{
  "id": 8398,
  "label": "skin appendage carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006973",
  "properties": {
    "xrefs": [
      "EFO:1001183",
      "ICDO:8390/3",
      "MEDGEN:60209",
      "MESH:D018280",
      "MedDRA:10040798",
      "NCIT:C3775",
      "ONCOTREE:SKAC",
      "UMLS:C0206697"
    ],
    "synonyms": [
      "adnexal carcinoma",
      "carcinoma of adnexa",
      "carcinoma of cutaneous appendage",
      "carcinoma of skin appendage",
      "carcinoma, adnexal, malignant",
      "cutaneous appendage carcinoma",
      "skin appendage carcinoma",
      "skin adnexal carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4406,
      "label": "epidermal appendage tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        21436
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2433",
          "ICD9:239.2",
          "MEDGEN:87527",
          "NCIT:C4463",
          "SCTID:126489007",
          "UMLS:C0345988"
        ],
        "synonyms": [
          "Epidermal appendage neoplasm",
          "Epidermal appendage tumour",
          "adnexal neoplasm of skin",
          "adnexal neoplasm of the skin",
          "adnexal tumor of skin",
          "adnexal tumor of the skin",
          "adnexal tumour of skin",
          "adnexal tumour of the skin",
          "cutaneous adnexal neoplasm",
          "cutaneous appendage neoplasm",
          "cutaneous appendage neoplasm (disease)",
          "cutaneous appendage tumor",
          "cutaneous appendage tumour",
          "neoplasm of Epidermal appendage",
          "neoplasm of cutaneous appendage",
          "neoplasm of skin appendage",
          "skin appendage neoplasm",
          "skin appendage tumor",
          "tumor of Epidermal appendage",
          "tumor of cutaneous appendage",
          "tumor of skin appendage",
          "tumor of the skin appendage",
          "tumour of Epidermal appendage",
          "tumour of cutaneous appendage",
          "tumour of skin appendage",
          "tumour of the skin appendage"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002297"
    },
    {
      "id": 4707,
      "label": "skin carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4907,
        6734,
        20690
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3451",
          "EFO:0009259",
          "MEDGEN:195945",
          "NCIT:C4914",
          "UMLS:C0699893"
        ],
        "synonyms": [
          "carcinoma of skin",
          "carcinoma of the skin",
          "carcinoma of zone of skin",
          "non-melanoma cancer of skin",
          "non-melanoma cancer of the skin",
          "non-melanoma skin cancer",
          "nonmelanoma skin cancer",
          "skin cancer, non-melanoma",
          "skin carcinoma",
          "zone of skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the zone of skin"
      },
      "child_count": 39,
      "reference_id": "MONDO:0002656"
    }
  ],
  "children": [
    {
      "id": 5345,
      "label": "skin pilomatrix carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5376",
          "GARD:0022042",
          "ICDO:8110/3",
          "MEDGEN:108439",
          "NCIT:C4114",
          "Orphanet:499182",
          "SCTID:307610008",
          "UMLS:C0585475"
        ],
        "synonyms": [
          "Pilomatrical carcinoma",
          "Trichomatrical carcinoma",
          "calcified epithelial carcinoma of Malherbe",
          "calcifying epitheliocarcinoma",
          "invasive pilomatrixoma",
          "malignant pilomatricoma",
          "matrical carcinoma",
          "pilomatrix carcinoma",
          "pilomatrix carcinoma of skin",
          "pilomatrix carcinoma of the skin",
          "pilomatrix skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003414"
    },
    {
      "id": 7178,
      "label": "sweat gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4329,
        6712,
        8398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5667",
          "EFO:0005591",
          "ICDO:8400/3",
          "MEDGEN:234685",
          "NCIT:C6938",
          "ONCOTREE:AECA",
          "UMLS:C1412016"
        ],
        "synonyms": [
          "carcinoma of sweat gland",
          "carcinoma of the sweat gland",
          "carcinoma, sweat gland, malignant",
          "sweat gland carcinoma",
          "sweat gland carcinoma/apocrine eccrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005524"
    },
    {
      "id": 8388,
      "label": "sebaceous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        8398,
        22966
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4839",
          "DOID:4840",
          "EFO:1001171",
          "ICDO:8410/3",
          "MEDGEN:64632",
          "MESH:D018266",
          "NCIT:C40310",
          "ONCOTREE:SEBA",
          "SCTID:307599002",
          "UMLS:C0206684"
        ],
        "synonyms": [
          "adenocarcinoma, sebaceous, malignant",
          "carcinoma of sebaceous gland",
          "carcinoma of the sebaceous gland",
          "sebaceous cancer",
          "sebaceous carcinoma",
          "sebaceous gland adenocarcinoma",
          "sebaceous gland carcinoma",
          "malignant sebaceous tumor",
          "malignant sebaceous tumour",
          "Seba"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal. It grows in the ocular adnexae and in the skin of head and neck, trunk, genitals, and extremities. It is characterized by the presence of malignant cells with multivesicular and clear cytoplasm. It may recur and metastasize."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006962"
    }
  ],
  "roots": [
    {
      "id": 4406,
      "label": "epidermal appendage tumor"
    },
    {
      "id": 4707,
      "label": "skin carcinoma"
    }
  ]
}