{
  "id": 4598,
  "label": "skin squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002529",
  "properties": {
    "xrefs": [
      "DOID:3151",
      "MEDGEN:107512",
      "NCIT:C4819",
      "ONCOTREE:CSCC",
      "SCTID:254651007",
      "UMLS:C0553723",
      "icd11.foundation:1448983042"
    ],
    "synonyms": [
      "cutaneous squamous cell carcinoma",
      "epidermoid carcinoma of skin",
      "epidermoid carcinoma of the skin",
      "epidermoid skin carcinoma",
      "skin squamous cell cancer",
      "skin squamous cell carcinoma",
      "squamous cell carcinoma - skin",
      "squamous cell carcinoma of skin",
      "squamous cell carcinoma of the skin",
      "squamous cell skin carcinoma",
      "zone of skin squamous cell carcinoma",
      "CSCC"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4707,
      "label": "skin carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4907,
        6734,
        20690
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3451",
          "EFO:0009259",
          "MEDGEN:195945",
          "NCIT:C4914",
          "UMLS:C0699893"
        ],
        "synonyms": [
          "carcinoma of skin",
          "carcinoma of the skin",
          "carcinoma of zone of skin",
          "non-melanoma cancer of skin",
          "non-melanoma cancer of the skin",
          "non-melanoma skin cancer",
          "nonmelanoma skin cancer",
          "skin cancer, non-melanoma",
          "skin carcinoma",
          "zone of skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the zone of skin"
      },
      "child_count": 39,
      "reference_id": "MONDO:0002656"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 3684,
      "label": "anal margin squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        4946,
        7659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12239",
          "GARD:0022948",
          "ICD10CM:C44.520",
          "ICD9:173.5",
          "MEDGEN:278071",
          "NCIT:C6925",
          "SCTID:255084004",
          "UMLS:C1412037"
        ],
        "synonyms": [
          "anal margin squamous cell carcinoma",
          "perianal skin squamous cell carcinoma",
          "squamous cell carcinoma of anal margin",
          "squamous cell carcinoma of the anal margin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the perianal skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001470"
    },
    {
      "id": 4799,
      "label": "plantar verrucous skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3751",
          "MEDGEN:578859",
          "NCIT:C6811",
          "UMLS:C0349657"
        ],
        "synonyms": [
          "plantar part of pes verrucous carcinoma",
          "plantar verrucous carcinoma of skin",
          "plantar verrucous carcinoma of the skin",
          "plantar verrucous skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A verrucous carcinoma that involves the plantar part of pes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002765"
    },
    {
      "id": 5413,
      "label": "sarcomatoid squamous cell skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5536",
          "MEDGEN:87611",
          "NCIT:C4666",
          "SCTID:254653005",
          "UMLS:C0349656"
        ],
        "synonyms": [
          "spindle cell squamous carcinoma of skin",
          "spindle cell squamous carcinoma of the skin",
          "spindle cell squamous cell carcinoma",
          "spindle cell (sarcomatoid) squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the skin with a prominent spindle cell component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003499"
    },
    {
      "id": 5926,
      "label": "skin basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        5405,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7049",
          "MEDGEN:233446",
          "NCIT:C27543",
          "UMLS:C1335973"
        ],
        "synonyms": [
          "basaloid skin squamous cell carcinoma",
          "skin basaloid carcinoma",
          "skin basaloid squamous cell carcinoma",
          "zone of skin basaloid squamous cell carcinoma",
          "basaloid squamous cell skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A basaloid squamous cell carcinoma that involves the zone of skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004091"
    },
    {
      "id": 6132,
      "label": "acantholytic squamous cell skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7643",
          "MEDGEN:91065",
          "NCIT:C4460",
          "SCTID:254654004",
          "UMLS:C0345979"
        ],
        "synonyms": [
          "acantholytic squamous cell carcinoma of the skin",
          "acantholytic squamous cell skin carcinoma",
          "acantholytic squamous cell carcinoma of skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004316"
    },
    {
      "id": 6275,
      "label": "pseudovascular skin squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8122",
          "MEDGEN:233447",
          "NCIT:C27542",
          "UMLS:C1335974"
        ],
        "synonyms": [
          "pseudovascular skin squamous cell carcinoma",
          "skin pseudovascular squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004469"
    },
    {
      "id": 6324,
      "label": "clear cell squamous cell skin carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        6786
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8288",
          "MEDGEN:91064",
          "NCIT:C4459",
          "SCTID:254652000",
          "UMLS:C0345978"
        ],
        "synonyms": [
          "clear cell squamous cell carcinoma of skin",
          "clear cell squamous cell carcinoma of the skin",
          "clear cell squamous cell skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma of the skin with a prominent clear cell component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004523"
    },
    {
      "id": 20161,
      "label": "skin squamous cell carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4598,
        6427,
        6473
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:378389",
          "NCIT:C2906",
          "UMLS:C2314897"
        ],
        "synonyms": [
          "intraepidermal squamous cell carcinoma",
          "skin squamous cell cancer in situ",
          "skin squamous cell carcinoma in situ",
          "squamous cell carcinoma in situ of skin",
          "squamous cell carcinoma in situ of the skin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Intraepidermal squamous cell carcinoma, confined to the epidermis. There is no evidence of invasion."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020760"
    },
    {
      "id": 23673,
      "label": "skin adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4598,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:313707",
          "NCIT:C54250",
          "UMLS:C1710103"
        ],
        "synonyms": [
          "skin adenosquamous cancer",
          "skin adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An uncommon carcinoma that arises from the skin. It is characterized by the presence of malignant glandular and malignant squamous cellular components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0056818"
    }
  ],
  "roots": [
    {
      "id": 4707,
      "label": "skin carcinoma"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}