{
  "id": 4596,
  "label": "keratoacanthoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002527",
  "properties": {
    "xrefs": [
      "DOID:3149",
      "ICDO:8071/1",
      "MEDGEN:5954",
      "MESH:D007636",
      "NCIT:C3146",
      "SCTID:254662007",
      "UMLS:C0022572",
      "icd11.foundation:516478127"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A dome-shaped, rapidly growing skin lesion composed of well differentiated squamous cells. It represents a proliferation of the infundibular epithelium of the hair follicle and its morphologic distinction from a well differentiated carcinoma may be difficult or impossible. Keratoacanthomas affect males more frequently than females and the majority tend to regress spontaneously. It has been suggested that keratoacanthoma represents a distinct subtype of squamous cell carcinoma of the skin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 20690,
      "label": "epithelial skin neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:91063",
          "NCIT:C7342",
          "UMLS:C0345976"
        ],
        "synonyms": [
          "epithelial skin neoplasm",
          "epithelial skin tumor",
          "epithelial skin tumour",
          "skin epithelium neoplasm",
          "skin epithelium tumor",
          "skin epithelium tumour",
          "zone of skin epithelial neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A epithelial neoplasm that involves the zone of skin."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021634"
    }
  ],
  "children": [
    {
      "id": 18511,
      "label": "generalized eruptive keratoacanthoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4596
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021736",
          "MEDGEN:577226",
          "Orphanet:411777",
          "SCTID:254664008",
          "UMLS:C0345985"
        ],
        "synonyms": [
          "GEKA",
          "Grzybowski syndrome",
          "generalised eruptive keratoacanthomas of Grzybowski",
          "generalized eruptive keratoacanthomas of Grzybowski"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Generalized eruptive keratoacanthoma (GEKA) is rare variant of keratoacanthoma (KA) that affects the skin and mucous membranes and which is characterized by a sudden generalized eruption of severely pruritic, hundreds to thousands of small follicular papules, often with a central keratotic plug."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018471"
    },
    {
      "id": 18787,
      "label": "familial keratoacanthoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4596,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018693",
          "MEDGEN:1843863",
          "Orphanet:493",
          "SCTID:716774008",
          "UMLS:C5848325"
        ],
        "synonyms": [
          "hereditary keratoacanthoma",
          "multiple keratoacanthoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Multiple familial keratoacanthoma (KA) of Witten and Zak is a rare a rare inherited skin cancer syndrome and is characterized by the coexistence of features characteristic of both multiple KA, Ferguson Smith type and generalized eruptive keratoacanthoma, such as multiple small miliary-type lesions, larger self-healing lesions, and nodulo-ulcerative lesions. Lesions do not have a predilection for the mucosal surfaces. Transmission is autosomal dominant."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018851"
    }
  ],
  "roots": [
    {
      "id": 20690,
      "label": "epithelial skin neoplasm"
    }
  ]
}