{
  "id": 5261,
  "label": "hereditary Wilms tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003321",
  "properties": {
    "xrefs": [
      "DOID:5183",
      "GARD:0023447",
      "MEDGEN:146190",
      "NCIT:C8496",
      "OMIMPS:194070",
      "UMLS:C0677779"
    ],
    "synonyms": [
      "familial Wilms tumor",
      "familial Wilms tumour",
      "familial Wilms' tumor",
      "familial Wilms' tumour",
      "hereditary Wilms tumor",
      "hereditary kidney adenosarcoma",
      "hereditary nephroblastoma",
      "hereditary renal adenosarcoma",
      "WT1"
    ],
    "definition": "Familial embryonal neoplasm derived from nephrogenic blastemal cells. Several lines of differentiation, including blastemal, stromal and epithelial, are usually expressed. Comprises approximately 1% of Wilms tumors. (AFIP fascicle version 2.0)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 7641,
      "label": "Wilms tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7212,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027737",
          "MEDGEN:10221",
          "MESH:D009396",
          "NCIT:C3267",
          "UMLS:C0027708"
        ],
        "synonyms": [
          "Wilms tumor",
          "Wilms' tumor",
          "Wilms' tumour",
          "Wilms tumor (nephroblastoma)",
          "Wilms tumour (nephroblastoma)"
        ],
        "definition": "An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006058"
    }
  ],
  "children": [
    {
      "id": 9954,
      "label": "Wilms tumor 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015124",
          "OMIM:194070"
        ],
        "synonyms": [
          "Wilms' tumor",
          "Wilms' tumour",
          "renal Wilms tumor",
          "renal Wilms tumour",
          "WT1-related Wilms tumor predisposition",
          "Wilms tumor 1",
          "Wilms tumor type 1",
          "Wilms tumor, autosomal dominant, somatic mutation",
          "Wilms tumor, somatic",
          "Wilms tumor, type 1, autosomal dominant, somatic mutation",
          "Wilms tumour type 1",
          "WT1",
          "nephroblastoma"
        ],
        "definition": "An autosomal disorder due to pathogenic variants in the WT1 gene leading to an increased risk Wilms tumor and genitourinary abnormalities incorporating Denys-Drash syndrome and Frasier syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008679"
    },
    {
      "id": 9955,
      "label": "Wilms tumor 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008559",
          "MEDGEN:854562",
          "MESH:C536853",
          "OMIM:194071",
          "UMLS:C3887743"
        ],
        "synonyms": [
          "Wilms tumor 2",
          "Wilms tumor 2, autosomal dominant, somatic mutation",
          "Wilms tumor type 2",
          "Wilms tumour 2, autosomal dominant, somatic mutation",
          "Wilms tumour type 2",
          "FWT2",
          "WT2",
          "familial Wilms tumor 2",
          "familial Wilms tumour 2"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008680"
    },
    {
      "id": 9958,
      "label": "Wilms tumor 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015125",
          "MEDGEN:349770",
          "MESH:C565991",
          "OMIM:194090",
          "UMLS:C1860265"
        ],
        "synonyms": [
          "Wilms tumor 3",
          "Wilms tumor, type 3",
          "WT3"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008683"
    },
    {
      "id": 12182,
      "label": "Wilms tumor 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015328",
          "MEDGEN:318623",
          "MESH:C563336",
          "OMIM:601363",
          "UMLS:C1832426"
        ],
        "synonyms": [
          "Wilms tumor 4",
          "Wilms tumor type 4",
          "Wilms tumor, type 4",
          "Wilms tumour type 4",
          "WT4",
          "familial Wilms tumor 1",
          "familial Wilms tumour 1"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011056"
    },
    {
      "id": 12236,
      "label": "Wilms tumor 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015336",
          "MEDGEN:316905",
          "MESH:C536707",
          "OMIM:601583",
          "UMLS:C1832099"
        ],
        "synonyms": [
          "Wilms tumor 5",
          "Wilms tumor susceptibility-5, autosomal dominant, somatic mutation",
          "Wilms tumor type 5",
          "Wilms tumour susceptibility-5, autosomal dominant, somatic mutation",
          "Wilms tumour type 5",
          "WT5",
          "Wilms tumor and radial bilateral aplasia",
          "Wilms tumor, susceptibility to",
          "Wilms tumour and radial bilateral aplasia",
          "bilateral radial aplasia with Wilms tumor",
          "bilateral radial aplasia with Wilms tumour"
        ],
        "definition": "Any Wilms tumor in which the cause of the disease is a mutation in the POU6F2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011112"
    },
    {
      "id": 15768,
      "label": "Wilms tumor 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016162",
          "MEDGEN:855962",
          "OMIM:616806",
          "UMLS:C3891301"
        ],
        "synonyms": [
          "WT6",
          "Wilms tumor 6",
          "Wilms tumor 6; WT6",
          "Wilms tumor type 6",
          "Wilms tumour 6; WT6",
          "Wilms tumour type 6",
          "Wilms tumor 6, susceptibility to",
          "Wilms tumour 6, susceptibility to"
        ],
        "definition": "Any Wilms tumor in which the cause of the disease is a mutation in the REST gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014779"
    },
    {
      "id": 26329,
      "label": "Wilms tumor 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028125",
          "OMIM:621332"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0979876"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 7641,
      "label": "Wilms tumor"
    }
  ]
}