{
  "id": 7641,
  "label": "Wilms tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006058",
  "properties": {
    "xrefs": [
      "GARD:0027737",
      "MEDGEN:10221",
      "MESH:D009396",
      "NCIT:C3267",
      "UMLS:C0027708"
    ],
    "synonyms": [
      "Wilms tumor",
      "Wilms' tumor",
      "Wilms' tumour",
      "Wilms tumor (nephroblastoma)",
      "Wilms tumour (nephroblastoma)"
    ],
    "definition": "An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7212,
      "label": "embryonal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:688",
          "EFO:0005784",
          "MEDGEN:45034",
          "NCIT:C3264",
          "ONCOTREE:EMBT",
          "UMLS:C0027654"
        ],
        "synonyms": [
          "embryonal neoplasm",
          "embryonal tumor",
          "embryonal tumour",
          "EMBT",
          "embryonal cancer"
        ],
        "definition": "A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003"
      },
      "child_count": 12,
      "reference_id": "MONDO:0005564"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:154",
          "EFO:1000356",
          "ICDO:8940/3",
          "MEDGEN:64618",
          "MESH:D018198",
          "NCIT:C3729",
          "UMLS:C0206625"
        ],
        "synonyms": [
          "mixed cell type cancer",
          "mixed neoplasm",
          "mixed tumor",
          "mixed tumour",
          "malignant mixed neoplasm",
          "malignant mixed tumor",
          "malignant mixed tumour",
          "mixed neoplasm, malignant",
          "mixed tumor, malignant (morphologic abnormality)",
          "mixed tumor, malignant, NOS (morphologic abnormality)",
          "tumor, mixed, malignant",
          "malignant mixed tumors",
          "malignant mixed tumours",
          "mixed tumors, malignant",
          "tumor, malignant mixed",
          "tumors, malignant mixed"
        ],
        "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005853"
    }
  ],
  "children": [
    {
      "id": 4348,
      "label": "ovarian Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7641,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2153",
          "GARD:0023094",
          "MEDGEN:275296",
          "NCIT:C40443",
          "UMLS:C1518746"
        ],
        "synonyms": [
          "ovarian Wilms tumor",
          "ovarian Wilms' tumor",
          "ovarian Wilms' tumour",
          "ovary Wilms tumor",
          "ovary Wilms tumour",
          "ovarian Wilms' cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An embryonal neoplasm arising from the ovary with morphologic features resembling Wilms tumor of the kidney. It occurs during the reproductive age and may present as a rapidly growing adnexal mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002230"
    },
    {
      "id": 5261,
      "label": "hereditary Wilms tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7641
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5183",
          "GARD:0023447",
          "MEDGEN:146190",
          "NCIT:C8496",
          "OMIMPS:194070",
          "UMLS:C0677779"
        ],
        "synonyms": [
          "familial Wilms tumor",
          "familial Wilms tumour",
          "familial Wilms' tumor",
          "familial Wilms' tumour",
          "hereditary Wilms tumor",
          "hereditary kidney adenosarcoma",
          "hereditary nephroblastoma",
          "hereditary renal adenosarcoma",
          "WT1"
        ],
        "definition": "Familial embryonal neoplasm derived from nephrogenic blastemal cells. Several lines of differentiation, including blastemal, stromal and epithelial, are usually expressed. Comprises approximately 1% of Wilms tumors. (AFIP fascicle version 2.0)"
      },
      "child_count": 14,
      "reference_id": "MONDO:0003321"
    },
    {
      "id": 7707,
      "label": "cervical Wilms tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4978,
        7641
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5190",
          "GARD:0027743",
          "MEDGEN:273129",
          "NCIT:C40236",
          "UMLS:C1516437"
        ],
        "synonyms": [
          "cervical Wilms tumor",
          "cervical Wilms' tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An embryonal neoplasm arising from the cervix with morphologic features resembling Wilms tumor of the kidney."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006144"
    },
    {
      "id": 18919,
      "label": "kidney Wilms tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        7641
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2154",
          "DOID:5176",
          "GARD:0007892",
          "ICDO:8960/3",
          "MedDRA:10029145",
          "NANDO:2200043",
          "NCIT:C40407",
          "NORD:1855",
          "ONCOTREE:WT",
          "Orphanet:654",
          "SCTID:302849000"
        ],
        "synonyms": [
          "Wilms tumor",
          "Wilms tumour",
          "Wilms' tumor",
          "Wilms' tumour",
          "Wilms tumor of the kidney",
          "Wilms tumour of the kidney",
          "Wilms' Tumor",
          "Wilms' tumor of the kidney",
          "Wilms' tumour of the kidney",
          "kidney Wilms tumor",
          "nephroblastoma",
          "nephroblastoma, malignant",
          "renal Wilms tumor",
          "renal Wilms tumour",
          "renal Wilms' tumor",
          "renal embryonic tumor",
          "renal embryonic tumour",
          "adult nephroblastoma",
          "adult renal Wilms' tumour",
          "childhood renal Wilms tumor",
          "childhood renal Wilms tumour",
          "childhood renal Wilms' cancer",
          "embryonal nephroma",
          "nonanaplastic renal Wilm's tumor",
          "nonanaplastic renal Wilm's tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver."
      },
      "child_count": 16,
      "reference_id": "MONDO:0019004"
    }
  ],
  "roots": [
    {
      "id": 7212,
      "label": "embryonal neoplasm"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm"
    }
  ]
}