{
  "id": 6214,
  "label": "Barrett adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004405",
  "properties": {
    "xrefs": [
      "DOID:7941",
      "EFO:1001939",
      "GARD:0023984",
      "MEDGEN:272350",
      "NCIT:C7027",
      "SCTID:721617001",
      "UMLS:C1332460",
      "icd11.foundation:1934528268"
    ],
    "synonyms": [
      "Barrett adenocarcinoma",
      "Barrett's adenocarcinoma",
      "adenocarcinoma arising in Barrett's mucosa"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An adenocarcinoma arising from Barrett metaplastic epithelium in the esophagus. There is evidence supporting the idea that the Barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy. Adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. In terms of grading, they are well or moderately differentiated adenocarcinomas. -- 2002"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6762,
      "label": "esophageal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4914",
          "EFO:0000478",
          "GARD:0016927",
          "MEDGEN:124636",
          "NCIT:C4025",
          "ONCOTREE:ESCA",
          "Orphanet:99976",
          "SCTID:276803003",
          "UMLS:C0279628",
          "icd11.foundation:829915640"
        ],
        "synonyms": [
          "adenocarcinoma - esophagus",
          "adenocarcinoma - oesophagus",
          "adenocarcinoma of esophagus",
          "adenocarcinoma of oesophagus",
          "adenocarcinoma of the esophagus",
          "adenocarcinoma of the oesophagus",
          "esophageal adenocarcinoma",
          "esophagus adenocarcinoma",
          "oesophageal adenocarcinoma",
          "oesophagus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005028"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6762,
      "label": "esophageal adenocarcinoma"
    }
  ]
}