": [
          "cerebellar pilocytic astrocytoma",
          "cerebellum pilocytic astrocytoma",
          "pilocytic astrocytoma of cerebellum",
          "pilocytic astrocytoma of the cerebellum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO Grade 1 astrocytoma which arises in the cerebellum. The tumor is composed of spindle shaped cells with numerous collections of reddish astrocytic fibers called Rosenthal fibers. Over 80% or the cerebellar astrocytomas of childhood are pilocytic. Pilocytic astrocytomas may rarely occur in adults. They are usually treated by surgical resection and in most cases have a favorable prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003168"
    },
    {
      "id": 5852,
      "label": "childhood pilocytic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4578,
        17155
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6812",
          "GARD:0023771",
          "MEDGEN:232355",
          "NANDO:2200084",
          "NCIT:C4048",
          "UMLS:C1332995"
        ],
        "synonyms": [
          "pilocytic astrocytoma",
          "childhood pilocytic astrocytoma",
          "paediatric pilocytic astrocytoma",
          "pediatric pilocytic astrocytoma",
          "pilocytic astrocytoma of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A pilocytic astrocytoma that occurs during childhood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004000"
    },
    {
      "id": 17156,
      "label": "pilomyxoid astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17155
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4845",
          "GARD:0020710",
          "ICDO:9425/3",
          "MEDGEN:276757",
          "NCIT:C40315",
          "ONCOTREE:PMA",
          "Orphanet:251615",
          "UMLS:C1519086"
        ],
        "synonyms": [
          "PMA"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An astrocytic tumor of uncertain relation to pilocytic astrocytoma. It occurs predominantly in infants and young children. It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies. The clinical course is usually aggressive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016692"
    },
    {
      "id": 26053,
      "label": "pilocytic astrocytoma with histological features of anaplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17155
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027184",
          "Orphanet:673585"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0971118"
    }
  ],
  "roots": [
    {
      "id": 17149,
      "label": "low-grade astrocytoma"
    }
  ]
}