{
  "id": 4516,
  "label": "protozoa infectious disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002428",
  "properties": {
    "xrefs": [
      "DOID:2789",
      "ICD10CM:B50-B64",
      "MESH:D011528",
      "NCIT:C34953"
    ],
    "synonyms": [
      "protozoal infection",
      "Mastigophora infectious disease",
      "sarcomastigophora infectious disease",
      "parasitic protozoa infectious disease"
    ],
    "definition": "An infection that is caused by protozoans."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 15,
  "parents": [
    {
      "id": 6859,
      "label": "parasitic infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1398",
          "EFO:0001067",
          "ICD9:129",
          "ICD9:134.8",
          "ICD9:134.9",
          "ICD9:136.4",
          "ICD9:136.8",
          "ICD9:136.9",
          "ICD9:376.13",
          "MEDGEN:45325",
          "MESH:D010272",
          "NCIT:C27864",
          "SCTID:17322007",
          "UMLS:C0030499"
        ],
        "synonyms": [
          "disease caused by parasite",
          "parasitic disease",
          "parasitic infection",
          "ectoparasitic disease",
          "parasitemia",
          "disease, parasitic",
          "diseases, parasitic",
          "infestation",
          "parasite infestation",
          "parasitism",
          "parasitosis"
        ],
        "definition": "A successful invasion of a host by an organism that uses the host for food and shelter."
      },
      "child_count": 17,
      "reference_id": "MONDO:0005135"
    }
  ],
  "children": [
    {
      "id": 2818,
      "label": "primary amebic meningoencephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        19721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050242",
          "GARD:0009554",
          "ICD10CM:B60.2",
          "MEDGEN:81253",
          "MESH:C535275",
          "SCTID:721816008",
          "UMLS:C0300934"
        ],
        "synonyms": [
          "Naegleria fowleri infection",
          "infections, Naegleria fowleri"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A infectious disease involving the Naegleria fowleri."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000290"
    },
    {
      "id": 2819,
      "label": "granulomatous amebic encephalitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        19721,
        20742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050246",
          "GARD:0012651",
          "ICD9:323.2",
          "MEDGEN:572559",
          "SCTID:230187000",
          "UMLS:C0338428"
        ],
        "synonyms": [
          "Acanthamoeba encephalitis",
          "Acanthamoeba granulomatous encephalitis",
          "granulomatous amebic encephalitis due to Acanthamoeba"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Granulomatous amebic encephalitis is a life-threatening infection of the brain caused by the free-living amoebae Acanthamoeba spp., Balamuthia mandrillaris and Sappinia pedata. Acanthamoeba species, are commonly found in lakes, swimming pools, tap water, and heating and air conditioning units. The disease affects immunocompromised people and is very serious. Symptoms include mental status changes, loss of coordination, fever, muscular weakness or partial paralysis affecting one side of the body, double vision, sensitivity to light and other neurologic problems. The diagnosis is difficult and is often made at advanced stages. Tests useful in the diagnosis include brain scans, biopsies, or spinal taps and in disseminated disease, biopsy of the involved sites and testing by the laboratory experts. Early diagnosis is important for the prognosis. No single drug is effective; hence multiple antibiotics are needed for successful treatment. A combination of surgical and medical interventions involving multiple specialty experts is required to prevent death and morbidity in survivors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000291"
    },
    {
      "id": 3209,
      "label": "trypanosomiasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10113",
          "ICD10CM:B56",
          "ICD9:086",
          "ICD9:086.9",
          "MEDGEN:52872",
          "MESH:D014352",
          "NANDO:2200774",
          "SCTID:78940002",
          "UMLS:C0041227"
        ],
        "synonyms": [
          "Trypanosoma caused disease or disorder",
          "Trypanosoma disease or disorder",
          "Trypanosoma infectious disease",
          "Trypanosomiases"
        ],
        "definition": "Infection with protozoa of the genus trypanosoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000940"
    },
    {
      "id": 3353,
      "label": "giardiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        21309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10718",
          "ICD10CM:A07.1",
          "ICD9:007.1",
          "MEDGEN:42213",
          "MESH:D005873",
          "SCTID:10679007",
          "UMLS:C0017536",
          "icd11.foundation:433310499"
        ],
        "synonyms": [
          "Giardia infection",
          "Giardia",
          "Giardiases",
          "Lambliases",
          "infections, Giardia",
          "lambliasis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An infection of the small intestine caused by the flagellated protozoan giardia lamblia. It is spread via contaminated food and water and by direct person-to-person contact."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001103"
    },
    {
      "id": 4122,
      "label": "protozoal dysentery",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3725,
        4516,
        21309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14397",
          "ICD9:007.8",
          "MEDGEN:1843396",
          "UMLS:C2142761"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A dysentery that involves protozoan infection."
      },
      "child_count": 3,
      "reference_id": "MONDO:0001955"
    },
    {
      "id": 4283,
      "label": "trichomoniasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1947",
          "ICD10CM:A59",
          "ICD10WHO:A59",
          "ICD9:131",
          "ICD9:131.8",
          "ICD9:131.9",
          "MEDGEN:52838",
          "MESH:D014245",
          "NCIT:C35720",
          "SCTID:56335008",
          "UMLS:C0040921",
          "icd11.foundation:1220564554"
        ],
        "synonyms": [
          "Trichomonas infection",
          "infections, Trichomonas"
        ],
        "definition": "An infection that is caused by Trichomonas."
      },
      "child_count": 5,
      "reference_id": "MONDO:0002154"
    },
    {
      "id": 6860,
      "label": "malaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4516,
        23347,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12365",
          "EFO:0001068",
          "GARD:0006961",
          "ICD10CM:B53",
          "ICD9:084",
          "ICD9:084.6",
          "MEDGEN:7443",
          "MESH:D008288",
          "MedDRA:10025487",
          "NCIT:C34797",
          "NORD:1395",
          "Orphanet:673",
          "SCTID:61462000",
          "UMLS:C0024530",
          "icd11.foundation:1439886552"
        ],
        "synonyms": [
          "plasmodiosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly.Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired."
      },
      "child_count": 21,
      "reference_id": "MONDO:0005136"
    },
    {
      "id": 7268,
      "label": "Acanthamoeba keratitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        20742,
        21277,
        21348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007126",
          "GARD:0009285",
          "ICD9:370.8",
          "MEDGEN:1268",
          "MESH:D015823",
          "MedDRA:10069408",
          "NCIT:C50450",
          "Orphanet:67043",
          "SCTID:231896005",
          "UMLS:C0000880",
          "icd11.foundation:49744193"
        ],
        "synonyms": [
          "Acanthamoeba caused keratitis",
          "keratitis, Acanthamoeba"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Keratitis due to infection by acanthamoeba; it is usually associated with soft contact lens wear, particularly overnight wear."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005629"
    },
    {
      "id": 7281,
      "label": "amebiasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9181",
          "EFO:0007144",
          "ICD10CM:A06",
          "ICD9:006",
          "ICD9:006.9",
          "MEDGEN:1857",
          "MESH:D000562",
          "NCIT:C84551",
          "UMLS:C0002438"
        ],
        "definition": "A parasitic infectious disorder caused by amoebas. The parasite may cause colitis which is manifested with bloody diarrhea, abdominal pain, nausea and fever. In rare cases it may spread to the liver, brain and lungs."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005644"
    },
    {
      "id": 7296,
      "label": "babesiosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9643",
          "EFO:0007162",
          "GARD:0005878",
          "ICD10CM:B60.0",
          "ICD9:088.82",
          "MEDGEN:2523",
          "MESH:D001404",
          "MedDRA:10003965",
          "NCIT:C84581",
          "NORD:832",
          "Orphanet:108",
          "SCTID:21061004",
          "UMLS:C0004576",
          "icd11.foundation:1947003329"
        ],
        "synonyms": [
          "Babesia caused disease or disorder",
          "Babesia disease or disorder",
          "Babesia infectious disease",
          "babesiasis",
          "infection by Babesia",
          "piroplasmosis",
          "Babesia parasite infection",
          "Human babesiosis"
        ],
        "definition": "Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005661"
    },
    {
      "id": 7297,
      "label": "balantidiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        7333,
        21309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12386",
          "EFO:0007163",
          "GARD:0000809",
          "ICD10CM:A07.0",
          "ICD9:007.0",
          "MEDGEN:2540",
          "MESH:D001447",
          "MedDRA:10004080",
          "NCIT:C84583",
          "NORD:833",
          "Orphanet:1223",
          "SCTID:57725006",
          "UMLS:C0004692",
          "icd11.foundation:2090337975"
        ],
        "synonyms": [
          "balantidiosis",
          "ciliary dysentery",
          "B coli infection",
          "Balantidiases",
          "Balantidium coli infection",
          "Human balantidiasis",
          "large-intestinal infection with Balantidium coli"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Infection by parasites of the genus balantidium. The presence of Balantidium in the large intestine leads to diarrhea; dysentery; and occasionally ulcer."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005662"
    },
    {
      "id": 7336,
      "label": "coccidiosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2113",
          "EFO:0007212",
          "ICD9:007.2",
          "MEDGEN:3138",
          "MESH:D003048",
          "NCIT:C34493",
          "SCTID:62005008",
          "UMLS:C0009187"
        ],
        "synonyms": [
          "coccidiosis (& [intestinal])"
        ],
        "definition": "A parasitic infection caused by Coccidia. It affects livestock, birds and humans. In humans the parasite infests the intestinal tract and may cause watery diarrhea, abdominal pain, fever, nausea and vomiting."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005707"
    },
    {
      "id": 7570,
      "label": "theileriasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3733",
          "EFO:0007506",
          "ICD9:136.8",
          "MEDGEN:11763",
          "MESH:D013801",
          "SCTID:68771000",
          "UMLS:C0039753"
        ],
        "definition": "Infection of cattle, sheep, or goats with protozoa of the genus theileria. This infection results in an acute or chronic febrile condition."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005978"
    },
    {
      "id": 13060,
      "label": "leishmaniasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4516,
        23869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9065",
          "EFO:0005044",
          "GARD:0006881",
          "ICD10CM:B55",
          "ICD10WHO:B55",
          "ICD9:085",
          "ICD9:085.9",
          "MEDGEN:9714",
          "MESH:D007896",
          "MedDRA:10024198",
          "NCIT:C34767",
          "NORD:1895",
          "Orphanet:507",
          "SCTID:80612004",
          "UMLS:C0023281",
          "icd11.foundation:1082373067"
        ],
        "synonyms": [
          "cutaneous leishmaniasis (subtype)",
          "visceral leishmaniasis (subtype)"
        ],
        "definition": "Infectious disease that is transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0011989"
    },
    {
      "id": 21523,
      "label": "dientamoebiasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4516,
        21309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:946",
          "MEDGEN:41551",
          "MESH:D004030",
          "SCTID:67915005",
          "UMLS:C0012147"
        ],
        "synonyms": [
          "Dientamoeba caused disease or disorder",
          "Dientamoeba disease or disorder",
          "Dientamoeba infectious disease",
          "Dientamoebiases"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Gastrointestinal infection with organisms of the genus dientamoeba."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024608"
    }
  ],
  "roots": [
    {
      "id": 6859,
      "label": "parasitic infectious disease"
    }
  ]
}