{
  "id": 17014,
  "label": "infectious embryofetopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016511",
  "properties": {
    "xrefs": [
      "MEDGEN:1736309",
      "Orphanet:232035",
      "UMLS:C5439342"
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 7200,
      "label": "infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050117",
          "EFO:0005741",
          "ICD10CM:A00-B99",
          "ICD9:079.0",
          "ICD9:136.8",
          "ICD9:136.9",
          "IDO:0000436",
          "MEDGEN:1057",
          "MESH:D003141",
          "NCIT:C26726",
          "SCTID:40733004",
          "UMLS:C0009450"
        ],
        "synonyms": [
          "communicable disease",
          "infection",
          "infectious",
          "infectious disease",
          "infectious diseases and manifestations",
          "infectious disorder",
          "transmissible disease",
          "clinical infection",
          "disease by infectious agent"
        ],
        "definition": "A disorder directly resulting from the presence and activity of a microbial, viral, or parasitic agent in humans. It can be transmitted by direct or indirect contact."
      },
      "child_count": 35,
      "reference_id": "MONDO:0005550"
    },
    {
      "id": 19507,
      "label": "developmental defect during embryogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:759.7",
          "MEDGEN:1825997",
          "NCIT:C99267",
          "Orphanet:93890",
          "SCTID:400038003",
          "UMLS:C5680284"
        ],
        "synonyms": [
          "congenital malformation syndrome",
          "developmental defect during embryogenesis",
          "disorder of embryonic morphogenesis",
          "embryonic morphogenesis disease",
          "malformation syndrome",
          "rare developmental defect during embryogenesis"
        ],
        "definition": "A disease that has its basis in the disruption of embryonic morphogenesis."
      },
      "child_count": 52,
      "reference_id": "MONDO:0019755"
    }
  ],
  "children": [
    {
      "id": 7342,
      "label": "congenital syphilis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7568,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9856",
          "EFO:0007219",
          "GARD:0022036",
          "ICD10CM:A50",
          "ICD10WHO:A50",
          "ICD9:090",
          "ICD9:090.9",
          "MEDGEN:52622",
          "MESH:D013590",
          "NCIT:C84649",
          "NORD:1753",
          "Orphanet:499009",
          "SCTID:35742006",
          "UMLS:C0039131",
          "icd11.foundation:587996426"
        ],
        "synonyms": [
          "MTCT of syphilis",
          "congenital syphilis",
          "mother-to-child transmission of syphilis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005714"
    },
    {
      "id": 7343,
      "label": "congenital toxoplasmosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4427,
        7581,
        17014,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13336",
          "EFO:0007220",
          "GARD:0018708",
          "ICD10CM:P37.1",
          "ICD9:771.2",
          "MEDGEN:52799",
          "MESH:D014125",
          "MedDRA:10010652",
          "NANDO:2200892",
          "NCIT:C50503",
          "Orphanet:858",
          "SCTID:73893000",
          "UMLS:C0040560",
          "icd11.foundation:1194018225"
        ],
        "synonyms": [
          "Toxoplasma embryofetopathy",
          "Toxoplasma embryopathy",
          "congenital toxoplasmosis",
          "mother-to-child transmission of toxoplasmosis",
          "toxoplasmosis, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Toxoplasma infection that is present from birth."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005715"
    },
    {
      "id": 17677,
      "label": "congenital rubella syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6440,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007218",
          "GARD:0004744",
          "ICD10CM:P35.0",
          "ICD9:771.0",
          "MEDGEN:19841",
          "MESH:D012410",
          "MedDRA:10010618",
          "NANDO:2200890",
          "NCIT:C34992",
          "NORD:1681",
          "Orphanet:290",
          "SCTID:1857005",
          "UMLS:C0035921",
          "icd11.foundation:1059053724"
        ],
        "synonyms": [
          "CRS",
          "Rubella, Congenital",
          "congenital rubella",
          "congenital rubella syndrome",
          "fetal rubella syndrome",
          "foetal rubella syndrome",
          "mother-to-child transmission of rubella syndrome",
          "rubella congenital"
        ],
        "definition": "An infectious embryofetopathy that may present in an infant as a result of maternal infection and subsequent fetal infection with rubella virus. CRS can lead to deafness, cataract, and variety of other permanent manifestations including cardiac and neurological defects."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017361"
    },
    {
      "id": 17683,
      "label": "congenital varicella syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        6834,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000045",
          "ICD9:771.2",
          "MEDGEN:87473",
          "NCIT:C116800",
          "NORD:1003",
          "Orphanet:291",
          "SCTID:277644009",
          "UMLS:C0343560",
          "icd11.foundation:2071159826"
        ],
        "synonyms": [
          "antenatal varicella virus infection",
          "mother-to-child transmission of varicella syndrome",
          "Varicella embryopathy",
          "Varicella virus antenatal infection",
          "fetal effects of chickenpox",
          "fetal effects of varicella zoster virus",
          "fetal varicella infection",
          "fetal varicella zoster syndrome",
          "foetal effects of chickenpox",
          "foetal effects of varicella zoster virus",
          "foetal varicella infection",
          "foetal varicella zoster syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Fetal varicella syndrome (CVS) is an acquired developmental anomaly syndrome characterized by skin, neurological, ocular, limbs and growth defects secondary to maternal Varicella-Zoster Virus (VZV) infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017372"
    },
    {
      "id": 17685,
      "label": "congenital enterovirus infection",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7368,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002130",
          "MEDGEN:904399",
          "Orphanet:292",
          "SCTID:716865000",
          "UMLS:C4274223",
          "icd11.foundation:1981771784"
        ],
        "synonyms": [
          "antenatal enterovirus infection",
          "congenital enterovirus infection",
          "congenital enterovirus infectious disease",
          "congenital infection caused by enterovirus",
          "mother-to-child transmission of enterovirus infection"
        ],
        "definition": "Congenital viral infections with enteroviruses (EV) including coxsackie viruses and ECHO viruses is an infectious embryofetopathy that have been reported to cause spontaneous abortion, stillbirth, fetal malformations and acute systemic illness in the newborn."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017375"
    },
    {
      "id": 17745,
      "label": "fetal parvovirus syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17014,
        21676
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004236",
          "MEDGEN:443992",
          "MESH:C536301",
          "Orphanet:295",
          "SCTID:715197005",
          "UMLS:C2931167",
          "icd11.foundation:648536096"
        ],
        "synonyms": [
          "Human parvovirus B19 caused infectious embryofetopathy",
          "Human parvovirus B19 infectious embryofetopathy",
          "Parvovirus antenatal infection",
          "mother-to-child transmission of parvovirus syndrome",
          "Maternofetal infection by parvovirus",
          "Parvovirus B19 antenatal infection",
          "fifth disease"
        ],
        "definition": "Foetal parvovirus syndrome is a foetopathy likely to occur when a pregnant woman is infected by parvovirus B19. In adults, the virus causes a butterfly erythema infectiosum (also called Fifth Disease; 'slapped cheek disease') and flu-like symptoms with symmetric polyarthralgias, which usually do not warrant prenatal diagnosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017453"
    },
    {
      "id": 18983,
      "label": "congenital Epstein-Barr virus infection",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6834,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018903",
          "MEDGEN:908580",
          "Orphanet:70596",
          "SCTID:716660007",
          "UMLS:C4274357",
          "icd11.foundation:1861788994"
        ],
        "synonyms": [
          "antenatal EBV infection",
          "antenatal Epstein-Barr virus infection",
          "congenital EBV infection",
          "mother-to-child transmission of Epstein-Barr virus infection"
        ],
        "definition": "Congenital Epstein-Barr virus (EBV) infection causes no clinical manifestations in the majority of infants. Indeed, the occurrence of congenital infection with EBV has never been demonstrated conclusively and must be very rare. One case have been reported to present after birth, multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), dystrophy, generalized hypotonia, hepatosplenomegaly, diffuse petechiae and hematomas and multiple areas of metaphysitis of the long bones at birth. A low birth weight was also reported. No specific follow-up of the fetus is recommended following maternal EBV primary-infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019094"
    },
    {
      "id": 21150,
      "label": "fetal enterovirus syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        7368,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002302"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023143"
    },
    {
      "id": 21151,
      "label": "fetal parainfluenza virus type 3 syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        17014,
        23100
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002309"
        ],
        "synonyms": [
          "Human respirovirus 3 caused infectious embryofetopathy",
          "Human respirovirus 3 infectious embryofetopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A syndrome caused by HPIV-3."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023147"
    },
    {
      "id": 23097,
      "label": "congenital herpes virus infection",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7411,
        17014
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002669",
          "MEDGEN:908142",
          "SCTID:715337002",
          "UMLS:C4275250"
        ],
        "synonyms": [
          "Herpesviridae caused infectious embryofetopathy",
          "Herpesviridae infectious embryofetopathy",
          "congenital herpes virus infection",
          "congenital infection caused by herpes virus"
        ],
        "definition": "An infectious embryofetopathy caused by infection with Herpesviridae."
      },
      "child_count": 4,
      "reference_id": "MONDO:0042971"
    }
  ],
  "roots": [
    {
      "id": 7200,
      "label": "infectious disease"
    },
    {
      "id": 19507,
      "label": "developmental defect during embryogenesis"
    }
  ]
}