{
  "id": 7734,
  "label": "cribriform carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006176",
  "properties": {
    "xrefs": [
      "EFO:1000210",
      "ICDO:8201/3",
      "MEDGEN:104694",
      "NCIT:C3680",
      "UMLS:C0205643"
    ],
    "synonyms": [
      "cribriform carcinoma"
    ],
    "definition": "A carcinoma characterized by the presence of a cribriform architectural pattern. Representative examples include the intraductal cribriform breast carcinoma and invasive cribriform breast carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 23477,
      "label": "salivary duct carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2972,
        7734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027981",
          "MEDGEN:220969",
          "NCIT:C5904",
          "ONCOTREE:SDCA",
          "UMLS:C1301194"
        ],
        "synonyms": [
          "carcinoma of duct of salivary gland",
          "carcinoma of salivary duct",
          "carcinoma of the salivary duct",
          "duct of salivary gland carcinoma",
          "high grade salivary duct carcinoma",
          "salivary duct carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044915"
    },
    {
      "id": 23545,
      "label": "cribriform carcinoma of breast",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730,
        7734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5675",
          "MEDGEN:1843502",
          "UMLS:C2138440",
          "icd11.foundation:1025219649"
        ],
        "synonyms": [
          "cribriform carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0045059"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}