{
  "id": 16708,
  "label": "sporadic Creutzfeldt-Jakob disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016079",
  "properties": {
    "xrefs": [
      "GARD:0006956",
      "ICD9:046.19",
      "MEDGEN:377682",
      "MedDRA:10011384",
      "NANDO:1200187",
      "Orphanet:204",
      "SCTID:713060000",
      "UMLS:C1852467",
      "icd11.foundation:1553463690"
    ],
    "synonyms": [
      "sporadic CJD"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare sporadic human prion disease characterized by rapidly progressive cognitive impairment in combination with variable neurologic signs and symptoms including myoclonus, visual or cerebellar problems, pyramidal or extrapyramidal features, or akinetic mutism. Brain imaging may show high signal intensity in caudate, putamen, and/or cortical regions, and a typical EEG pattern consisting of generalized periodic sharp wave complexes is observed in many cases. The disease is invariably fatal within less than two years. Neuropathologic examination reveals deposition of abnormal prion protein in brain tissue, as well as spongiform change and massive neuronal loss and gliosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7041,
      "label": "Creutzfeldt Jacob disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7097
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11949",
          "EFO:0004226",
          "GARD:0024173",
          "ICD9:046.1",
          "ICD9:046.19",
          "MEDGEN:7179",
          "MESH:D007562",
          "NCIT:C26802",
          "NORD:1014",
          "SCTID:792004",
          "UMLS:C0022336"
        ],
        "synonyms": [
          "CJD",
          "CJD (Creutzfeldt Jakob disease)",
          "Creutzfeldt Jakob Disease",
          "Creutzfeldt-Jacob disease",
          "Jakob-Creutzfeldt disease",
          "classic Creutzfeldt-Jakob disease",
          "Creutzfeldt-Jakob disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare transmittable degenerative disorder of the brain caused by prions. Morphologically it is characterized by spongiform degeneration of the cerebral and cerebellar cortex. Signs and symptoms include sleep disturbances, personality changes, aphasia, ataxia, muscle atrophy and weakness, visual loss, and myoclonus. It usually leads to death within a year from the onset of the disease."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005357"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7041,
      "label": "Creutzfeldt Jacob disease"
    }
  ]
}