{
  "id": 8016,
  "label": "cholesteatoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006530",
  "properties": {
    "xrefs": [
      "DOID:869",
      "EFO:1000675",
      "HP:0009797",
      "ICD9:385.30",
      "MEDGEN:3043",
      "MESH:D002781",
      "NCIT:C2944",
      "SCTID:363668000",
      "UMLS:C0008373"
    ],
    "synonyms": [
      "cholesteatoma",
      "cholesteatoma (disease)",
      "congenital cholesteatoma (type)",
      "primary acquired cholesteatoma (type)",
      "secondary acquired cholesteatoma (type)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A pathologic process characterized by the proliferation of keratinizing squamous epithelium resulting in the accumulation of keratin and cells in the middle ear and/or mastoid. It may be congenital or acquired. If left untreated, it may increase in size and destroy adjacent structures."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 8047,
      "label": "keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        23507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:161",
          "EFO:1000720",
          "MEDGEN:9625",
          "MESH:D007642",
          "NCIT:C34745",
          "SCTID:254666005",
          "UMLS:C0022593"
        ],
        "synonyms": [
          "keratoderma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin disorder consisting of hypertrophy of the stratum corneum of the skin."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006566"
    }
  ],
  "children": [
    {
      "id": 8018,
      "label": "cholesteatoma of external ear",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4807,
        8016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9462",
          "EFO:1000677",
          "ICD10CM:H60.4",
          "ICD9:380.21",
          "MEDGEN:509952",
          "SCTID:35247001",
          "UMLS:C0155398"
        ],
        "synonyms": [
          "cholesteatoma (disease) of external ear",
          "external ear cholesteatoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A cholesteatoma (disease) that involves the external ear."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006532"
    },
    {
      "id": 8019,
      "label": "cholesteatoma of middle ear",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5217,
        8016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10964",
          "EFO:1000678",
          "ICD10CM:H71",
          "ICD10WHO:H71",
          "ICD9:385.3",
          "ICD9:385.32",
          "ICD9:385.33",
          "MEDGEN:57836",
          "MESH:D018424",
          "NCIT:C3654",
          "SCTID:194339007",
          "UMLS:C0155490",
          "icd11.foundation:2134365487"
        ],
        "synonyms": [
          "Epidermosis of ear",
          "Epidermosis of middle ear",
          "cholesteatoma (disease) of middle ear",
          "cholesteatoma of middle ear",
          "cholesteatoma of middle ear and mastoid",
          "cholesteatoma of the middle ear",
          "middle ear cholesteatoma",
          "middle ear cholesteatoma (disease)",
          "unspecified cholesteatoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006533"
    },
    {
      "id": 8056,
      "label": "maxillary sinus cholesteatoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3922,
        8016,
        8301,
        21213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:867",
          "MEDGEN:277346",
          "NCIT:C35868",
          "UMLS:C1334644"
        ],
        "synonyms": [
          "cholesteatoma (disease) of maxillary sinus",
          "maxillary sinus cholesteatoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare, progressive, non-neoplastic pathologic process that arises from the maxillary sinus mucosal epithelium. It is characterized by the proliferation of keratinizing squamous epithelium and the formation of keratin sheets. It may lead to bone erosion and infections. Surgical removal is the appropriate treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006577"
    }
  ],
  "roots": [
    {
      "id": 8047,
      "label": "keratosis"
    }
  ]
}