{
  "id": 6729,
  "label": "breast adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004988",
  "properties": {
    "xrefs": [
      "DOID:3458",
      "EFO:0000304",
      "MEDGEN:167809",
      "NCIT:C5214",
      "UMLS:C0858252"
    ],
    "synonyms": [
      "adenocarcinoma of breast",
      "adenocarcinoma of the breast",
      "breast adenocarcinoma",
      "mammary adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 3053,
      "label": "integumentary system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060122"
        ],
        "synonyms": [
          "cancer of integumental system",
          "integumental system cancer",
          "malignant integumental system neoplasm",
          "malignant neoplasm of integumental system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the integumental system"
      },
      "child_count": 14,
      "reference_id": "MONDO:0000653"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6730,
      "label": "breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        8659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3459",
          "EFO:0000305",
          "HP:0003002",
          "MEDGEN:146260",
          "NCIT:C4872",
          "SCTID:254838004",
          "UMLS:C0678222"
        ],
        "synonyms": [
          "breast cancer",
          "breast cancer, NOS",
          "cancer of breast",
          "cancer of the breast",
          "cancer, breast",
          "breast carcinoma",
          "carcinoma of breast",
          "carcinoma of the breast",
          "mammary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the breast"
      },
      "child_count": 26,
      "reference_id": "MONDO:0004989"
    }
  ],
  "children": [
    {
      "id": 2991,
      "label": "breast lobular carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050938",
          "EFO:0008509",
          "ICDO:8520/3",
          "MEDGEN:64634",
          "NCIT:C3771",
          "SCTID:278054005",
          "UMLS:C0206692"
        ],
        "synonyms": [
          "carcinoma of lobule of mammary gland",
          "lobular adenocarcinoma",
          "lobular breast carcinoma",
          "lobular carcinoma",
          "lobular carcinoma of breast",
          "lobular carcinoma of the breast",
          "lobule of mammary gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000552"
    },
    {
      "id": 4699,
      "label": "mammary Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3443",
          "ICDO:8540/3",
          "MEDGEN:18263",
          "MESH:D010144",
          "NCIT:C47857",
          "UMLS:C0030185"
        ],
        "synonyms": [
          "Paget disease of the breast",
          "Paget's disease of breast",
          "Paget's disease of the breast",
          "breast Paget disease",
          "mammary Paget disease",
          "mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A malignant neoplasm in which there is infiltration of the skin overlying the breast by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It is almost always associated with an intraductal or invasive ductal carcinoma of the breast. The clinical features include focal skin reddening, and eczema. Retraction of the nipple may sometimes occur."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002648"
    },
    {
      "id": 4719,
      "label": "signet ring cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        6819,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3503",
          "MEDGEN:236816",
          "NCIT:C5175",
          "ONCOTREE:BRSRCC",
          "UMLS:C1335964"
        ],
        "synonyms": [
          "SRC breast carcinoma",
          "SRC carcinoma of breast",
          "SRC carcinoma of the breast",
          "breast signet ring cell carcinoma",
          "mammary signet Ring cell carcinoma",
          "primary SRC breast carcinoma",
          "primary SRC carcinoma of breast",
          "primary SRC carcinoma of the breast",
          "primary mammary signet Ring cell carcinoma",
          "primary signet Ring cell breast carcinoma",
          "primary signet Ring cell carcinoma of breast",
          "primary signet Ring cell carcinoma of the breast",
          "signet Ring cell breast carcinoma",
          "signet Ring cell carcinoma of breast",
          "signet Ring cell carcinoma of the breast",
          "breast carcinoma with signet ring",
          "breast signet ring cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive breast adenocarcinoma characterized by the presence of malignant epithelial cells with signet ring appearance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002671"
    },
    {
      "id": 4746,
      "label": "breast mucinous cystadenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        7469
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3609",
          "MEDGEN:267769",
          "NCIT:C40354",
          "UMLS:C1511318"
        ],
        "synonyms": [
          "breast mucinous cystadenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive breast adenocarcinoma characterized by the presence of tall columnar neoplastic cells that contain intracytoplasmic mucin. Grossly, cystic changes are identified."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002705"
    },
    {
      "id": 5073,
      "label": "mucoepidermoid breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5029,
        6729,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4679",
          "GARD:0023361",
          "MEDGEN:233721",
          "NCIT:C5166",
          "UMLS:C1334813"
        ],
        "synonyms": [
          "breast mucoepidermoid carcinoma",
          "mucoepidermoid breast carcinoma",
          "mucoepidermoid carcinoma of breast",
          "mucoepidermoid carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma of the breast characterized by pools of mucin and islands of malignant squamous cells. Mucoepidermoid carcinomas of the breast are extremely rare."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003087"
    },
    {
      "id": 5145,
      "label": "adenoid cystic breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6729,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4877",
          "EFO:1000071",
          "GARD:0023402",
          "MEDGEN:231031",
          "NCIT:C5130",
          "ONCOTREE:ACBC",
          "UMLS:C1332167"
        ],
        "synonyms": [
          "adenocystic breast carcinoma",
          "adenocystic carcinoma of breast",
          "adenocystic carcinoma of the breast",
          "adenoid cystic breast carcinoma",
          "adenoid cystic carcinoma of breast",
          "adenoid cystic carcinoma of the breast",
          "breast adenoid cystic carcinoma",
          "mammary adenocystic carcinoma",
          "mammary adenoid cystic carcinoma",
          "adenoid cystic breast cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An adenoid cystic carcinoma primarily involving the breast. Three morphologic patterns are seen: cribriform, trabecular, and solid. The prognosis is excellent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003185"
    },
    {
      "id": 5524,
      "label": "sebaceous breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        7803,
        8388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5760",
          "MEDGEN:276789",
          "NCIT:C40369",
          "UMLS:C1519207"
        ],
        "synonyms": [
          "breast sebaceous adenocarcinoma",
          "sebaceous adenocarcinoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A very rare breast adenocarcinoma with sebaceous differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003635"
    },
    {
      "id": 5794,
      "label": "oncocytic breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6585",
          "MEDGEN:309476",
          "NCIT:C40366",
          "UMLS:C1518574"
        ],
        "synonyms": [
          "oncocytic breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A rare breast adenocarcinoma characterized by the presence of neoplastic oncocytic cells. The oncocytic cells comprise more than 70 percent of the malignant cellular population."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003935"
    },
    {
      "id": 6229,
      "label": "breast malignant eccrine spiradenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6221,
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7983",
          "GARD:0027680",
          "MEDGEN:277329",
          "NCIT:C5180",
          "UMLS:C1334565"
        ],
        "synonyms": [
          "breast malignant spiradenoma",
          "malignant breast eccrine spiradenoma",
          "malignant eccrine spiradenoma of breast",
          "malignant eccrine spiradenoma of the breast",
          "malignant spiradenoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A rare tumor characterized by malignant transformation of an eccrine spiradenoma of the breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004420"
    },
    {
      "id": 7234,
      "label": "breast ductal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3007",
          "EFO:0006318",
          "MEDGEN:315942",
          "MESH:D018270",
          "NCIT:C4017",
          "UMLS:C1527349"
        ],
        "synonyms": [
          "duct adenocarcinoma",
          "duct carcinoma",
          "ductal adenocarcinoma",
          "ductal carcinoma",
          "breast ductal carcinoma",
          "ductal breast adenocarcinoma",
          "ductal breast carcinoma",
          "ductal carcinoma of breast",
          "ductal carcinoma of the breast",
          "mammary duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005590"
    },
    {
      "id": 7813,
      "label": "lobular breast carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4565,
        5172,
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000326",
          "ICD10CM:D05.0",
          "ICDO:8520/2",
          "MEDGEN:79007",
          "NCIT:C4018",
          "ONCOTREE:LCIS",
          "SCTID:109888004",
          "UMLS:C0279563"
        ],
        "synonyms": [
          "LCIS",
          "lobular Ca in situ of breast",
          "lobular Ca in situ of the breast",
          "lobular breast carcinoma in situ",
          "lobular carcinoma in situ",
          "lobular carcinoma in situ (LCIS)",
          "lobular carcinoma in situ of breast",
          "lobular carcinoma in situ of the breast",
          "lobular carcinoma in situ of the breast (LCIS)",
          "non-infiltrating lobular breast carcinoma",
          "non-infiltrating lobular carcinoma",
          "non-infiltrating lobular carcinoma of breast",
          "non-infiltrating lobular carcinoma of the breast",
          "non-invasive lobular breast carcinoma",
          "non-invasive lobular carcinoma of breast",
          "non-invasive lobular carcinoma of the breast",
          "breast lobular carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006270"
    },
    {
      "id": 7844,
      "label": "mixed lobular and ductal breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6729,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000382",
          "ICD9:174.8",
          "MEDGEN:1779609",
          "NCIT:C5160",
          "ONCOTREE:MDLC",
          "SCTID:444604002",
          "UMLS:C5441546"
        ],
        "synonyms": [
          "ductal and lobular carcinoma",
          "mixed ductal and lobular breast carcinoma",
          "mixed ductal and lobular carcinoma of breast",
          "mixed ductal and lobular carcinoma of the breast",
          "mixed lobular and ductal breast carcinoma",
          "mixed lobular and ductal carcinoma",
          "mixed lobular and ductal carcinoma of breast",
          "mixed lobular and ductal carcinoma of the breast",
          "breast mixed ductal and lobular carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast carcinoma characterized by the presence of a lobular and a ductal component. The ductal component comprises less than 50 percent of the tumor."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006306"
    },
    {
      "id": 8252,
      "label": "inflammatory breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6263",
          "EFO:1000984",
          "GARD:0006784",
          "ICDO:8530/3",
          "MEDGEN:75841",
          "MESH:D058922",
          "MedDRA:10006205",
          "NCIT:C4001",
          "ONCOTREE:IBC",
          "Orphanet:694963",
          "SCTID:254840009",
          "UMLS:C0278601"
        ],
        "synonyms": [
          "inflammatory breast cancer",
          "inflammatory breast carcinoma",
          "inflammatory carcinoma of breast",
          "inflammatory carcinoma of the breast",
          "mastitis Carcinomatosa",
          "mastitis carcinomatosa",
          "IBC",
          "breast cancer, inflammatory"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006804"
    }
  ],
  "roots": [
    {
      "id": 3053,
      "label": "integumentary system cancer"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6730,
      "label": "breast carcinoma"
    }
  ]
}