{
  "id": 6809,
  "label": "preeclampsia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005081",
  "properties": {
    "xrefs": [
      "DOID:10591",
      "EFO:0000668",
      "GARD:0012924",
      "ICD10CM:O14",
      "ICD9:642.40",
      "ICD9:642.41",
      "ICD9:642.42",
      "ICD9:642.43",
      "ICD9:642.44",
      "MEDGEN:18608",
      "MESH:D011225",
      "MedDRA:10036485",
      "NCIT:C85021",
      "OMIMPS:189800",
      "Orphanet:275555",
      "SCTID:398254007",
      "UMLS:C0032914",
      "icd11.foundation:229121159"
    ],
    "synonyms": [
      "pre-eclampsia",
      "pre-eclamptic toxaemia",
      "pre-eclamptic toxemia",
      "preeclampsia",
      "preeclampsia/eclampsia",
      "pregnancy toxaemia",
      "proteinuric hypertension of pregnancy",
      "toxaemia of pregnancy",
      "toxemia of pregnancy"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 23534,
      "label": "toxemia of pregnancy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21571
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1638686",
          "NCIT:C34943",
          "UMLS:C4551893"
        ],
        "synonyms": [
          "toxemia of pregnancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A pregnancy induced hypertensive state that occurs after 20 weeks of gestation characterized by an increase in blood pressure, along with body swelling and proteinuria."
      },
      "child_count": 2,
      "reference_id": "MONDO:0045048"
    }
  ],
  "children": [
    {
      "id": 3325,
      "label": "mild pre-eclampsia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10590",
          "ICD9:642.41",
          "ICD9:642.42",
          "ICD9:642.43",
          "ICD9:642.44",
          "MEDGEN:542203",
          "SCTID:41114007",
          "UMLS:C0269658",
          "icd11.foundation:690705840"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001072"
    },
    {
      "id": 3837,
      "label": "severe pre-eclampsia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13129",
          "GARD:0022981",
          "ICD10CM:O14.1",
          "ICD9:642.50",
          "MEDGEN:574734",
          "NCIT:C112843",
          "UMLS:C0341950",
          "icd11.foundation:479404771"
        ],
        "synonyms": [
          "Preeclampsia with severe features",
          "severe preeclampsia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances."
      },
      "child_count": 1,
      "reference_id": "MONDO:0001641"
    },
    {
      "id": 13323,
      "label": "preeclampsia/eclampsia 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018390",
          "MEDGEN:322876",
          "OMIM:609402",
          "UMLS:C1836257"
        ],
        "synonyms": [
          "PEE2",
          "PREECLAMPSIA/eclampsia 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012264"
    },
    {
      "id": 13324,
      "label": "preeclampsia/eclampsia 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018391",
          "MEDGEN:322875",
          "OMIM:609403",
          "UMLS:C1836256"
        ],
        "synonyms": [
          "PEE3",
          "PREECLAMPSIA/eclampsia 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012265"
    },
    {
      "id": 13325,
      "label": "preeclampsia/eclampsia 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018392",
          "MEDGEN:322874",
          "MESH:C563724",
          "OMIM:609404",
          "UMLS:C1836255"
        ],
        "synonyms": [
          "Preeclampsia/eclampsia type 4",
          "STOX1 preeclampsia",
          "preeclampsia caused by mutation in STOX1",
          "preeclampsia/eclampsia 4",
          "PEE4",
          "PREECLAMPSIA/eclampsia 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any preeclampsia in which the cause of the disease is a mutation in the STOX1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012266"
    },
    {
      "id": 14831,
      "label": "preeclampsia/eclampsia 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018393",
          "MEDGEN:482918",
          "OMIM:614595",
          "UMLS:C3281288"
        ],
        "synonyms": [
          "CORIN preeclampsia",
          "Corin preeclampsia",
          "Preeclampsia/eclampsia type 5",
          "preeclampsia caused by mutation in CORIN",
          "preeclampsia caused by mutation in Corin",
          "preeclampsia/eclampsia 5",
          "PEE5",
          "PREECLAMPSIA/eclampsia 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any preeclampsia in which the cause of the disease is a mutation in the CORIN gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013817"
    },
    {
      "id": 24193,
      "label": "preeclampsia/eclampsia 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018389",
          "MEDGEN:1807479",
          "OMIM:189800",
          "UMLS:C5574918"
        ],
        "synonyms": [
          "toxaemia of pregnancy",
          "toxemia of pregnancy",
          "PEE1",
          "PREECLAMPSIA/eclampsia 1",
          "PREG1",
          "hemolysis, elevated liver enzymes, and low platelet count",
          "hypertension, pregnancy-induced"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0100467"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 23534,
      "label": "toxemia of pregnancy"
    }
  ]
}