{
  "id": 5960,
  "label": "anal verrucous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004131",
  "properties": {
    "xrefs": [
      "DOID:7175",
      "GARD:0023840",
      "MEDGEN:231066",
      "NCIT:C7470",
      "UMLS:C1332278"
    ],
    "synonyms": [
      "anal Buschke-Lowenstein tumor",
      "anal Buschke-Lowenstein tumour",
      "anal giant (malignant) condyloma",
      "anal verrucous carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A large, well differentiated squamous cell carcinoma with a cauliflower-like appearance, characterized by the presence of an exophytic and endophytic growth pattern. Morphologically, there is papillomatosis and acanthosis present, however cytologically the neoplastic squamous cells have a benign appearance. Dysplastic changes are minimal. It does not respond to conservative treatment and it is regarded by many authors as an intermediate lesion between condyloma acuminatum and squamous cell carcinoma."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7659,
      "label": "anal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5158,
        18545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5525",
          "EFO:1000081",
          "GARD:0024286",
          "MEDGEN:237257",
          "NCIT:C9161",
          "ONCOTREE:ANSC",
          "UMLS:C1412036"
        ],
        "synonyms": [
          "anal squamous cell cancer",
          "anal squamous cell carcinoma",
          "anus squamous cell carcinoma",
          "epidermoid anal carcinoma",
          "epidermoid carcinoma of anus",
          "epidermoid carcinoma of the anus",
          "squamous cell anal carcinoma",
          "squamous cell carcinoma - anus",
          "squamous cell carcinoma of anus",
          "squamous cell carcinoma of the anus",
          "ANSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006082"
    },
    {
      "id": 21745,
      "label": "Buschke Lowenstein tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        7283,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009663",
          "MEDGEN:473018",
          "MESH:D062688",
          "NCIT:C6371",
          "SCTID:402910001",
          "UMLS:C0276264"
        ],
        "synonyms": [
          "Buschke Lowenstein tumor",
          "giant condyloma acuminatum involving the prepuce and glans penis",
          "giant condyloma of Buschke and Lowenstein",
          "Buschke-Lowenstein tumor",
          "Buschke-Lowenstein tumour",
          "GCBL",
          "Giant condyloma Acuminatum",
          "Giant condyloma Acuminatums",
          "Giant condyloma of Buschke and Lowenstein",
          "Lowenstein tumor, Buschke",
          "anogenital type verrucous carcinoma",
          "condyloma Acuminatum, Giant",
          "condyloma Acuminatums, Giant",
          "tumor, Buschke Lowenstein",
          "tumor, Buschke-Lowenstein"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A verrucous carcinoma of the skin or mucosa that occurs in the anogenital region."
      },
      "child_count": 3,
      "reference_id": "MONDO:0027026"
    },
    {
      "id": 23208,
      "label": "digestive system infectious disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "NCIT:C35503",
          "SCTID:715852004"
        ],
        "synonyms": [
          "digestive system infection",
          "gastrointestinal infection",
          "gastrointestinal system infection",
          "infection of gastrointestinal tract"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A viral, bacterial, fungal, or parasitic infectious process that affects the digestive system."
      },
      "child_count": 44,
      "reference_id": "MONDO:0043424"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7659,
      "label": "anal squamous cell carcinoma"
    },
    {
      "id": 21745,
      "label": "Buschke Lowenstein tumor"
    },
    {
      "id": 23208,
      "label": "digestive system infectious disorder"
    }
  ]
}