{
  "id": 4718,
  "label": "ampulla of vater adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002670",
  "properties": {
    "xrefs": [
      "DOID:3502",
      "EFO:0008490",
      "GARD:0023208",
      "MEDGEN:231054",
      "NCIT:C6650",
      "UMLS:C1332243",
      "icd11.foundation:1601321941"
    ],
    "synonyms": [
      "adenocarcinoma of ampulla of Vater",
      "ampulla of Vater adenocarcinoma",
      "ampullary adenocarcinoma",
      "hepatopancreatic ampulla adenocarcinoma",
      "invasive adenocarcinoma of the ampullary region"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the hepatopancreatic ampulla"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5152
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3495",
          "GARD:0023205",
          "MEDGEN:124642",
          "NCIT:C7975",
          "UMLS:C0279659"
        ],
        "synonyms": [
          "adenocarcinoma of extrahepatic bile duct",
          "adenocarcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the extrahepatic bile duct"
      },
      "child_count": 14,
      "reference_id": "MONDO:0002665"
    },
    {
      "id": 7742,
      "label": "duodenal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5157,
        20511
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10816",
          "EFO:1000223",
          "GARD:0024322",
          "MEDGEN:82985",
          "NCIT:C7889",
          "ONCOTREE:DA",
          "SCTID:408644002",
          "UMLS:C0278804",
          "icd11.foundation:1182663077"
        ],
        "synonyms": [
          "adenocarcinoma of duodenum",
          "adenocarcinoma of the duodenum",
          "duodenal adenocarcinoma",
          "duodenum adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the duodenum."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006186"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3189,
        5076,
        20511
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4932",
          "EFO:1000079",
          "GARD:0021237",
          "MEDGEN:120461",
          "MedDRA:10048853",
          "NCIT:C3908",
          "ONCOTREE:AMPCA",
          "Orphanet:300557",
          "SCTID:254609000",
          "UMLS:C0262401",
          "icd11.foundation:267067189"
        ],
        "synonyms": [
          "Ampulloma",
          "ampulla of Vater cancer",
          "ampulla of Vater carcinoma",
          "ampullary cancer",
          "ampullary carcinoma",
          "carcinoma of ampulla of vater",
          "carcinoma of hepatopancreatic ampulla",
          "hepatopancreatic ampulla carcinoma",
          "AMPCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017590"
    }
  ],
  "children": [
    {
      "id": 4717,
      "label": "ampullary signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4713,
        4718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3501",
          "GARD:0023207",
          "MEDGEN:231057",
          "NCIT:C6656",
          "UMLS:C1332249"
        ],
        "synonyms": [
          "ampulla of Vater signet Ring cell carcinoma",
          "ampullary signet Ring cell carcinoma",
          "ampullary signet ring cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of mucin-containing signet-ring cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002669"
    },
    {
      "id": 4772,
      "label": "ampulla of vater mucinous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4718,
        4775
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3693",
          "GARD:0023225",
          "MEDGEN:233973",
          "NCIT:C27416",
          "UMLS:C1332248"
        ],
        "synonyms": [
          "ampulla of Vater mucinous adenocarcinoma",
          "hepatopancreatic ampulla mucinous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with glandular differentiation arising from the ampulla of Vater. Morphologically, it is characterized by the presence of mucoid stroma formation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002736"
    },
    {
      "id": 5320,
      "label": "ampulla of vater clear cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4718,
        5917
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5308",
          "GARD:0023494",
          "MEDGEN:233972",
          "NCIT:C27414",
          "UMLS:C1332246"
        ],
        "synonyms": [
          "ampulla of Vater clear cell adenocarcinoma",
          "hepatopancreatic ampulla clear cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with glandular differentiation arising from the ampulla of Vater. Morphologically, it is characterized by the presence of glycogen-rich cells with hyperchromatic nuclei."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003388"
    },
    {
      "id": 6271,
      "label": "periampullary adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8110",
          "GARD:0024020",
          "MEDGEN:233847",
          "NCIT:C27322",
          "UMLS:C1335377"
        ],
        "synonyms": [
          "periampullary adenocarcinoma",
          "periampullary cancer",
          "periampullary region of duodenum adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the periampullary region."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004465"
    }
  ],
  "roots": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma"
    },
    {
      "id": 7742,
      "label": "duodenal adenocarcinoma"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater"
    }
  ]
}