{
  "id": 16073,
  "label": "primary adrenal insufficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015128",
  "properties": {
    "xrefs": [
      "GARD:0019802",
      "MEDGEN:854614",
      "MedDRA:10052381",
      "NCIT:C113172",
      "Orphanet:101958",
      "UMLS:C3887896"
    ],
    "synonyms": [
      "Addison's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A hormonal disorder that occurs when the adrenal glands fail to release adequate amounts of glucocorticoids (cortisol), mineralocorticoids (aldosterone, 11-deoxycorticosterone), and androgens (dehydroepiandrosterone) to meet physiologic needs, despite release of ACTH from the pituitary."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2700,
      "label": "adrenocortical insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4842
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10493",
          "EFO:0009491",
          "ICD9:255.4",
          "ICD9:255.41",
          "MEDGEN:589758",
          "MESH:D000309",
          "NCIT:C26691",
          "SCTID:386584007",
          "UMLS:C0405580",
          "icd11.foundation:733056203"
        ],
        "synonyms": [
          "adrenal cortical hypofunction",
          "adrenal cortical insufficiency",
          "adrenal gland insufficiency",
          "adrenal insufficiency",
          "adrenocortical insufficiency",
          "hypocortisolemia",
          "hypocortisolism",
          "hypoadrenalism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000004"
    }
  ],
  "children": [
    {
      "id": 16074,
      "label": "chronic primary adrenal insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16073
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13774",
          "GARD:0019803",
          "ICD9:255.41",
          "MEDGEN:1324",
          "MESH:D000224",
          "MedDRA:10001130",
          "NANDO:1200411",
          "NANDO:2200359",
          "NANDO:2200360",
          "NCIT:C26689",
          "OMIM:240200",
          "Orphanet:101959",
          "SCTID:373662000",
          "UMLS:C0001403"
        ],
        "synonyms": [
          "CPAI",
          "chronic adrenocorticoid insufficiency",
          "hypoadrenocorticism, familial",
          "primary adrenal insufficiency, chronic",
          "primary hypoadrenalism",
          "Addison disease, chronic adrenal insufficiency",
          "adrenal aplasia",
          "adrenal gland hypofunction",
          "adrenal hypoplasia",
          "autoimmune Addison disease",
          "autoimmune adrenalitis",
          "autoimmune primary adrenal insufficiency",
          "classic Addison's disease",
          "hypoadrenocorticism familial",
          "primary Addison's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A chronic disorder of the adrenal cortex resulting in the inadequate production of glucocorticoid and mineralocorticoid hormones."
      },
      "child_count": 8,
      "reference_id": "MONDO:0015129"
    },
    {
      "id": 19542,
      "label": "acute adrenal insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16073,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019257",
          "ICD10CM:E27.2",
          "ICD9:255.41",
          "MEDGEN:56227",
          "NCIT:C112840",
          "Orphanet:95409",
          "SCTID:24867002",
          "UMLS:C0151467",
          "icd11.foundation:114442391"
        ],
        "synonyms": [
          "Addisonian crisis",
          "acute adrenal failure",
          "acute adrenocortical insufficiency",
          "adrenal crisis",
          "adrenocortical crisis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary adrenal insufficiency caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019801"
    }
  ],
  "roots": [
    {
      "id": 2700,
      "label": "adrenocortical insufficiency"
    }
  ]
}