{
  "id": 4561,
  "label": "ovarian neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002481",
  "properties": {
    "xrefs": [
      "DOID:3002",
      "GARD:0023145",
      "MEDGEN:277459",
      "NCIT:C5237",
      "UMLS:C1335172"
    ],
    "synonyms": [
      "neuroendocrine neoplasm of ovary",
      "neuroendocrine neoplasm of the ovary",
      "neuroendocrine tumour of ovary",
      "ovarian neuroendocrine neoplasm",
      "ovary NET",
      "ovary neuroendocrine neoplasm",
      "ovary neuroendocrine tumor",
      "ovary neuroendocrine tumor, well differentiated, low or intermediate grade",
      "ovary neuroendocrine tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 9481,
      "label": "ovarian cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3637,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2394",
          "ICD10CM:C56",
          "ICD9:183.0",
          "MEDGEN:216027",
          "MESH:D010051",
          "NCIT:C7431",
          "OMIM:167000",
          "Orphanet:213500",
          "SCTID:363443007",
          "UMLS:C1140680",
          "icd11.foundation:685124533"
        ],
        "synonyms": [
          "ovarian neoplasm",
          "ovary neoplasm",
          "tumor of the ovary",
          "tumour of the ovary",
          "cancer of ovary",
          "cancer of the ovary",
          "malignant neoplasm of ovary",
          "malignant neoplasm of the ovary",
          "malignant ovarian neoplasm",
          "malignant ovarian tumor",
          "malignant ovarian tumour",
          "malignant ovary neoplasm",
          "malignant tumor of ovary",
          "malignant tumor of the ovary",
          "malignant tumour of ovary",
          "malignant tumour of the ovary",
          "ovarian cancer",
          "ovarian cancer, somatic",
          "ovarian malignant tumor",
          "ovarian malignant tumour",
          "ovary cancer",
          "ovarian cancer, epithelial",
          "primary ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
      },
      "child_count": 22,
      "reference_id": "MONDO:0008170"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:170",
          "ICD9:194.9",
          "MEDGEN:56319",
          "MESH:D004701",
          "NCIT:C3575",
          "UMLS:C0153658"
        ],
        "synonyms": [
          "endocrine neoplasm",
          "Endocrine tumour",
          "cancer of endocrine gland",
          "endocrine cancer",
          "endocrine gland cancer",
          "endocrine neoplasm, malignant",
          "malignant endocrine gland neoplasm",
          "malignant endocrine gland tumor",
          "malignant endocrine gland tumour",
          "malignant endocrine neoplasm",
          "malignant endocrine tumor",
          "malignant endocrine tumour",
          "malignant neoplasm of endocrine gland",
          "malignant neoplasm of the endocrine gland",
          "malignant tumor of endocrine gland",
          "malignant tumor of the endocrine gland",
          "malignant tumour of the endocrine gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0021069"
    }
  ],
  "children": [
    {
      "id": 5039,
      "label": "ovarian large-cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4561,
        6787,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4555",
          "GARD:0023345",
          "MEDGEN:233809",
          "NCIT:C5238",
          "UMLS:C1335174"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of ovary",
          "large cell neuroendocrine carcinoma of the ovary",
          "large-cell neuroendocrine carcinoma of ovary",
          "large-cell neuroendocrine carcinoma of the ovary",
          "non-small-cell type neuroendocrine carcinoma of ovary",
          "non-small-cell type neuroendocrine carcinoma of the ovary",
          "ovarian large cell NEC",
          "ovarian large cell neuroendocrine carcinoma",
          "ovarian non-small-cell type neuroendocrine carcinoma",
          "ovary large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of large malignant cells exhibiting neuroendocrine differentiation. The prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003049"
    },
    {
      "id": 5672,
      "label": "ovarian small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2894,
        4561,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6179",
          "EFO:1000431",
          "GARD:0010411",
          "MEDGEN:389177",
          "NCIT:C27390",
          "ONCOTREE:SCCO",
          "Orphanet:370396",
          "UMLS:C2212006"
        ],
        "synonyms": [
          "SCCO",
          "ovarian small cell NEC",
          "ovarian small cell cancer",
          "ovarian small cell carcinoma",
          "ovarian small cell neuroendocrine carcinoma",
          "ovary small cell carcinoma",
          "small cell carcinoma of ovary",
          "small cell carcinoma of the ovary",
          "small cell ovarian carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of small malignant cells. It includes small cell carcinoma, hypercalcemic type and small cell carcinoma, pulmonary type."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003795"
    }
  ],
  "roots": [
    {
      "id": 9481,
      "label": "ovarian cancer"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm"
    }
  ]
}