{ "id": 6834, "label": "viral infectious disease", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0005108", "properties": { "xrefs": [ "DOID:934", "EFO:0000763", "ICD9:060-066", "ICD9:066.9", "ICD9:078.89", "ICD9:079.99", "MESH:D014777", "NCIT:C3439", "SCTID:34014006" ], "synonyms": [ "Viruses caused disease or disorder", "Viruses disease or disorder", "Viruses infection", "Viruses infectious disease", "infection, viral", "viral disease", "viral disorder", "viral infection", "infections, Viruses" ], "definition": "Any disease caused by a virus." }, "isLeaf": false, "isRoot": false, "child_count": 42, "parents": [ { "id": 7200, "label": "infectious disease", "isLeaf": false, "isRoot": false, "parents": [ 29383 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050117", "EFO:0005741", "ICD10CM:A00-B99", "ICD9:079.0", "ICD9:136.8", "ICD9:136.9", "IDO:0000436", "MEDGEN:1057", "MESH:D003141", "NCIT:C26726", "SCTID:40733004", "UMLS:C0009450" ], "synonyms": [ "communicable disease", "infection", "infectious", "infectious disease", "infectious diseases and manifestations", "infectious disorder", "transmissible disease", "clinical infection", "disease by infectious agent" ], "definition": "A disorder directly resulting from the presence and activity of a microbial, viral, or parasitic agent in humans. It can be transmitted by direct or indirect contact." }, "child_count": 35, "reference_id": "MONDO:0005550" } ], "children": [ { "id": 2813, "label": "Whitewater Arroyo hemorrhagic fever", "isLeaf": true, "isRoot": false, "parents": [ 6834, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050199" ], "definition": "A viral infectious disease that is a hemorrhagic fever, has material basis in Whitewater Arroyo virus, which is transmitted by white-throated woodrats (Neotoma albigula). The infection has symptom fever, has symptom headache, has symptom myalgia, and has symptom hemorrhagic manifestations." }, "child_count": 0, "reference_id": "MONDO:0000282" }, { "id": 2851, "label": "exanthema subitum", "isLeaf": true, "isRoot": false, "parents": [ 6834, 8030, 21328 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050495", "EFO:1001320", "ICD10CM:B08.2", "ICD9:057.8", "ICD9:058.1", "ICD9:058.10", "MEDGEN:41909", "MESH:D005077", "NCIT:C128420", "SCTID:54385001", "UMLS:C0015231", "icd11.foundation:1883970802" ], "synonyms": [ "exanthem subitum", "roseola", "roseola Infantum", "sixth disease", "pseudorubella" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "An infection that is due to human herpesvirus (HHV) types 6 or 7; it is characterized by 3-5 days of high fever followed by the acute onset of a rosy, pink, non-pruritic, macular rash that is predominantly on the neck and trunk." }, "child_count": 0, "reference_id": "MONDO:0000337" }, { "id": 3170, "label": "Zika virus congenital syndrome", "isLeaf": true, "isRoot": false, "parents": [ 6834, 20719, 20721, 23869 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080180", "GARD:0013441", "MEDGEN:1622152", "UMLS:C4546023", "icd11.foundation:755611612" ], "synonyms": [ "congenital Zika syndrome", "congenital Zika virus infection" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" } ], "definition": "A congenital birth syndrome that arises from materal Zika infection." }, "child_count": 0, "reference_id": "MONDO:0000890" }, { "id": 3449, "label": "common wart", "isLeaf": true, "isRoot": false, "parents": [ 6834, 21328, 21573 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11165", "EFO:0009662", "ICD10CM:B07", "ICD9:078.1", "ICD9:078.10", "ICD9:078.19", "MEDGEN:777120", "MESH:D014860", "NCIT:C27087", "SCTID:57019003", "UMLS:C3665596", "icd11.foundation:1074706780" ], "synonyms": [ "common wart", "verruca vulgaris", "viral Warts", "viral Warts due to papilloma virus", "viral wart", "wart" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A wart caused by human papillomavirus. It can appear anywhere on the skin." }, "child_count": 0, "reference_id": "MONDO:0001209" }, { "id": 3715, "label": "viral labyrinthitis", "isLeaf": true, "isRoot": false, "parents": [ 4163, 6834, 20716 ], "type_id": 0, "properties": { "xrefs": [ "DOID:12357", "ICD10CM:A88.1", "ICD9:386.35", "MEDGEN:509997", "SCTID:409711008", "UMLS:C0155508" ], "synonyms": [ "Viruses caused labyrinthitis", "Viruses labyrinthitis", "epidemic vertigo", "epidemic vertigo (finding)" ], "categories": [ { "ref": "MONDO:0002409", "name": "auditory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "An labyrinthitis caused by infection with Viruses." }, "child_count": 0, "reference_id": "MONDO:0001507" }, { "id": 4385, "label": "viral gastritis", "isLeaf": false, "isRoot": false, "parents": [ 6709, 6834, 23208 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2327", "ICD9:008.8", "MEDGEN:107873", "NCIT:C27184", "SCTID:285344007", "UMLS:C0563238" ], "synonyms": [ "Viruses caused gastritis (disease)", "Viruses gastritis (disease)", "viral gastritis" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "Inflammation of the stomach resulting from viral infection." }, "child_count": 3, "reference_id": "MONDO:0002270" }, { "id": 4652, "label": "vaccinia", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3298", "ICD9:999.0", "MEDGEN:52964", "MESH:D014615", "SCTID:111852003", "UMLS:C0042214", "icd11.foundation:1275065853" ], "definition": "The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine." }, "child_count": 0, "reference_id": "MONDO:0002595" }, { "id": 5713, "label": "viral esophagitis", "isLeaf": true, "isRoot": false, "parents": [ 3630, 6834, 23208 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6297", "MEDGEN:87414", "NCIT:C27108", "SCTID:235603003", "UMLS:C0341110" ], "synonyms": [ "Viruses caused esophagitis (disease)", "Viruses esophagitis (disease)", "viral esophagitis" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "Viral infection of the esophagus. It often occurs in immunocompromised patients and it is caused by cytomegalovirus or herpes simplex virus. Symptoms include pain on swallowing, fever, and retrosternal burning." }, "child_count": 0, "reference_id": "MONDO:0003846" }, { "id": 6785, "label": "Kaposi's sarcoma", "isLeaf": false, "isRoot": false, "parents": [ 6834, 16085, 17394 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8632", "EFO:0000558", "GARD:0006814", "HP:0100726", "ICD10CM:C46", "ICD9:176", "ICD9:176.8", "ICD9:176.9", "ICDO:9140/3", "MEDGEN:11321", "MESH:D012514", "MedDRA:10023284", "NCIT:C9087", "Orphanet:33276", "SCTID:109385007", "UMLS:C0036220" ], "synonyms": [ "KS", "Kaposi sarcoma", "Kaposi's sarcoma", "Kaposi's sarcoma (disease)", "Kaposi's sarcoma of anus", "Kaposi's sarcoma of central nervous system", "Kaposi's sarcoma of esophagus", "Kaposi's sarcoma of gastrointestinal sites", "Kaposi's sarcoma of heart", "Kaposi's sarcoma of lymph nodes", "Kaposi's sarcoma of oesophagus", "Kaposi's sarcoma of penis", "Kaposi's sarcoma of skin", "Kaposi's sarcoma of the CNS", "Kaposi's sarcoma of the gallbladder", "Kaposi's sarcoma of the prostate", "Kaposi's sarcoma, lung", "Kaposi's sarcoma, skin", "anal Kaposi's sarcoma", "cardiac Kaposi's sarcoma", "central nervous system Kaposi's sarcoma", "conjunctival Kaposi's sarcoma", "corneal Kaposi's sarcoma", "cutaneous Kaposi's sarcoma", "esophageal Kaposi's sarcoma", "gallbladder Kaposi's sarcoma", "gastric Kaposi's sarcoma", "intestinal Kaposi's sarcoma", "lymph node Kaposi's sarcoma", "lymphadenopathic Kaposi's sarcoma", "multiple hemorrhagic sarcoma", "palate Kaposi's sarcoma", "penis Kaposi's sarcoma", "prostate Kaposi's sarcoma", "pulmonary Kaposi's sarcoma", "soft tissue Kaposi's sarcoma", "HHV8", "KSHV", "Kaposi sarcoma herpesvirus", "Mediterranean Kaposi sarcoma", "human herpesvirus 8", "non AIDS related Kaposi sarcoma" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" } ], "definition": "A malignant neoplasm characterized by a vascular proliferation which usually contains blunt endothelial cells. Erythrocyte extravasation and hemosiderin deposition are frequently present. The most frequent site of involvement is the skin; however it may also occur internally. It generally develops in people with compromised immune systems including those with acquired immune deficiency syndrome (AIDS)." }, "child_count": 12, "reference_id": "MONDO:0005055" }, { "id": 7345, "label": "contagious pustular dermatitis", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8771", "EFO:0007222", "ICD10CM:B08.02", "ICD9:051.2", "MEDGEN:41702", "MESH:D004474", "SCTID:74050005", "UMLS:C0013570" ], "synonyms": [ "ecthyma contagiosum", "ecthyma, Contagious" ], "definition": "An infectious dermatitis of sheep and goats, affecting primarily the muzzle and lips. It is caused by a poxvirus and may be transmitted to humans." }, "child_count": 0, "reference_id": "MONDO:0005717" }, { "id": 7347, "label": "Coronavinae infectious disease", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0007224", "MESH:D018352" ], "definition": "Virus diseases caused by the coronavirus genus. Some specifics include transmissible enteritis of turkeys (enteritis, transmissible, of turkeys); feline infectious peritonitis; and transmissible gastroenteritis of swine (gastroenteritis, transmissible, of swine)." }, "child_count": 0, "reference_id": "MONDO:0005719" }, { "id": 7372, "label": "epidemic pleurodynia", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10882", "ICD10CM:B33.0", "ICD9:074.1", "MEDGEN:19355", "MESH:D011000", "SCTID:83264000", "UMLS:C0032238" ], "synonyms": [ "Bornholm disease", "epidemic myalgia" ], "definition": "An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses." }, "child_count": 0, "reference_id": "MONDO:0005751" }, { "id": 7409, "label": "herpangina", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10883", "EFO:0007306", "ICD10CM:B08.5", "ICD9:074.0", "MEDGEN:42435", "MESH:D006557", "SCTID:274102007", "UMLS:C0019338" ], "definition": "A viral infectious disease that results in infection located in mouth, has material basis in Human coxsackievirus A16, has material basis in Human enterovirus 71, has material basis in group B coxsackievirus, or has material basis in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars." }, "child_count": 0, "reference_id": "MONDO:0005791" }, { "id": 7417, "label": "human T-lymphotropic virus 1 infectious disease", "isLeaf": false, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0007316", "GARD:0009645", "MEDGEN:6919", "MESH:D015490", "UMLS:C0020097" ], "synonyms": [ "Human T-lymphotropic virus 1 caused disease or disorder", "Human T-lymphotropic virus 1 disease or disorder", "Human T-lymphotropic virus 1 infectious disease", "human T-lymphotropic virus 1 infectious disease", "HTLV-1", "Human T lymphotropic virus type 1" ], "definition": "A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder." }, "child_count": 2, "reference_id": "MONDO:0005801" }, { "id": 7444, "label": "lumpy skin disease", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0007349", "MEDGEN:9815", "MESH:D008166", "UMLS:C0024106" ], "definition": "A poxvirus infection of cattle characterized by the appearance of nodules on all parts of the skin." }, "child_count": 0, "reference_id": "MONDO:0005830" }, { "id": 7461, "label": "milker's nodule", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8729", "ICD9:051.1", "ICD9:051.9", "MEDGEN:44449", "MESH:D011213", "SCTID:27240009", "UMLS:C0026143" ], "synonyms": [ "Pseudocowpox" ], "definition": "Virus diseases caused by the poxviridae." }, "child_count": 0, "reference_id": "MONDO:0005850" }, { "id": 7466, "label": "molluscum contagiosum", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8867", "EFO:0007375", "ICD10CM:B08.1", "ICD9:078.0", "MEDGEN:10081", "MESH:D008976", "SCTID:40070004", "UMLS:C0026393", "icd11.foundation:82201615" ], "definition": "A common, benign, usually self-limited viral infection of the skin and occasionally the conjunctivae by a poxvirus (molluscum contagiosum virus). (Dorland, 27th ed)" }, "child_count": 0, "reference_id": "MONDO:0005855" }, { "id": 7482, "label": "Newcastle disease", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2929", "EFO:0007395", "MEDGEN:10339", "MESH:D009521", "NCIT:C34849", "UMLS:C0027983" ], "definition": "A condition caused by infection by the Newcastle disease virus, which may be characterized by conjunctivitis, respiratory illness, and diarrhea." }, "child_count": 0, "reference_id": "MONDO:0005875" }, { "id": 7513, "label": "pharyngoconjunctival fever", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13801", "ICD9:077.2", "MEDGEN:14722", "MESH:D000258", "NCIT:C34924", "SCTID:70385007", "UMLS:C0031351" ], "synonyms": [ "pharyngoconjunctival fever" ], "definition": "A condition characterized by fever, conjunctivitis, and pharyngitis resulting from infection by adenovirus." }, "child_count": 0, "reference_id": "MONDO:0005911" }, { "id": 7530, "label": "pseudorabies", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0007457", "MEDGEN:18730", "MESH:D011557", "UMLS:C0033839" ], "definition": "A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals." }, "child_count": 0, "reference_id": "MONDO:0005932" }, { "id": 7535, "label": "Reoviridae infectious disease", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0007464", "MEDGEN:48410", "MESH:D012088", "UMLS:C0035112" ], "synonyms": [ "Reoviridae infection", "Reovirus infection", "Reovirus infections", "infection, Reoviridae", "infection, Reovirus", "infections, Reoviridae", "infections, Reovirus" ], "definition": "Infections produced by reoviruses, general or unspecified." }, "child_count": 0, "reference_id": "MONDO:0005939" }, { "id": 10437, "label": "immunodeficiency 32B", "isLeaf": true, "isRoot": false, "parents": [ 5714, 6834, 20721 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111985", "GARD:0009534", "MEDGEN:1668246", "NANDO:2200808", "OMIM:226990", "OMIM:614894", "Orphanet:2566", "UMLS:C4751209" ], "synonyms": [ "CAEBV syndrome", "IMD32B", "IRF8 deficiency, autosomal recessive", "chronic EBV infection syndrome", "chronic Epstein-Barr virus infection syndrome", "immunodeficiency 32B", "immunodeficiency 32B, monocyte, Dendritic cell, and natural Killer cell deficiency, autosomal recessive", "monocyte and dendritic cell deficiency, autosomal recessive", "CAEBV infection", "CEBV", "Epstein-Barr VIRUS, susceptibility to chronic infection by", "chronic active Epstein-Barr disease", "chronic active Epstein-Barr virus infection" ], "definition": "A rare progressive disease that begins as a primary Epstein-Barr virus (EBV) infection. In this type of infection, the body makes too many lymphocytes (lymphoproliferative disease) for a period of more than 6 months duration. Lymphocytes are a type of white blood cell. They are an importantpart ofthe immune system because they help fight off diseases and protect the body from infection byproducing antibodies against viruses or bacteria and regulating immune responses. In CAEBV there are many antibodies againstEBV in the blood.Most people (about 95% of adults) get infected with EBV at some point in their lives, and never have any health problems.However, EBV can cause infectiousmononucleosis and other illnesses, and has a role in various autoimmune diseases and some types of cancer. While most infections occurring during childhood do not cause any symptoms,EBV infection in adolescents or young adults can often result in mononucleosis.After an EBV infection, the virus becomes latent (inactive) in the body, and, in some cases, the virus may reactivate. This does not always cause symptoms, but people with weakened immune systems are more likely to develop symptoms if EBV reactivates.In rare cases, people infected with EBV develop chronic active EBV virus infection(CAEBV) without apparent immunodeficiency. Most cases of CAEBV have been reported from Japan. These patientshave some of the complications found in otherwise-healthy patients with acute EBV infection, but unlike healthy patients, these complications persist and progress. Symptoms of CAEBV most often include fever, liverdysfunction, an enlarged spleen (splenomegaly), swollen lymph nodes (lymphadenopathy), and low numbers of platelets (thrombocytopenia) as well as high EBV-DNA load in the blood. Other features that appear in more than 10% of patients include enlarged liver (hepatomegaly), anemia, hypersensitivity to mosquito bites, rash, oral ulcers, hemophagocytic syndrome, coronary artery aneurysms, liver failure, lymphoma, and interstitial pneumonia. While the cause is yet unknown, researchers have identified defects in T cells or natural killer (NK) cells activity which results in a decreased defense against the EBV in people with CAEBV.It is important to note that the fatigue and malaise from acute infectious mononucleosis (IM)varies from mild symptoms lasting only a few weeks, to more severe symptoms of fatigue that can persist for several months, or even up to a year or more in up to 10% of patients (which may be considered a less severe form of chronicEBV infection). The persistence of fatigue that is seen in some patients after acute IM would lead some people to believe that EBV may also cause cases of chronic fatigue syndrome (CFS). However, no convincing link has been found between EBV and CFS.Hematopoietic stemcell transplantation has shown promise in the treatment of CAEBV." }, "child_count": 0, "reference_id": "MONDO:0009194" }, { "id": 10480, "label": "focal epithelial hyperplasia", "isLeaf": true, "isRoot": false, "parents": [ 5714, 6775, 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5362", "EFO:0007275", "ICD9:528.79", "MEDGEN:60066", "MESH:D017573", "NCIT:C97083", "OMIM:229045", "SCTID:6121001", "UMLS:C0206067" ], "synonyms": [ "heck disease", "FEH, oral", "focal epithelial hyperplasia, oral" ], "definition": "Hyperplasia characterized by the presence of a focal proliferation of epithelial cells." }, "child_count": 0, "reference_id": "MONDO:0009237" }, { "id": 16728, "label": "neurolymphomatosis", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0020354", "MEDGEN:1642312", "MESH:D000077162", "MESH:D008380", "Orphanet:206586", "SCTID:766752000", "UMLS:C4553088", "icd11.foundation:177999927" ], "synonyms": [ "Marek disease", "Marek's disease", "fowl paralyses", "fowl paralysis", "fowl paralyzes" ], "definition": "A transmissible viral disease of birds caused by avian herpesvirus 2 (herpesvirus 2, gallid) and other mardivirus. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye." }, "child_count": 0, "reference_id": "MONDO:0016101" }, { "id": 16739, "label": "viral myositis", "isLeaf": true, "isRoot": false, "parents": [ 6834, 20400 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0020377", "ICD9:729.1", "MEDGEN:508472", "MedDRA:10051512", "Orphanet:206991", "SCTID:240105009", "UMLS:C0150005", "icd11.foundation:864399177" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0016126" }, { "id": 16966, "label": "virus-associated trichodysplasia spinulosa", "isLeaf": true, "isRoot": false, "parents": [ 6834, 21328 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0020592", "MEDGEN:1432798", "Orphanet:228379", "UMLS:C3267126" ], "synonyms": [ "Cyclosporine-induced folliculodystrophy", "TS", "VATS", "pilomatrix dysplasia", "trichodysplasia spinulosa" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "Virus-associated trichodysplasia spinulosa is a rare infectious skin disease characterized by the development of follicular papules with keratin spicules in various parts of the body, predominantly in the face (e.g. nose, eyebrows, auricles), that is due to polyomavirus infection in immunocompromized patients." }, "child_count": 0, "reference_id": "MONDO:0016455" }, { "id": 17645, "label": "infective dermatitis associated with HTLV-1", "isLeaf": true, "isRoot": false, "parents": [ 6834, 21328 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0021135", "MEDGEN:895843", "NCIT:C129260", "Orphanet:289347", "UMLS:C4274291" ], "synonyms": [ "IDH", "IDH Gene family", "infective dermatitis associated with human T-lymphotropic virus type 1", "infective dermatitis associated with human T-lymphotropic virus type I", "isocitrate dehydrogenase Gene family" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A rare and severe chronic disease characterized by recurrent chronic eczema (with erythematous, scaly and crusted lesions) mainly affecting seborrheic areas (e.g. scalp, forehead, eyelids, paranasal and periauricular skin, neck, axillae, and groin), a generalized fine papular rash, chronic nasal discharge with crusting of the anterior nares, and non-virulent Staphylococcus aureus or beta-hemolytic Streptococcus infections, thought to be a result of HTLV-1-induced immunosuppression. Lymphadenopathy, anemia, mild to moderate pruritus and increased incidence of other infections (e.g. crusted scabies) have also been reported in some patients. Patients may subsequently develop other HTLV-1 associated conditions such as adult T-cell leukemia/lymphoma and tropical spastic paraparesis." }, "child_count": 0, "reference_id": "MONDO:0017326" }, { "id": 17683, "label": "congenital varicella syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4370, 6834, 17014 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0000045", "ICD9:771.2", "MEDGEN:87473", "NCIT:C116800", "NORD:1003", "Orphanet:291", "SCTID:277644009", "UMLS:C0343560", "icd11.foundation:2071159826" ], "synonyms": [ "antenatal varicella virus infection", "mother-to-child transmission of varicella syndrome", "Varicella embryopathy", "Varicella virus antenatal infection", "fetal effects of chickenpox", "fetal effects of varicella zoster virus", "fetal varicella infection", "fetal varicella zoster syndrome", "foetal effects of chickenpox", "foetal effects of varicella zoster virus", "foetal varicella infection", "foetal varicella zoster syndrome" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" } ], "definition": "Fetal varicella syndrome (CVS) is an acquired developmental anomaly syndrome characterized by skin, neurological, ocular, limbs and growth defects secondary to maternal Varicella-Zoster Virus (VZV) infection." }, "child_count": 0, "reference_id": "MONDO:0017372" }, { "id": 18247, "label": "viral hemorrhagic fever", "isLeaf": false, "isRoot": false, "parents": [ 6834, 24379 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0005494", "MEDGEN:9213", "MESH:D006482", "NCIT:C36170", "Orphanet:341", "SCTID:240523007", "UMLS:C0019104" ], "synonyms": [ "haemorrhagic fever", "hemorrhagic fever", "hemorrhagic fevers", "VHF", "VHFs", "haemorrhagic fevers, viral", "viral haemorrhagic fever" ], "definition": "A viral infectious disease caused by RNA viruses in the Arenaviridae, Bunyaviridae, Filoviridae, or Flaviviridae family, and characterized by a severe multisystem syndrome, with damage to the vascular system and hemorrhaging." }, "child_count": 32, "reference_id": "MONDO:0018087" }, { "id": 18253, "label": "arbovirus fever", "isLeaf": false, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0018690", "MEDGEN:1826163", "Orphanet:344", "UMLS:C1388359" ], "synonyms": [ "arbovirus fever", "Arbovirosis" ], "definition": "Arbovirosis are polymorphic diseases caused by arboviruses and are classically characterized by encephalitis and hemorrhage, however, most commonly only aspecific fever is observed." }, "child_count": 2, "reference_id": "MONDO:0018093" }, { "id": 18587, "label": "human infection by orthopoxvirus", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0021822", "MEDGEN:734973", "Orphanet:438279", "UMLS:C1532229" ] }, "child_count": 0, "reference_id": "MONDO:0018583" }, { "id": 18983, "label": "congenital Epstein-Barr virus infection", "isLeaf": true, "isRoot": false, "parents": [ 6834, 17014 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0018903", "MEDGEN:908580", "Orphanet:70596", "SCTID:716660007", "UMLS:C4274357", "icd11.foundation:1861788994" ], "synonyms": [ "antenatal EBV infection", "antenatal Epstein-Barr virus infection", "congenital EBV infection", "mother-to-child transmission of Epstein-Barr virus infection" ], "definition": "Congenital Epstein-Barr virus (EBV) infection causes no clinical manifestations in the majority of infants. Indeed, the occurrence of congenital infection with EBV has never been demonstrated conclusively and must be very rare. One case have been reported to present after birth, multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), dystrophy, generalized hypotonia, hepatosplenomegaly, diffuse petechiae and hematomas and multiple areas of metaphysitis of the long bones at birth. A low birth weight was also reported. No specific follow-up of the fetus is recommended following maternal EBV primary-infection." }, "child_count": 0, "reference_id": "MONDO:0019094" }, { "id": 19048, "label": "rabies", "isLeaf": true, "isRoot": false, "parents": [ 6834, 19708 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11260", "GARD:0007516", "ICD10CM:A82", "ICD10WHO:A82", "ICD9:071", "MEDGEN:48308", "MESH:D011818", "MedDRA:10037742", "NCIT:C28182", "NORD:1644", "Orphanet:770", "SCTID:14168008", "UMLS:C0034494", "icd11.foundation:854762584" ], "synonyms": [ "lyssa" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Rabies is a viral zoonosis leading to a fatal encephalopathy if not treated." }, "child_count": 0, "reference_id": "MONDO:0019173" }, { "id": 20137, "label": "arbovirus infection", "isLeaf": true, "isRoot": false, "parents": [ 6834, 23869 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1001269", "MEDGEN:389", "MESH:D001102", "NCIT:C34396", "SCTID:40610006", "UMLS:C0003723" ], "synonyms": [ "arbovirus infection", "arthropod-borne viral infection", "ARBOVIRUS INFECT", "Arboviral disease", "Arbovirus Infection", "Arbovirus Infections", "Arbovirus infection", "Arthropod-Borne Viral Infection", "Arthropod-borne viral infection", "Infection, Arbovirus", "Infections, Arbovirus" ], "definition": "A viral infection that is transmitted by an arthropod." }, "child_count": 0, "reference_id": "MONDO:0020731" }, { "id": 20248, "label": "viral eye infection", "isLeaf": false, "isRoot": false, "parents": [ 6834, 23257 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:8753", "MESH:D015828", "SCTID:312132001", "UMLS:C0015407" ], "synonyms": [ "viral eye infection", "EYE INFECT VIRAL", "Eye Infection, Viral", "Eye Infections, Viral", "Infection, Viral Eye", "Infection, Viral Ocular", "Infections, Viral Eye", "Infections, Viral Ocular", "OCULAR INFECT VIRAL", "Ocular Infection, Viral", "Ocular Infections, Viral", "VIRAL EYE INFECT", "Viral Eye Infection", "Viral Eye Infections", "Viral Ocular Infection", "Viral Ocular Infections", "Viral eye infection" ], "categories": [ { "ref": "MONDO:0002022", "name": "disorder of orbital region" }, { "ref": "MONDO:0024458", "name": "disorder of visual system" } ], "definition": "Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus." }, "child_count": 10, "reference_id": "MONDO:0020950" }, { "id": 21351, "label": "viral infection of central nervous system", "isLeaf": false, "isRoot": false, "parents": [ 6834, 21534 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025391", "ICD10CM:A80-A89", "ICD10WHO:A80-A89", "MEDGEN:91141", "MESH:D020805", "SCTID:302810003", "UMLS:C0348165" ], "synonyms": [ "viral infection of central nervous system", "central nervous system viral infection", "viral disease of central nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ] }, "child_count": 14, "reference_id": "MONDO:0024318" }, { "id": 21376, "label": "viral respiratory tract infection", "isLeaf": false, "isRoot": false, "parents": [ 6834, 21378 ], "type_id": 0, "properties": { "xrefs": [ "ICD9:519.8", "MEDGEN:163755", "NCIT:C27219", "SCTID:312133006", "UMLS:C0877203" ], "synonyms": [ "viral respiratory tract infection" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus." }, "child_count": 12, "reference_id": "MONDO:0024352" }, { "id": 21676, "label": "Parvoviridae infectious disease", "isLeaf": false, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "ICD9:078.89", "MESH:D010322", "SCTID:83223005" ], "synonyms": [ "Parvoviridae caused disease or disorder", "Parvoviridae disease or disorder", "disease due to Parvoviridae", "Parvoviridae infection", "Parvovirus infection", "Parvovirus infections", "disease caused by Parvoviridae", "infection, Parvoviridae", "infection, Parvovirus", "infections, Parvoviridae", "infections, Parvovirus" ], "definition": "Virus infections caused by the parvoviridae." }, "child_count": 2, "reference_id": "MONDO:0025371" }, { "id": 23905, "label": "COVID-19–associated multisystem inflammatory syndrome in children", "isLeaf": true, "isRoot": false, "parents": [ 6834, 22831 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080711", "GARD:0026069", "NCIT:C172127" ], "synonyms": [ "COVID-19 -related paediatric inflammatory multisystem syndrome", "COVID-19 -related pediatric inflammatory multisystem syndrome", "COVID-19 Kawasaki-like syndrome", "COVID-19 associated multisystem inflammatory syndrome in children", "MIS-C", "PIMS", "PIMS-TS", "PMIS", "SARS-CoV-2 Kawasaki-like syndrome", "multisystem inflammatory syndrome in children", "multisystem inflammatory syndrome in children associated with COVID-19", "multisystem inflammatory syndrome in children associated with coronavirus disease 2019", "paediatric inflammatory multisystem syndrome", "paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2", "paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2", "paediatric multi-system inflammatory syndrome potentially associated with COVID-19", "paediatric multisystem inflammatory syndrome", "pediatric inflammatory multisystem syndrome", "pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2", "pediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2", "pediatric multi-system inflammatory syndrome potentially associated with COVID-19", "pediatric multisystem inflammatory syndrome" ], "definition": "A inflammatory syndrome in children infected by the SARS-CoV-2 with similarities to Kawasaki disease. Clinical manifestations range from fever and inflammation to myocardial injury, shock, and development of coronary artery aneurysms." }, "child_count": 0, "reference_id": "MONDO:0100163" }, { "id": 24062, "label": "primary viral infectious disease", "isLeaf": false, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "definition": "The initial viral infectious disase that causes illness." }, "child_count": 32, "reference_id": "MONDO:0100329" }, { "id": 24063, "label": "disease arising from reactivation of latent virus", "isLeaf": false, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "synonyms": [ "latent infection" ], "definition": "An infectious disease that arises from reactivation of a virus from a latent phase to a lytic phase." }, "child_count": 3, "reference_id": "MONDO:0100330" }, { "id": 25193, "label": "human betaherpesvirus 5 infectious disease", "isLeaf": true, "isRoot": false, "parents": [ 6834 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080827" ], "synonyms": [ "human cytomegalovirus infection" ], "definition": "A disease caused by infection with Human betaherpesvirus 5." }, "child_count": 0, "reference_id": "MONDO:0850289" } ], "roots": [ { "id": 7200, "label": "infectious disease" } ] }