{
  "id": 7787,
  "label": "grade III prostatic intraepithelial neoplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006234",
  "properties": {
    "xrefs": [
      "DOID:8634",
      "EFO:1000283",
      "ICD10CM:D07.5",
      "ICD9:233.4",
      "MEDGEN:1684800",
      "NCIT:C3642",
      "SCTID:92691004",
      "UMLS:C5200982"
    ],
    "synonyms": [
      "PIN III",
      "adenocarcinoma in situ of prostate",
      "adenocarcinoma in situ of the prostate",
      "carcinoma in situ of prostate",
      "carcinoma in situ of prostate gland",
      "grade 3 pin",
      "grade 3 prostatic intraepithelial neoplasia",
      "grade III pin",
      "pin III",
      "prostate adenocarcinoma in situ",
      "prostate carcinoma in situ",
      "prostate gland carcinoma in situ",
      "prostate gland in situ carcinoma",
      "stage 0 prostate gland carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "High grade prostatic intraepithelial neoplasia characterized by the presence of severe architectural and cytologic abnormalities."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6433,
      "label": "in situ carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20078,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8719",
          "ICD9:230-234",
          "ICD9:234.8",
          "ICD9:234.9",
          "ICDO:8010/2",
          "MEDGEN:763",
          "MESH:D002278",
          "NCIT:C2917",
          "SCTID:109355002",
          "UMLS:C0007099"
        ],
        "synonyms": [
          "CIS",
          "carcinoma in situ",
          "carcinoma, in situ, malignant",
          "epithelial tumor, in situ, malignant",
          "intraepithelial carcinoma",
          "non-invasive carcinoma",
          "stage 0 disease"
        ],
        "definition": "A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 63,
      "reference_id": "MONDO:0004647"
    },
    {
      "id": 6882,
      "label": "prostate carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        9621
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10286",
          "EFO:0001663",
          "MEDGEN:108657",
          "NCIT:C4863",
          "UMLS:C0600139"
        ],
        "synonyms": [
          "carcinoma of prostate",
          "carcinoma of prostate gland",
          "carcinoma of the prostate",
          "prostate carcinoma",
          "prostate gland carcinoma",
          "cancer of prostate",
          "cancer of the prostate",
          "prostate cancer",
          "prostate cancer, NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the prostate gland."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005159"
    },
    {
      "id": 6913,
      "label": "prostate intraepithelial neoplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20463,
        21429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002621",
          "ICD10CM:N42.31",
          "MEDGEN:76480",
          "MESH:D019048",
          "NCIT:C4064",
          "SCTID:254901000",
          "UMLS:C0282612"
        ],
        "synonyms": [
          "PIN",
          "pin",
          "pin - prostatic intraepithelial neoplasia",
          "prostate intraepithelial neopl.",
          "prostate intraepithelial neoplasia (pin)",
          "prostatic intraepithelial neoplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland. The neoplastic epithelial cells are confined within the acini and the ducts and they do not invade the surrounding prostatic stroma. Morphologically, it is classified as low or high grade."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005193"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6433,
      "label": "in situ carcinoma"
    },
    {
      "id": 6882,
      "label": "prostate carcinoma"
    },
    {
      "id": 6913,
      "label": "prostate intraepithelial neoplasia"
    }
  ]
}