{
  "id": 5345,
  "label": "skin pilomatrix carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003414",
  "properties": {
    "xrefs": [
      "DOID:5376",
      "GARD:0022042",
      "ICDO:8110/3",
      "MEDGEN:108439",
      "NCIT:C4114",
      "Orphanet:499182",
      "SCTID:307610008",
      "UMLS:C0585475"
    ],
    "synonyms": [
      "Pilomatrical carcinoma",
      "Trichomatrical carcinoma",
      "calcified epithelial carcinoma of Malherbe",
      "calcifying epitheliocarcinoma",
      "invasive pilomatrixoma",
      "malignant pilomatricoma",
      "matrical carcinoma",
      "pilomatrix carcinoma",
      "pilomatrix carcinoma of skin",
      "pilomatrix carcinoma of the skin",
      "pilomatrix skin carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 8398,
      "label": "skin appendage carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4406,
        4707
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001183",
          "ICDO:8390/3",
          "MEDGEN:60209",
          "MESH:D018280",
          "MedDRA:10040798",
          "NCIT:C3775",
          "ONCOTREE:SKAC",
          "UMLS:C0206697"
        ],
        "synonyms": [
          "adnexal carcinoma",
          "carcinoma of adnexa",
          "carcinoma of cutaneous appendage",
          "carcinoma of skin appendage",
          "carcinoma, adnexal, malignant",
          "cutaneous appendage carcinoma",
          "skin appendage carcinoma",
          "skin adnexal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006973"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 8398,
      "label": "skin appendage carcinoma"
    }
  ]
}