{
  "id": 6913,
  "label": "prostate intraepithelial neoplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005193",
  "properties": {
    "xrefs": [
      "EFO:0002621",
      "ICD10CM:N42.31",
      "MEDGEN:76480",
      "MESH:D019048",
      "NCIT:C4064",
      "SCTID:254901000",
      "UMLS:C0282612"
    ],
    "synonyms": [
      "PIN",
      "pin",
      "pin - prostatic intraepithelial neoplasia",
      "prostate intraepithelial neopl.",
      "prostate intraepithelial neoplasia (pin)",
      "prostatic intraepithelial neoplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland. The neoplastic epithelial cells are confined within the acini and the ducts and they do not invade the surrounding prostatic stroma. Morphologically, it is classified as low or high grade."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 20463,
      "label": "prostate neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5087,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13206",
          "ICD9:600.1",
          "MEDGEN:18697",
          "NCIT:C3343",
          "ONCOTREE:PROSTATE",
          "UMLS:C0033578"
        ],
        "synonyms": [
          "neoplasm of prostate",
          "neoplasm of prostate gland",
          "neoplasm of the prostate",
          "prostate gland neoplasm",
          "prostate gland neoplasm (disease)",
          "prostate gland tumor",
          "prostate gland tumour",
          "prostate tumor",
          "prostate tumour",
          "tumor of prostate",
          "tumor of prostate gland",
          "tumor of the prostate",
          "tumour of prostate",
          "tumour of prostate gland",
          "tumour of the prostate",
          "nodular prostate",
          "prostate nodule"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the prostate gland."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021259"
    },
    {
      "id": 21429,
      "label": "intraepithelial neoplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:164203",
          "NCIT:C8366",
          "UMLS:C0878500"
        ],
        "synonyms": [
          "epithelial dysplasia",
          "intraepithelial neoplasia",
          "intraepithelial neoplasm"
        ],
        "definition": "A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024474"
    }
  ],
  "children": [
    {
      "id": 7787,
      "label": "grade III prostatic intraepithelial neoplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6433,
        6882,
        6913
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8634",
          "EFO:1000283",
          "ICD10CM:D07.5",
          "ICD9:233.4",
          "MEDGEN:1684800",
          "NCIT:C3642",
          "SCTID:92691004",
          "UMLS:C5200982"
        ],
        "synonyms": [
          "PIN III",
          "adenocarcinoma in situ of prostate",
          "adenocarcinoma in situ of the prostate",
          "carcinoma in situ of prostate",
          "carcinoma in situ of prostate gland",
          "grade 3 pin",
          "grade 3 prostatic intraepithelial neoplasia",
          "grade III pin",
          "pin III",
          "prostate adenocarcinoma in situ",
          "prostate carcinoma in situ",
          "prostate gland carcinoma in situ",
          "prostate gland in situ carcinoma",
          "stage 0 prostate gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "High grade prostatic intraepithelial neoplasia characterized by the presence of severe architectural and cytologic abnormalities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006234"
    }
  ],
  "roots": [
    {
      "id": 20463,
      "label": "prostate neoplasm"
    },
    {
      "id": 21429,
      "label": "intraepithelial neoplasia"
    }
  ]
}