{
  "id": 8077,
  "label": "porokeratosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006602",
  "properties": {
    "xrefs": [
      "DOID:3805",
      "EFO:1000757",
      "GARD:0018989",
      "HP:0200044",
      "ICD9:757.39",
      "MEDGEN:56518",
      "MESH:D017499",
      "MedDRA:10036175",
      "NCIT:C85019",
      "OMIMPS:175800",
      "Orphanet:79358",
      "SCTID:400080004",
      "UMLS:C0162839",
      "Wikipedia:Porokeratosis",
      "icd11.foundation:29524620"
    ],
    "synonyms": [
      "porokeratosis",
      "porokeratosis (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A clonal proliferation of abnormal keratinocytes characterized by the development of localized or multiple atrophic skin patches surrounded by an annular keratotic ring called cornoid lamella."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 8047,
      "label": "keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        23507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:161",
          "EFO:1000720",
          "MEDGEN:9625",
          "MESH:D007642",
          "NCIT:C34745",
          "SCTID:254666005",
          "UMLS:C0022593"
        ],
        "synonyms": [
          "keratoderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disorder consisting of hypertrophy of the stratum corneum of the skin."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006566"
    },
    {
      "id": 19129,
      "label": "epidermal disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842776",
          "Orphanet:79353",
          "UMLS:C5681492"
        ],
        "synonyms": [
          "epidermal disease",
          "rare epidermal disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disease that involves the epidermis."
      },
      "child_count": 25,
      "reference_id": "MONDO:0019268"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MESH:D012873",
          "SCTID:239001006"
        ],
        "synonyms": [
          "disease, genetic skin",
          "diseases, genetic skin",
          "genetic skin disease",
          "genetic skin diseases",
          "genodermatosis",
          "skin disease, genetic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An instance of skin disease that is caused by a modification of the individual's genome."
      },
      "child_count": 228,
      "reference_id": "MONDO:0100118"
    }
  ],
  "children": [
    {
      "id": 9597,
      "label": "porokeratosis plantaris palmaris et disseminata",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016542",
          "MEDGEN:56517",
          "OMIM:175850",
          "Orphanet:737",
          "SCTID:718218005",
          "UMLS:C0162838"
        ],
        "synonyms": [
          "palmar, plantar and disseminated porokeratosis",
          "porokeratosis 2, palmar, plantar, and disseminated",
          "porokeratosis plantaris palmaris et disseminata",
          "POROK2",
          "porokeratosis 2, palmar, plantar, and disseminated type",
          "porokeratosis palmaris Et plantaris disseminata",
          "porokeratosis, palmar, plantar, and disseminated",
          "porokeratosis, palmar, plantar, and disseminated, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Porokeratosis plantaris palmaris et disseminata (PPPD) is a rare form of porokeratosis occurring mainly in adolescence and characterized by small pruritic or painful keratotic papules that first appear on the palms and soles, and may gradually become generalized."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008291"
    },
    {
      "id": 19019,
      "label": "porokeratosis of Mibelli",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004438",
          "ICD9:757.39",
          "MEDGEN:181842",
          "Orphanet:735",
          "SCTID:80432009",
          "UMLS:C0949506"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Porokeratosis of Mibelli (PM) is a form of porokeratosis that is characterized by the presence of brown single or multiple annular plaques of varying size, that are sometimes confluent, with a distinctive sharply-defined keratotic border."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019141"
    },
    {
      "id": 19081,
      "label": "disseminated superficial actinic porokeratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010983",
          "ICD10CM:L56.5",
          "ICD9:692.75",
          "MEDGEN:120561",
          "Orphanet:79152",
          "SCTID:41495000",
          "UMLS:C0265970",
          "icd11.foundation:1828294192"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis characterized by the presence of several small annular plaques with a distinctive keratotic rim found most commonly on sun-exposed areas of the skin, particularly the extremities."
      },
      "child_count": 7,
      "reference_id": "MONDO:0019212"
    },
    {
      "id": 21195,
      "label": "linear porokeratosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009515",
          "MEDGEN:81293",
          "SCTID:238631008",
          "UMLS:C0302319",
          "icd11.foundation:1622319802"
        ],
        "synonyms": [
          "Congenital facial linear porokeratosis (type)",
          "Linear Porokeratosis",
          "Linear porokeratosis",
          "Porokeratosis, Linear",
          "Zosteriform porokeratosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Linear porokeratosis is a rare skin condition characterized by streaks of reddish-brown patches surrounded by a ridge-like border.The patches usually develop in infants or young children, but they sometimes develop in adults."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023246"
    }
  ],
  "roots": [
    {
      "id": 8047,
      "label": "keratosis"
    },
    {
      "id": 19129,
      "label": "epidermal disease"
    },
    {
      "id": 23867,
      "label": "hereditary skin disorder"
    }
  ]
}