{
  "id": 6899,
  "label": "osteoarthritis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005178",
  "properties": {
    "xrefs": [
      "DOID:8398",
      "HP:0002758",
      "ICD10CM:M15-M19",
      "ICD10CM:M19",
      "ICD9:715.3",
      "MEDGEN:45244",
      "MESH:D010003",
      "NCIT:C3293",
      "SCTID:396275006",
      "UMLS:C0029408",
      "icd11.foundation:558562409"
    ],
    "synonyms": [
      "degenerative joint disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7223,
      "label": "arthritic joint disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4665,
        8264,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:848",
          "EFO:0005856",
          "MEDGEN:2043",
          "MESH:D001168",
          "NCIT:C2883",
          "SCTID:3723001",
          "UMLS:C0003864",
          "Wikipedia:Arthritis"
        ],
        "synonyms": [
          "arthritis",
          "inflammation of skeletal joint",
          "skeletal joint inflammation",
          "inflammatory disorder of joint"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain."
      },
      "child_count": 39,
      "reference_id": "MONDO:0005578"
    }
  ],
  "children": [
    {
      "id": 7089,
      "label": "osteoarthritis, knee",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6899
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004616",
          "MEDGEN:98371",
          "MESH:D020370",
          "UMLS:C0409959"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005416"
    },
    {
      "id": 8101,
      "label": "osteoarthritis, hip",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6899
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000786",
          "MEDGEN:14530",
          "MESH:D015207",
          "NCIT:C34876",
          "UMLS:C0029410"
        ],
        "synonyms": [
          "hip osteoarthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006629"
    },
    {
      "id": 8102,
      "label": "osteoarthritis, spine",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6899
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000787",
          "MEDGEN:389941",
          "MESH:D055013",
          "SCTID:8847002",
          "UMLS:C2350242"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A degenerative joint disease involving the spine. It is characterized by progressive deterioration of the spinal articular cartilage (cartilage, articular), usually with hardening of the subchondral bone and outgrowth of bone spurs (osteophyte)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006630"
    },
    {
      "id": 8103,
      "label": "osteoarthritis, toe",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6899
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:592722",
          "UMLS:C0409929"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Osteoarthritis of the foot generally affects the joint at the base of your big toe. It can cause your toe to: - become stiff over time, which can make it difficult and painful to walk – this is called hallux rigidus - become bent, which can lead to painful bunions (bony lumps at the base of your big toe) – this is called hallux valgus. Osteoarthritis of the mid-foot is also quite common, especially in older people, and may cause an obvious bony swelling (osteophyte) on the top of your mid-foot. Ankle osteoarthritis is least common and may cause your heel to move to an unusual angle."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006631"
    },
    {
      "id": 8104,
      "label": "osteoarthritis, hand",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6899
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000789",
          "MEDGEN:472992",
          "UMLS:C0263746"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Osteoarthritis of the hands usually happens as part of nodal osteoarthritis (a form of osteoarthritis that runs in families). This mainly affects women and often starts in your 40s or 50s, around the menopause (the time when menstruation ends and it’s no longer possible to have children)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006632"
    }
  ],
  "roots": [
    {
      "id": 7223,
      "label": "arthritic joint disease"
    }
  ]
}