{
  "id": 13060,
  "label": "leishmaniasis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011989",
  "properties": {
    "xrefs": [
      "DOID:9065",
      "EFO:0005044",
      "GARD:0006881",
      "ICD10CM:B55",
      "ICD10WHO:B55",
      "ICD9:085",
      "ICD9:085.9",
      "MEDGEN:9714",
      "MESH:D007896",
      "MedDRA:10024198",
      "NCIT:C34767",
      "NORD:1895",
      "Orphanet:507",
      "SCTID:80612004",
      "UMLS:C0023281",
      "icd11.foundation:1082373067"
    ],
    "synonyms": [
      "cutaneous leishmaniasis (subtype)",
      "visceral leishmaniasis (subtype)"
    ],
    "definition": "Infectious disease that is transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4516,
      "label": "protozoa infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6859
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2789",
          "ICD10CM:B50-B64",
          "MESH:D011528",
          "NCIT:C34953"
        ],
        "synonyms": [
          "protozoal infection",
          "Mastigophora infectious disease",
          "sarcomastigophora infectious disease",
          "parasitic protozoa infectious disease"
        ],
        "definition": "An infection that is caused by protozoans."
      },
      "child_count": 15,
      "reference_id": "MONDO:0002428"
    },
    {
      "id": 23869,
      "label": "vector-borne disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:738484",
          "MESH:D000079426",
          "UMLS:C1640363"
        ],
        "synonyms": [
          "vector-borne infection",
          "vector-borne infectious disease"
        ],
        "definition": "An infectious disease where a pathogen is carried and transmitted by another organism that acts as disease vector."
      },
      "child_count": 49,
      "reference_id": "MONDO:0100120"
    }
  ],
  "children": [
    {
      "id": 7109,
      "label": "visceral leishmaniasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        13060
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9146",
          "EFO:0005045",
          "GARD:0024188",
          "ICD10CM:B55.0",
          "ICD9:085.0",
          "MEDGEN:44098",
          "MESH:D007898",
          "NCIT:C34771",
          "OMIMPS:608207",
          "SCTID:186803007",
          "UMLS:C0023290",
          "icd11.foundation:1646564717"
        ],
        "synonyms": [
          "kala-azar",
          "viscus leishmaniasis",
          "kala-azar susceptibility",
          "kala-azar, susceptibility to"
        ],
        "definition": "A severe form of leishmaniasis characterized by irregular bouts of fever, substantial weight loss, swelling of the spleen and liver, and anemia (which may be serious). If left untreated it may lead to death. Two species of Leishmania are known to give rise to the visceral form of the disease. The species commonly found in East Africa and the Indian subcontinent is L. donovani and the species found in Europe, North Africa, and Latin America is L. infantum, also known as L. chagasi."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005445"
    },
    {
      "id": 7110,
      "label": "cutaneous leishmaniasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        13060,
        21525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9111",
          "EFO:0005046",
          "GARD:0024189",
          "ICD10CM:B55.1",
          "ICD9:085.2",
          "MEDGEN:9715",
          "MESH:D016773",
          "NCIT:C34768",
          "NCIT:C34770",
          "SCTID:186807008",
          "UMLS:C0023283",
          "icd11.foundation:124737785"
        ],
        "synonyms": [
          "Asian desert cutaneous leishmaniasis",
          "zone of skin leishmaniasis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Leishmaniasis affecting the skin. It is the most common form of leishmaniasis. It presents with erythematous macules and papules, and nodules which may eventually ulcerate. The lesions appear in the bite site in the exposed skin areas."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005446"
    },
    {
      "id": 7470,
      "label": "mucocutaneous leishmaniasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        13060
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9155",
          "EFO:0007379",
          "GARD:0024244",
          "ICD10CM:B55.2",
          "ICD9:085.5",
          "MEDGEN:233065",
          "MESH:D007897",
          "NCIT:C34769",
          "UMLS:C1328252",
          "icd11.foundation:1942095878"
        ],
        "synonyms": [
          "American cutaneous leishmaniasis",
          "American mucocutaneous leishmaniasis",
          "cutaneous leishmaniasis, American",
          "mucocutaneous leishmaniasis, (American)"
        ],
        "definition": "The most common form of leishmaniasis that is transmitted through the bite of female phlebotomine sand flies or after exposure to leishmania parasites. It is characterized by skin lesions at the site of insect bite which typically develop within weeks or months after exposure. The lesions typically progress from small papules to open sores with raised borders and central ulcers which can be covered with scales or crust."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005859"
    }
  ],
  "roots": [
    {
      "id": 4516,
      "label": "protozoa infectious disease"
    },
    {
      "id": 23869,
      "label": "vector-borne disease"
    }
  ]
}