{
  "id": 16159,
  "label": "medullary thyroid gland carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015277",
  "properties": {
    "xrefs": [
      "DOID:3973",
      "GARD:0007004",
      "HP:0002865",
      "MEDGEN:66772",
      "MedDRA:10027101",
      "NANDO:2201054",
      "NCIT:C3879",
      "ONCOTREE:THME",
      "Orphanet:1332",
      "SCTID:255032005",
      "UMLS:C0238462",
      "icd11.foundation:578519098"
    ],
    "synonyms": [
      "C cell carcinoma",
      "MTC",
      "carcinoma of parafollicular cell",
      "carcinoma, C-cell, malignant",
      "medullary carcinoma",
      "medullary carcinoma of the thyroid",
      "medullary carcinoma of the thyroid gland",
      "medullary carcinoma of thyroid",
      "medullary carcinoma of thyroid gland",
      "medullary thyroid cancer",
      "medullary thyroid carcinoma",
      "medullary thyroid gland carcinoma",
      "parafollicular cell carcinoma",
      "thyroid gland medullary cancer",
      "thyroid gland medullary carcinoma",
      "thyroid gland neuroendocrine carcinoma",
      "thyroid medullary carcinoma",
      "THME",
      "medullary thyroid cancer (MTC)",
      "thyroid cancer, medullary",
      "thyroid carcinoma, medullary"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 6768,
      "label": "thyroid gland follicular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16290,
        21537
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3962",
          "EFO:0000501",
          "GARD:0024144",
          "HP:0006731",
          "ICDO:8330/3",
          "ICDO:8331/3",
          "MEDGEN:64630",
          "MESH:D018263",
          "NCIT:C8054",
          "ONCOTREE:THFO",
          "SCTID:255028004",
          "UMLS:C0206682"
        ],
        "synonyms": [
          "follicular cancer of the thyroid",
          "follicular cancer of the thyroid gland",
          "follicular cancer of thyroid",
          "follicular cancer of thyroid gland",
          "thyroid gland follicular cancer",
          "well-differentiated follicular carcinoma",
          "carcinoma of thyroid follicle",
          "carcinoma, follicular cell, malignant",
          "follicular carcinoma",
          "follicular carcinoma of the thyroid",
          "follicular carcinoma of the thyroid gland",
          "follicular carcinoma of thyroid",
          "follicular carcinoma of thyroid gland",
          "follicular thyroid cancer",
          "follicular thyroid carcinoma",
          "follicular thyroid gland carcinoma",
          "thyroid follicle carcinoma",
          "thyroid follicular carcinoma",
          "thyroid gland follicular carcinoma",
          "well-differentiated follicular adenocarcinoma",
          "follicular adenocarcinoma",
          "follicular adenocarcinoma (morphologic abnormality)",
          "follicular adenocarcinoma, well differentiated",
          "follicular adenocarcinoma, well differentiated (morphologic abnormality)",
          "thyroid gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The nuclear features which characterize the thyroid gland papillary carcinoma are absent. Radiation exposure is a risk factor and it comprises approximately 10% to 15% of thyroid cancers. Clinically, it usually presents as a solitary mass in the thyroid gland. It is generally unifocal and thickly encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures include thyroid ultrasound and fine needle biopsy."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005034"
    }
  ],
  "children": [
    {
      "id": 9287,
      "label": "familial medullary thyroid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16159,
        18918
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050547",
          "GARD:0016901",
          "MEDGEN:322311",
          "MESH:C536911",
          "NCIT:C46099",
          "OMIM:155240",
          "Orphanet:99361",
          "UMLS:C1833921"
        ],
        "synonyms": [
          "medullary thyroid carcinoma",
          "familial MTC",
          "familial medullary thyroid carcinoma",
          "hereditary medullary thyroid gland carcinoma",
          "hereditary thyroid medullary carcinoma",
          "thyroid carcinoma, familial medullary",
          "Fmtc",
          "MTC",
          "Mtc1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007958"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 6768,
      "label": "thyroid gland follicular carcinoma"
    }
  ]
}