{
  "id": 7051,
  "label": "carcinoid tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005369",
  "properties": {
    "xrefs": [
      "EFO:0004243",
      "GARD:0024176",
      "HP:0100570",
      "ICD9:209.60",
      "ICDO:8240/3",
      "ICDO:8241/3",
      "MEDGEN:2838",
      "MESH:D002276",
      "NANDO:2200396",
      "NCIT:C2915",
      "SCTID:443492008",
      "UMLS:C0007095"
    ],
    "synonyms": [
      "NET G1",
      "carcinoid",
      "carcinoid tumor",
      "carcinoid tumor (disease)",
      "carcinoid tumour (disease)",
      "neuroendocrine neoplasm G1",
      "neuroendocrine tumor G1",
      "neuroendocrine tumour G1"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    }
  ],
  "children": [
    {
      "id": 7627,
      "label": "lung carcinoid tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000037",
          "GARD:0024273",
          "MEDGEN:79070",
          "NCIT:C4038",
          "ONCOTREE:LUCA",
          "SCTID:254627002",
          "UMLS:C0280089"
        ],
        "synonyms": [
          "carcinoid tumor (disease) of lung",
          "carcinoid tumor of lung",
          "carcinoid tumor of the lung",
          "carcinoid tumour (disease) of lung",
          "carcinoid tumour of lung",
          "carcinoid tumour of the lung",
          "lung carcinoid tumor",
          "lung carcinoid tumor (disease)",
          "lung carcinoid tumour (disease)",
          "pulmonary carcinoid tumor",
          "pulmonary carcinoid tumour",
          "lung carcinoid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006041"
    },
    {
      "id": 7669,
      "label": "atypical carcinoid tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000097",
          "GARD:0024292",
          "MEDGEN:226834",
          "NCIT:C72074",
          "SCTID:445238008",
          "UMLS:C1266032"
        ],
        "synonyms": [
          "atypical carcinoid tumor",
          "malignant carcinoid tumor",
          "malignant carcinoid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoid tumor characterized by a high mitotic rate, often associated with the presence of necrosis and nuclear pleomorphism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006095"
    },
    {
      "id": 7780,
      "label": "gastric neuroendocrine tumor G1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051,
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000275",
          "GARD:0024341",
          "MEDGEN:83885",
          "NCIT:C4635",
          "UMLS:C0349529"
        ],
        "synonyms": [
          "gastric ECL cell NET",
          "gastric ECL cell NET G1",
          "gastric ECL cell, histamine-producing NET",
          "gastric ECL-cell carcinoid tumor",
          "gastric ECL-cell carcinoid tumour",
          "gastric NET G1",
          "gastric carcinoid tumor",
          "gastric carcinoid tumour",
          "gastric enterochromaffin-like cell carcinoid tumor",
          "gastric enterochromaffin-like cell carcinoid tumour",
          "gastric enterochromaffin-like cell neuroendocrine tumor",
          "gastric enterochromaffin-like cell neuroendocrine tumour",
          "grade 1 neuroendocrine neoplasm of stomach",
          "stomach NET G1",
          "stomach carcinoid tumor",
          "stomach carcinoid tumour",
          "stomach neuroendocrine neoplasm G1",
          "stomach neuroendocrine tumor, well differentiated, low grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the stomach. The vast majority of cases arise from the corpus-fundus region. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. It may be associated with autoimmune chronic atrophic gastritis, multiple endocrine neoplasia type 1, or it may be sporadic."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006227"
    },
    {
      "id": 8401,
      "label": "somatostatinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051,
        19671
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4430",
          "EFO:1001187",
          "GARD:0004900",
          "ICD9:235.5",
          "ICDO:8156/1",
          "MEDGEN:52416",
          "MESH:D013005",
          "MedDRA:10041329",
          "NCIT:C3379",
          "Orphanet:97283",
          "SCTID:253006001",
          "UMLS:C0037661",
          "icd11.foundation:219879696"
        ],
        "synonyms": [
          "Delta cell tumor",
          "Delta cell tumour",
          "somatostatin cell tumor",
          "somatostatin producing tumor",
          "somatostatin producing tumour",
          "somatostatin-producing NET",
          "somatostatin-producing neuroendocrine tumor",
          "somatostatin-producing neuroendocrine tumour",
          "somatostatin-producing tumor",
          "somatostatin-producing tumour",
          "somatostatinoma",
          "tumor of Delta cells",
          "tumor of the Delta cells",
          "tumour of Delta cells",
          "tumour of the Delta cells",
          "Somatomedin-secreting carcinoid",
          "ampullary somatostatinoma",
          "carcinoid somatostatinoma",
          "malignant islet cell tumor",
          "malignant islet cell tumour",
          "somatostatin-secreting pancreatic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, usually malignant neuroendocrine tumor arizing from delta cells. This neoplasm produces large amounts of somatostatin, which may result in a syndrome characterized by diarrhea, steatorrhea, weight loss, and gastric hyposecretion. Sixty percent are found in the pancreas and 40% in the duodenum or jejunum. The peak incidence occurs between 40 and 60 years of age; women are affected more than men by 2:1."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006976"
    },
    {
      "id": 20650,
      "label": "intestinal neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        4896,
        7051
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025331",
          "MEDGEN:138099",
          "MESH:C562842",
          "NCIT:C4637",
          "OMIM:114900",
          "SCTID:276816003",
          "UMLS:C0349535"
        ],
        "synonyms": [
          "carcinoid tumor of intestine",
          "carcinoid tumor of the intestine",
          "carcinoid tumour of intestine",
          "carcinoid tumour of the intestine",
          "grade 1 neuroendocrine neoplasm of intestine",
          "intestinal NET G1",
          "intestinal carcinoid tumor",
          "intestinal carcinoid tumour",
          "intestinal neuroendocrine tumor G1",
          "intestine NET G1",
          "intestine carcinoid tumor",
          "intestine carcinoid tumor (disease)",
          "intestine carcinoid tumour",
          "intestine carcinoid tumour (disease)",
          "intestine neuroendocrine neoplasm G1",
          "intestine neuroendocrine tumor, well differentiated, low grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small or large intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021533"
    },
    {
      "id": 20652,
      "label": "pancreatic neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7051,
        19671
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025333",
          "MEDGEN:459467",
          "NCIT:C95584",
          "SCTID:254613007",
          "UMLS:C2987241"
        ],
        "synonyms": [
          "grade 1 neuroendocrine neoplasm of pancreas",
          "pancreas NET G1",
          "pancreas carcinoid tumor",
          "pancreas carcinoid tumour",
          "pancreas neuroendocrine neoplasm G1",
          "pancreas neuroendocrine tumor, well differentiated, low grade",
          "pancreatic NET G1",
          "pancreatic neuroendocrine tumor G1"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A low grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal or less than 2%."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021535"
    },
    {
      "id": 20921,
      "label": "childhood carcinoid tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051,
        20320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009315",
          "MEDGEN:859267",
          "NCIT:C118810",
          "UMLS:C3899673"
        ],
        "synonyms": [
          "carcinoid tumor (disease) of childhood",
          "carcinoid tumour (disease) of childhood",
          "childhood carcinoid tumor",
          "childhood carcinoid tumor (disease)",
          "childhood carcinoid tumour (disease)",
          "paediatric carcinoid tumour (disease)",
          "pediatric carcinoid tumor (disease)",
          "carcinoid tumor childhood",
          "carcinoid tumour childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare carcinoid tumor that occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022642"
    }
  ],
  "roots": [
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    }
  ]
}