{
  "id": 16705,
  "label": "filariasis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016075",
  "properties": {
    "xrefs": [
      "DOID:1080",
      "GARD:0018757",
      "ICD10CM:B74",
      "ICD10WHO:B74",
      "ICD9:125.9",
      "MEDGEN:4706",
      "MESH:D005368",
      "MedDRA:10016674",
      "NCIT:C34611",
      "NORD:1148",
      "Orphanet:2034",
      "SCTID:105706003",
      "UMLS:C0016085",
      "icd11.foundation:1975325075"
    ],
    "definition": "A parasitic disease caused by tissue-invasive, vector-borne nematodes which can be found anywhere in the human body and that are transmitted to humans through the bite of an infected mosquito or fly or by consumption of unsafe drinking water and which, depending on the subtype can manifest with lymphedema, dermatitis, subcutaneous edema and eye involvement. The disorder is a major public health problem in many tropical and subtropical countries. Six subtypes have been described in the literature: lymphatic filariasis, onchocerciasis, loiasis, mansonelliasis, dirofilariasis and dracunculiasis caused by Wuchereria bancrofti and filarioidea of the genus Brugia; Onchocerca volvulus; Loa loa; Mansonella; Dirofilaria; and Dracunculus medinensis, respectively. Tropical eosinophilia is considered a frequent manifestation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6448,
      "label": "helminthiasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6859
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:883",
          "EFO:1001342",
          "ICD10CM:B65-B83",
          "ICD9:120-129",
          "ICD9:128.8",
          "ICD9:128.9",
          "MEDGEN:6765",
          "MESH:D006373",
          "NCIT:C84751",
          "SCTID:27601005",
          "UMLS:C0018889"
        ],
        "synonyms": [
          "helminthiasis",
          "worm infection"
        ],
        "definition": "A parasitic infection characterized by the infestation with worms, mainly in the intestine."
      },
      "child_count": 22,
      "reference_id": "MONDO:0004664"
    }
  ],
  "children": [
    {
      "id": 7381,
      "label": "filarial elephantiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3994,
        7094,
        16705,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12211",
          "EFO:0007272",
          "GARD:0003321",
          "ICD9:374.83",
          "MEDGEN:8583",
          "MESH:D004605",
          "MedDRA:10016675",
          "NCIT:C128360",
          "NORD:1082",
          "Orphanet:2035",
          "SCTID:14100003",
          "SCTID:240820001",
          "UMLS:C0013884",
          "icd11.foundation:247221550"
        ],
        "synonyms": [
          "Elephantiasis",
          "elephantiasis",
          "eyelid elephantiasis",
          "Bancroftian filariasis",
          "Malayi tropical eosinphilia",
          "Wuchereria Bancrofti infection",
          "Wuchereriasis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Parasitic infestation of the human lymphatic system by wuchereria bancrofti or brugia malayi. It is also called lymphatic filariasis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005761"
    },
    {
      "id": 7452,
      "label": "mansonelliasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7539,
        16705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1081",
          "DOID:14422",
          "EFO:0007357",
          "GARD:0008216",
          "ICD10CM:B74.4",
          "ICD9:125.4",
          "MEDGEN:6213",
          "MESH:D004154",
          "MESH:D008368",
          "NCIT:C34540",
          "NCIT:C84882",
          "Orphanet:2459",
          "SCTID:15629006",
          "SCTID:240849009",
          "UMLS:C0024759",
          "icd11.foundation:1504434405"
        ],
        "synonyms": [
          "Acanthocheilonema perstans infection",
          "Acanthocheilonemiasis",
          "Dipetalonema infection",
          "Dipetalonema infections",
          "Mansonella perstans",
          "Mansonella perstans caused disease or disorder",
          "Mansonella perstans infections",
          "Mansonellosis",
          "dipetalonemiasis",
          "infection by Dipetalonema perstans (disorder) [ambiguous]"
        ],
        "definition": "A parasitic infection caused by the nematode Mansonella, including M. ozzardi, M. perstans (Dipetalonema perstans), and M. streptocerca (Dipetalonema streptocerca). Signs and symptoms include pruritus, headache, fever, arthralgias, and eosinophilia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005838"
    },
    {
      "id": 7550,
      "label": "setariasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7539,
        16705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1079",
          "GARD:0024262",
          "MEDGEN:11393",
          "MESH:D012719",
          "SCTID:4414005",
          "UMLS:C0036850"
        ],
        "synonyms": [
          "Setaria <nematode> caused disease or disorder",
          "Setaria <nematode> disease or disorder",
          "Setaria <nematode> infectious disease"
        ],
        "definition": "Infection with nematodes of the genus Setaria. This condition is usually seen in cattle and equines and is of little pathogenic significance, although migration of the worm to the eye may lead to blindness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005957"
    },
    {
      "id": 16422,
      "label": "dirofilariasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7539,
        16705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1082",
          "EFO:0007239",
          "GARD:0011908",
          "ICD9:125.6",
          "MEDGEN:4344",
          "MESH:D004184",
          "Orphanet:166291",
          "SCTID:73328005",
          "UMLS:C0012602",
          "icd11.foundation:1349492056"
        ],
        "synonyms": [
          "Dirofilaria caused disease or disorder",
          "Dirofilaria disease or disorder",
          "infection by Dirofilaria"
        ],
        "definition": "Infection with nematodes of the genus dirofilaria, usually in animals, especially dogs, but occasionally in humans."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015636"
    },
    {
      "id": 16982,
      "label": "dracunculiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7539,
        16705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14418",
          "EFO:0007241",
          "GARD:0006286",
          "ICD10CM:B72",
          "ICD10WHO:B72",
          "ICD9:125.7",
          "MEDGEN:41653",
          "MESH:D004320",
          "MedDRA:10013618",
          "NCIT:C84677",
          "NORD:1060",
          "Orphanet:231",
          "SCTID:396334002",
          "UMLS:C0013100",
          "icd11.foundation:1662537619"
        ],
        "synonyms": [
          "Dracunculosis",
          "Dracunculus medinensis caused disease or disorder",
          "Dracunculus medinensis disease or disorder",
          "Dracunculus medinensis infectious disease",
          "Guinea worm disease",
          "Medina worm disease",
          "dracontiasis",
          "medinensis",
          "GWD",
          "Guinea worm infection",
          "parasitic infection caused by Dracunculus medinensis"
        ],
        "definition": "Dracunculiasis (Guinea worm disease) is a neglected tropical disease (NTD) characterized by a painful burning skin lesion from which the Dracunculus medinensis parasite emerges approximately 1 year after infection resulting from consumption of unsafe drinking water containing parasite-infected copepods (Cyclops spp., microcrustacea also called water fleas)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016472"
    },
    {
      "id": 17060,
      "label": "loiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13523",
          "EFO:1000729",
          "GARD:0003283",
          "ICD10CM:B74.3",
          "ICD9:125.2",
          "MEDGEN:6132",
          "MESH:D008118",
          "MedDRA:10024797",
          "NCIT:C34784",
          "Orphanet:2404",
          "SCTID:44250009",
          "UMLS:C0023968",
          "icd11.foundation:709184369"
        ],
        "synonyms": [
          "African eye worm",
          "Loa loa filariasis"
        ],
        "definition": "Loiasis is a form of filariasis (see this term), caused by the parasitic worm Loa loa, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016566"
    },
    {
      "id": 17497,
      "label": "onchocerciasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7539,
        16705,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11678",
          "EFO:0007402",
          "GARD:0007252",
          "ICD10CM:B73",
          "ICD10WHO:B73",
          "ICD9:125.3",
          "MEDGEN:14477",
          "MESH:D009855",
          "MedDRA:10030314",
          "MedDRA:10039202",
          "NCIT:C34861",
          "Orphanet:2737",
          "SCTID:38539003",
          "UMLS:C0029001",
          "icd11.foundation:106136071"
        ],
        "synonyms": [
          "Onchocerca volvulus infection",
          "infection by Onchocerca volvulus",
          "onchocerciasis",
          "River blindness",
          "Robles' disease",
          "infection caused by Onchocerca volvulus",
          "onchocercosis"
        ],
        "definition": "Onchocerciasis is a form of filariasis, caused by the parasitic worm Onchocerca volvulus, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0017137"
    }
  ],
  "roots": [
    {
      "id": 6448,
      "label": "helminthiasis"
    }
  ]
}