{
  "id": 6997,
  "label": "drug dependence",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005303",
  "properties": {
    "xrefs": [
      "DOID:9974",
      "EFO:0003890",
      "ICD9:304",
      "ICD9:304.6",
      "ICD9:304.60",
      "ICD9:304.90",
      "MEDGEN:307144",
      "NCIT:C3894",
      "SCTID:191816009",
      "UMLS:C1510472"
    ],
    "synonyms": [
      "chemical dependence"
    ],
    "definition": "Drug dependence - replaced the term \"drug addiction\" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6684,
      "label": "substance dependence",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4573
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9973",
          "ICD9:304.60",
          "MEDGEN:20989",
          "NCIT:C35458",
          "SCTID:2403008",
          "UMLS:C0038580"
        ],
        "synonyms": [
          "dependence"
        ],
        "definition": "The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence."
      },
      "child_count": 1,
      "reference_id": "MONDO:0004938"
    }
  ],
  "children": [
    {
      "id": 4448,
      "label": "barbiturate dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2575",
          "ICD9:304.11",
          "ICD9:304.13",
          "MEDGEN:572756",
          "SCTID:231472009",
          "UMLS:C0338767"
        ],
        "definition": "A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002347"
    },
    {
      "id": 6685,
      "label": "hallucinogen dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9977",
          "ICD10CM:F16.2",
          "ICD9:304.5",
          "ICD9:304.50",
          "MEDGEN:5415",
          "NCIT:C34657",
          "SCTID:38247002",
          "UMLS:C0018528",
          "icd11.foundation:2041952725"
        ],
        "definition": "A drug dependence for a hallucinogenic substance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004939"
    },
    {
      "id": 6907,
      "label": "cocaine dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9975",
          "EFO:0002610",
          "ICD10CM:F14.2",
          "ICD9:304.2",
          "ICD9:304.20",
          "MEDGEN:154705",
          "NCIT:C34492",
          "SCTID:31956009",
          "UMLS:C0600427",
          "icd11.foundation:1691013484"
        ],
        "synonyms": [
          "cocaine addiction"
        ],
        "definition": "A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005186"
    },
    {
      "id": 7092,
      "label": "methamphetamine dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004701",
          "MEDGEN:735816",
          "UMLS:C1533217"
        ],
        "definition": "A drug dependence that is a psychological dependency on the regular use of methamphetamine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005419"
    },
    {
      "id": 7099,
      "label": "alcohol and nicotine codependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "definition": "A drug dependence that is the physiological result of being addicted to alcohol and nicotine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005432"
    },
    {
      "id": 7183,
      "label": "opiate dependence",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2559",
          "EFO:0005611",
          "ICD10CM:F11.2",
          "ICD9:304.0",
          "ICD9:304.00",
          "MEDGEN:99372",
          "MESH:D009293",
          "SCTID:75544000",
          "UMLS:C0524662"
        ],
        "synonyms": [
          "opioid dependence",
          "opioid type dependence",
          "narcotism"
        ],
        "definition": "Disorders related or resulting from abuse or mis-use of opioids."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005530"
    },
    {
      "id": 7320,
      "label": "cannabis dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1849",
          "DOID:9505",
          "EFO:0007191",
          "ICD10CM:F12.2",
          "ICD9:304.3",
          "ICD9:304.30",
          "ICD9:305.2",
          "MEDGEN:14303",
          "MESH:D002189",
          "NCIT:C34445",
          "SCTID:37344009",
          "SCTID:85005007",
          "UMLS:C0006870",
          "icd11.foundation:1129015467"
        ],
        "synonyms": [
          "cannabis abuse",
          "marijuana dependence"
        ],
        "definition": "Physical and psychological dependence on the drug cannabis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005689"
    },
    {
      "id": 7514,
      "label": "phencyclidine abuse",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4570,
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5062",
          "ICD9:305.90",
          "MEDGEN:19234",
          "MESH:D010623",
          "SCTID:7071007",
          "UMLS:C0031391"
        ],
        "definition": "The misuse of phencyclidine with associated psychological symptoms and impairment in social or occupational functioning."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005912"
    },
    {
      "id": 8493,
      "label": "alcohol dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997,
        20729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050741",
          "ICD10CM:F10.2",
          "ICD9:303.90",
          "ICD9:305.0",
          "MEDGEN:1801",
          "NCIT:C93040",
          "OMIM:103780",
          "SCTID:66590003",
          "UMLS:C0001973",
          "icd11.foundation:1580466198"
        ],
        "synonyms": [
          "alcohol dependence",
          "alcoholism",
          "aerodigestive tract cancer, squamous cell, alcohol-related, protection against",
          "alcohol dependence, protection against",
          "alcohol dependence, susceptibility to"
        ],
        "definition": "Physical and psychological dependence on alcohol."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007079"
    },
    {
      "id": 9861,
      "label": "nicotine dependence",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6997
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050742",
          "EFO:0003768",
          "ICD10CM:F17",
          "ICD10CM:F17.2",
          "ICD9:305.1",
          "MEDGEN:45086",
          "MESH:D014029",
          "NCIT:C54203",
          "SCTID:56294008",
          "UMLS:C0028043",
          "icd11.foundation:1699574100"
        ],
        "synonyms": [
          "nicotine addiction",
          "tobacco use disorder"
        ],
        "definition": "Physical and psychological dependence on nicotine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008575"
    }
  ],
  "roots": [
    {
      "id": 6684,
      "label": "substance dependence"
    }
  ]
}