{
  "id": 7904,
  "label": "primary cutaneous diffuse large B-cell lymphoma, Leg type",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006383",
  "properties": {
    "xrefs": [
      "EFO:1000490",
      "GARD:0020160",
      "ICDO:9680/3",
      "MEDGEN:311155",
      "NCIT:C45194",
      "Orphanet:178544",
      "UMLS:C1709656",
      "icd11.foundation:1418101362"
    ],
    "synonyms": [
      "PCDLBCL,LT",
      "primary cutaneous diffuse large B-cell lymphoma, Leg type"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An aggressive primary cutaneous B-cell lymphoma, usually involving the lower leg. It is composed of a generally monotonous proliferation of immunoblasts, or less frequently centroblasts, with few admixed reactive cells. This type of lymphoma occurs most often in elderly women who present with rapidly growing tumors, usually on one or both legs. Dissemination to extracutaneous sites is frequent. Treatment with combination chemotherapy is usually required."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6694,
        17875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050745",
          "EFO:0000403",
          "GARD:0003178",
          "ICD10CM:C83.3",
          "ICD9:200.7",
          "ICDO:9680/3",
          "MEDGEN:86954",
          "MESH:D016403",
          "MedDRA:10012818",
          "NCIT:C8851",
          "Orphanet:544",
          "UMLS:C0079744",
          "icd11.foundation:1946973604"
        ],
        "synonyms": [
          "DLBCL",
          "diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common."
      },
      "child_count": 60,
      "reference_id": "MONDO:0018905"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18833,
      "label": "diffuse large B-cell lymphoma"
    }
  ]
}