{
  "id": 7639,
  "label": "sex cord-stromal tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0006055",
  "properties": {
    "xrefs": [
      "DOID:192",
      "EFO:1000052",
      "ICDO:8590/1",
      "MEDGEN:104926",
      "NANDO:2200072",
      "NCIT:C3794",
      "UMLS:C0206724"
    ],
    "synonyms": [
      "Sex cord stromal tumor",
      "Sex cord-stromal neoplasm",
      "Sex cord-stromal tumor",
      "Sex cord-stromal tumor, no ICD-O subtype",
      "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
      "Sex cord-stromal tumour",
      "neoplasm of sex cord",
      "sex cord neoplasm",
      "sex cord tumor",
      "sex cord tumour",
      "sex cord-stromal tumor",
      "specialised gonadal neoplasm",
      "specialised gonadal neoplasm (morphologic abnormality)",
      "specialised gonadal neoplasm NOS (morphologic abnormality)",
      "specialised gonadal tumour",
      "specialised gonadal tumour (qualifier value)",
      "specialized gonadal neoplasm (morphologic abnormality)",
      "specialized gonadal neoplasm NOS (morphologic abnormality)",
      "specialized gonadal tumor (qualifier value)",
      "tumor of sex cord",
      "tumour of sex cord",
      "malignant testicular sex cord-stromal tumor",
      "malignant testicular sex cord-stromal tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A neoplasm involving a sex cord."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 7638,
      "label": "reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000051",
          "MEDGEN:64246",
          "NCIT:C3674",
          "UMLS:C0178830"
        ],
        "synonyms": [
          "neoplasm of reproductive system",
          "neoplasm of the reproductive system",
          "reproductive neoplasm",
          "reproductive system neoplasm",
          "reproductive system neoplasm (disease)",
          "reproductive system tumor",
          "reproductive system tumour",
          "reproductive tumor",
          "reproductive tumour",
          "tumor of reproductive system",
          "tumor of the reproductive system",
          "tumour of reproductive system",
          "tumour of the reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006054"
    }
  ],
  "children": [
    {
      "id": 4740,
      "label": "Sertoli cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3577",
          "ICDO:8630/1",
          "ICDO:8640/1",
          "MEDGEN:11387",
          "MESH:D012707",
          "NCIT:C39976",
          "UMLS:C0036769"
        ],
        "synonyms": [
          "Sertoli cell tumor",
          "tubular androblastoma NOS (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor of the testis or the ovary. It is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002696"
    },
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4757",
          "GARD:0021551",
          "MEDGEN:825921",
          "NCIT:C6358",
          "Orphanet:363489",
          "SCTID:702406000",
          "UMLS:C3840076"
        ],
        "synonyms": [
          "sex cord-stromal tumor of testis",
          "sex cord-stromal tumour of testis",
          "testicular sex cord-stromal neoplasm",
          "testicular sex cord-stromal tumor",
          "testicular sex cord-stromal tumour",
          "testis sex cord-stromal tumor",
          "testis sex cord-stromal tumour",
          "sex cord-stromal neoplasm",
          "sex cord-stromal neoplasm of testis",
          "sex cord-stromal neoplasm of the testis",
          "sex cord-stromal tumor of the testis",
          "sex cord-stromal tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003125"
    },
    {
      "id": 7622,
      "label": "granulosa cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2999",
          "EFO:1000032",
          "MEDGEN:6676",
          "MESH:D006106",
          "NCIT:C3070",
          "ONCOTREE:GRCT",
          "UMLS:C0018206"
        ],
        "synonyms": [
          "granulosa cell neoplasm",
          "granulosa cell neoplasm (disease)",
          "granulosa cell tumor",
          "granulosa cell tumor, adult type (morphologic abnormality)",
          "granulosa cell tumor, sarcomatoid",
          "neoplasm of granulosa cell",
          "tumor of granulosa cell",
          "tumour of granulosa cell",
          "GRCT",
          "granulosa cell tumor, undetermined"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006036"
    },
    {
      "id": 7810,
      "label": "Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2696",
          "EFO:1000321",
          "ICDO:8650/1",
          "MEDGEN:9747",
          "MESH:D007984",
          "NCIT:C3188",
          "UMLS:C0023601"
        ],
        "synonyms": [
          "Leydig cell neoplasm",
          "Leydig cell tumor",
          "interstitial cell neoplasm",
          "interstitial cell tumor",
          "interstitial cell tumour",
          "Leydig cell tumor, undetermined"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006266"
    },
    {
      "id": 11906,
      "label": "gonadoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        4375,
        4558,
        7213,
        7464,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3301",
          "ICDO:9073/1",
          "MEDGEN:104912",
          "MESH:D018238",
          "NCIT:C3754",
          "ONCOTREE:OGBL",
          "UMLS:C0206661"
        ],
        "synonyms": [
          "gonad blastoma",
          "gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype."
      },
      "child_count": 12,
      "reference_id": "MONDO:0010768"
    },
    {
      "id": 20709,
      "label": "ovarian sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080369",
          "GARD:0012285",
          "MEDGEN:154644",
          "NCIT:C4862",
          "ONCOTREE:SCST",
          "UMLS:C0600113"
        ],
        "synonyms": [
          "Sex cord-stromal neoplasm of ovary",
          "Sex cord-stromal neoplasm of the ovary",
          "Sex cord-stromal tumor of ovary",
          "Sex cord-stromal tumor of the ovary",
          "Sex cord-stromal tumour of ovary",
          "Sex cord-stromal tumour of the ovary",
          "ovarian Sex cord-stromal neoplasm",
          "ovarian Sex cord-stromal tumor",
          "ovarian Sex cord-stromal tumour",
          "ovary sex cord-stromal tumor",
          "ovary sex cord-stromal tumour",
          "sex cord-stromal tumor of ovary",
          "sex cord-stromal tumour of ovary",
          "ovarian sex cord tumor with annular tubules",
          "ovarian sex cord tumour with annular tubules",
          "sex cord stromal tumor",
          "sex cord stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021657"
    },
    {
      "id": 21634,
      "label": "sex cord-stromal benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2882,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080368"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A reproductive organ benign neoplasm that arises in the ovary or testis and that is composed of granulosa cells, Leydig cells, Sertoli cells, and/or fibroblasts."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024988"
    },
    {
      "id": 22960,
      "label": "thecoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8600/0",
          "MEDGEN:21505",
          "MESH:D013798",
          "NCIT:C3405",
          "UMLS:C0039747"
        ],
        "synonyms": [
          "thecoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An ovarian or testicular stromal tumor characterized by the presence of lipid-rich neoplastic spindle cells. In females, uterine bleeding is the most common symptom. A minority of post-menopausal women with thecoma have an associated endometrial adenocarcinoma or rarely a malignant mixed mullerian tumor or endometrial stromal sarcoma. Rare cases with nuclear atypia and mitotic activity may metastasize. In males, thecomas are rare and they usually present as slow growing, sometimes painful masses. Metastases have not been reported."
      },
      "child_count": 2,
      "reference_id": "MONDO:0037252"
    },
    {
      "id": 24434,
      "label": "fibrothecoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1668953",
          "UMLS:C4721918"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor characterized by mixed features of both fibroma and thecoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0700036"
    }
  ],
  "roots": [
    {
      "id": 7638,
      "label": "reproductive system neoplasm"
    }
  ]
}