{
  "id": 7250,
  "label": "herpes zoster",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005609",
  "properties": {
    "xrefs": [
      "DOID:8536",
      "EFO:0006510",
      "ICD10CM:B02",
      "ICD9:053",
      "MEDGEN:42437",
      "MESH:D006562",
      "NCIT:C71079",
      "SCTID:4740000",
      "UMLS:C0019360"
    ],
    "synonyms": [
      "Zoster",
      "herpes Zoster",
      "shingles",
      "postherpetic neuralgia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient's initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7249,
      "label": "varicella zoster infection",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006509",
          "ICD9:052.7",
          "MEDGEN:668886",
          "NCIT:C96407",
          "SCTID:309465005",
          "UMLS:C0586989"
        ],
        "synonyms": [
          "Varicella-zoster Virus infection",
          "varicella zoster infection"
        ],
        "definition": "A highly contagious viral infection caused by the varicella zoster virus. Clinically, it may be manifested as shingles or chicken pox."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005608"
    },
    {
      "id": 8092,
      "label": "vesiculobullous skin disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2731",
          "EFO:1000774",
          "MEDGEN:20778",
          "MESH:D012872",
          "UMLS:C0037275"
        ],
        "synonyms": [
          "vesiculobullous skin disease",
          "Sneddon Wilkinson disease",
          "Sneddon-Wilkinson disease",
          "skin diseases, vesicular",
          "subcorneal pustular dermatoses",
          "subcorneal pustular dermatosis",
          "bullous dermatoses",
          "bullous skin disease",
          "bullous skin diseases",
          "dermatoses, bullous",
          "dermatoses, subcorneal pustular",
          "dermatoses, vesiculobullous",
          "dermatosis, subcorneal pustular",
          "pustular dermatoses, subcorneal",
          "pustular dermatosis, subcorneal",
          "skin disease, bullous",
          "skin disease, vesicular",
          "skin disease, vesiculobullous",
          "skin diseases, bullous",
          "vesicular skin disease",
          "vesicular skin diseases",
          "vesiculobullous dermatoses",
          "vesiculobullous skin diseases"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)"
      },
      "child_count": 8,
      "reference_id": "MONDO:0006617"
    },
    {
      "id": 20721,
      "label": "post-viral disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:139.8",
          "MEDGEN:688821",
          "SCTID:123948009",
          "UMLS:C1264605"
        ],
        "synonyms": [
          "sequela of viral disease"
        ],
        "definition": "A post-infectious disorder that follows viral infection but is distinct from the viral infection itself and its usual manifestations."
      },
      "child_count": 13,
      "reference_id": "MONDO:0021674"
    },
    {
      "id": 21328,
      "label": "skin disorder caused by infection",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MESH:D012874"
        ],
        "synonyms": [
          "disease, infectious skin",
          "diseases, infectious skin",
          "infectious skin disease",
          "infectious skin diseases",
          "skin disease, infectious"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Skin diseases caused by bacteria, fungi, parasites, or viruses."
      },
      "child_count": 30,
      "reference_id": "MONDO:0024294"
    },
    {
      "id": 24063,
      "label": "disease arising from reactivation of latent virus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6834
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "latent infection"
        ],
        "definition": "An infectious disease that arises from reactivation of a virus from a latent phase to a lytic phase."
      },
      "child_count": 3,
      "reference_id": "MONDO:0100330"
    }
  ],
  "children": [
    {
      "id": 7389,
      "label": "geniculate herpes zoster",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7250,
        7300,
        20716,
        21351
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9210",
          "EFO:0007281",
          "GARD:0007525",
          "ICD9:053.11",
          "ICD9:351.8",
          "MEDGEN:6581",
          "NCIT:C84763",
          "NORD:1647",
          "Orphanet:3020",
          "SCTID:95670000",
          "UMLS:C0017409"
        ],
        "synonyms": [
          "Herpes Zoster Oticus",
          "Ramsay Hunt Syndrome",
          "Ramsay Hunt syndrome",
          "facial nerve palsy due to VZV",
          "facial nerve palsy due to herpes zoster infection",
          "facial nerve paralysis due to VZV",
          "Hunt syndrome (formerly)",
          "Hunt's syndrome (formerly)",
          "Ramsay Hunt syndrome type 2",
          "Ramsay Hunt syndrome type 2 (formerly)",
          "Ramsay Hunt syndrome type II"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A viral ear infection caused by the spread of varicella-zoster virus to the facial nerves. It is characterized by intense otalgia and a cutaneous vesicular eruption."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005769"
    },
    {
      "id": 7488,
      "label": "ophthalmic herpes zoster",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5448,
        7250,
        19708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007403",
          "GARD:0009721",
          "ICD9:053.29",
          "MEDGEN:9236",
          "MESH:D006563",
          "SCTID:87513003",
          "UMLS:C0019364"
        ],
        "synonyms": [
          "herpes zoster ophthalmicus",
          "HZO",
          "Herpes zoster ophthalmicus (HZO)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005883"
    },
    {
      "id": 23270,
      "label": "zoster sine herpete",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7250
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:253902",
          "MESH:D031368",
          "SCTID:449783002",
          "UMLS:C1135841"
        ],
        "synonyms": [
          "zoster sine herpete",
          "Zoster sine Eruptione"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Herpes zoster but without eruption of vesicles. Patients exhibit the characteristic pain minus the skin rash, sometimes making diagnosis difficult."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043988"
    }
  ],
  "roots": [
    {
      "id": 7249,
      "label": "varicella zoster infection"
    },
    {
      "id": 8092,
      "label": "vesiculobullous skin disease"
    },
    {
      "id": 20721,
      "label": "post-viral disorder"
    },
    {
      "id": 21328,
      "label": "skin disorder caused by infection"
    },
    {
      "id": 24063,
      "label": "disease arising from reactivation of latent virus"
    }
  ]
}