{
  "id": 8454,
  "label": "acanthosis nigricans",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0007035",
  "properties": {
    "xrefs": [
      "DOID:3138",
      "EFO:1000660",
      "HP:0000956",
      "ICD10CM:L83",
      "ICD10WHO:L83",
      "MEDGEN:54",
      "MESH:D000052",
      "NCIT:C26687",
      "Orphanet:924",
      "SCTID:402599005",
      "UMLS:C0000889",
      "Wikipedia:Acanthosis_nigricans",
      "icd11.foundation:71488193"
    ],
    "synonyms": [
      "acanthosis nigricans",
      "acanthosis nigricans (disease)",
      "an - acanthosis nigricans"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A melanotic cutaneous lesion that develops in the axilla and other body folds. It may be idiopathic, drug-induced, or it may be associated with the presence of an endocrine disorder or malignancy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4496,
      "label": "dermatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2723",
          "ICD9:692.9",
          "MEDGEN:849741",
          "MESH:D003872",
          "NCIT:C2983",
          "SCTID:43116000",
          "UMLS:C3875321"
        ],
        "synonyms": [
          "inflammation of skin",
          "inflammation of the skin",
          "inflammation of zone of skin",
          "inflammatory skin disease",
          "skin inflammation",
          "zone of skin inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis."
      },
      "child_count": 66,
      "reference_id": "MONDO:0002406"
    }
  ],
  "children": [
    {
      "id": 9970,
      "label": "acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8454,
        19129
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000453",
          "MEDGEN:348051",
          "MESH:C536000",
          "OMIM:200170",
          "Orphanet:90301",
          "UMLS:C1860215"
        ],
        "synonyms": [
          "acanthosis nigricans muscle cramps acral enlargement",
          "acanthosis nigricans with muscle cramps and acral enlargement",
          "familial insulin resistance with acanthosis nigricans, acral hypertrophy and muscle cramps"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "This syndrome is characterized by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008696"
    },
    {
      "id": 23108,
      "label": "familial acanthosis nigricans",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8454,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:419638",
          "MESH:C531598",
          "OMIM:100600",
          "UMLS:C2930792"
        ],
        "synonyms": [
          "hereditary acanthosis nigricans (disease)",
          "acanthosis nigricans"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An instance of acanthosis nigricans (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043003"
    }
  ],
  "roots": [
    {
      "id": 4496,
      "label": "dermatitis"
    }
  ]
}