{
  "id": 9190,
  "label": "keratolytic winter erythema",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007854",
  "properties": {
    "xrefs": [
      "GARD:0008275",
      "ICD9:695.89",
      "MEDGEN:98359",
      "MESH:C536155",
      "NORD:1286",
      "OMIM:148370",
      "Orphanet:50943",
      "SCTID:239064000",
      "UMLS:C0406756",
      "icd11.foundation:1491245207"
    ],
    "synonyms": [
      "Erythrokeratolysis hiemalis",
      "Oudtshoorn disease",
      "keratolytic winter erythema",
      "Erythrokeratolysis hiemalis ichthyosis",
      "KWE",
      "Oudtshoorn skin",
      "Oudtshoorn skin disease",
      "keratolytic WINTER erythema"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Keratolytic winter erythema is a rare epidermal disease, characterized by recurrent centrifugal palmoplantar peeling and erythema presenting seasonal variation (cold weather). Skin lesions may spread to the dorsum of hands and feet and to the interdigital spaces. Lower legs, knees and thighs may also be involved. Episodes may be preceded by itch and hyperhidrosis. Skin biopsy reveals an epidermal spongiosis with clefting in the stratum corneum, followed by regrowth. Keratolytic winter erythema follows an autosomal dominant mode of transmission."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19129,
      "label": "epidermal disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842776",
          "Orphanet:79353",
          "UMLS:C5681492"
        ],
        "synonyms": [
          "epidermal disease",
          "rare epidermal disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disease that involves the epidermis."
      },
      "child_count": 25,
      "reference_id": "MONDO:0019268"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19129,
      "label": "epidermal disease"
    }
  ]
}