{
  "id": 16832,
  "label": "high-grade neuroendocrine carcinoma of the corpus uteri",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016269",
  "properties": {
    "xrefs": [
      "GARD:0020482",
      "MEDGEN:1664315",
      "Orphanet:213731",
      "UMLS:C4751234"
    ],
    "synonyms": [
      "high-grade neuroendocrine carcinoma of the uterine corpus",
      "poorly differentiated neuroendocrine carcinoma of the corpus uteri",
      "poorly differentiated neuroendocrine carcinoma of the endometrium"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "High-grade neuroendocrine carcinoma of the corpus uteri is an extremely rare, aggressive, primary uterine neoplasm, originating from neuroendocrine cells scattered within the endometrium, characterized, macroscopically, by a bulky, frequently polypoid, mass with abundant necrosis located in the uterus and, histologically, by rosette-like and cord-like structures consisting of small, rounded cells with oval nuclei and scarce cytoplasm. Patients often present with dysfunctional uterine bleeding, pelvic or abdominal mass and, especially in later stages of the disease, abdominal pain. Symptomatic metastatic spread or symptoms related to a paraneoplastic syndrome, such as retinopathy, or Cushing syndrome due to ectopic ACTH production, may be associated."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7594,
      "label": "uterine corpus cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4754,
        20461
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9460",
          "EFO:0007532",
          "ICD9:182",
          "NCIT:C61574",
          "SCTID:371972005"
        ],
        "synonyms": [
          "body of uterus cancer",
          "cancer of body of uterus",
          "cancer of the corpus uteri",
          "corpus uteri cancer",
          "malignant body of uterus neoplasm",
          "malignant neoplasm of body of uterus",
          "uterine (including endometrial) cancer",
          "uterine corpus cancer",
          "endometrial cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the body of uterus."
      },
      "child_count": 24,
      "reference_id": "MONDO:0006003"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:170",
          "ICD9:194.9",
          "MEDGEN:56319",
          "MESH:D004701",
          "NCIT:C3575",
          "UMLS:C0153658"
        ],
        "synonyms": [
          "endocrine neoplasm",
          "Endocrine tumour",
          "cancer of endocrine gland",
          "endocrine cancer",
          "endocrine gland cancer",
          "endocrine neoplasm, malignant",
          "malignant endocrine gland neoplasm",
          "malignant endocrine gland tumor",
          "malignant endocrine gland tumour",
          "malignant endocrine neoplasm",
          "malignant endocrine tumor",
          "malignant endocrine tumour",
          "malignant neoplasm of endocrine gland",
          "malignant neoplasm of the endocrine gland",
          "malignant tumor of endocrine gland",
          "malignant tumor of the endocrine gland",
          "malignant tumour of the endocrine gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0021069"
    },
    {
      "id": 20702,
      "label": "uterine corpus neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314,
        20461
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025347",
          "MEDGEN:925580",
          "NCIT:C126771",
          "UMLS:C4288048"
        ],
        "synonyms": [
          "body of uterus NET",
          "body of uterus neuroendocrine neoplasm",
          "body of uterus neuroendocrine tumor",
          "body of uterus neuroendocrine tumor, well differentiated, low or intermediate grade",
          "body of uterus neuroendocrine tumour",
          "neuroendocrine neoplasm of body of uterus",
          "uterine corpus neuroendocrine neoplasm",
          "uterine corpus neuroendocrine tumor",
          "uterine corpus neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm with neuroendocrine differentiation that arises from the uterine corpus. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021650"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7594,
      "label": "uterine corpus cancer"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm"
    },
    {
      "id": 20702,
      "label": "uterine corpus neuroendocrine neoplasm"
    }
  ]
}