{
  "id": 4468,
  "label": "ovarian Brenner tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002370",
  "properties": {
    "xrefs": [
      "DOID:2636",
      "GARD:0009397",
      "MEDGEN:1716777",
      "NCIT:C3872",
      "SCTID:254859006",
      "UMLS:C5234884"
    ],
    "synonyms": [
      "Brenner tumor",
      "Brenner tumour",
      "Brenner neoplasm of ovary",
      "Brenner neoplasm of the ovary",
      "Brenner tumor of ovary",
      "Brenner tumor of the ovary",
      "Brenner tumour of ovary",
      "Brenner tumour of the ovary",
      "ovarian Brenner neoplasm",
      "ovarian Brenner tumor",
      "ovary Brenner tumor",
      "ovary Brenner tumour",
      "benign ovarian Brenner tumor",
      "benign ovarian Brenner tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign, borderline, or malignant transitional cell neoplasm arising from the ovary. It constitutes between 1% and 2% of all ovarian neoplasms. The average age at presentation is about 50 years. Grossly it is usually unilateral, firm and white or yellowish. Microscopically it consists of solid and cystic nests of epithelial cells resembling transitional epithelium surrounded by an abundant stromal component of dense, fibroblastic nature."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4347,
      "label": "ovarian epithelial tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265,
        20309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2152",
          "ICD9:239.5",
          "MEDGEN:90969",
          "NCIT:C4381",
          "ONCOTREE:OVT",
          "SCTID:237057005",
          "UMLS:C0341823"
        ],
        "synonyms": [
          "epithelial neoplasm of ovary",
          "epithelial neoplasm of the ovary",
          "epithelial tumor of ovary",
          "epithelial tumor of the ovary",
          "epithelial tumour of ovary",
          "epithelial tumour of the ovary",
          "ovarian epithelial tumor",
          "ovarian surface epithelial-stromal tumor",
          "ovarian surface epithelial-stromal tumour",
          "ovarian surface-epithelial stromal neoplasm",
          "ovary epithelial neoplasm",
          "OVT",
          "ovary epithelial cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor."
      },
      "child_count": 22,
      "reference_id": "MONDO:0002229"
    },
    {
      "id": 21291,
      "label": "Brenner tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638,
        22962
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:9000/0",
          "MEDGEN:2345",
          "MESH:D001948",
          "NCIT:C39954",
          "ONCOTREE:BTOV",
          "UMLS:C0006160"
        ],
        "synonyms": [
          "Brenner tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A usually benign tumor composed of solid and cystic nests of epithelial cells resembling transitional epithelium; it is surrounded by an abundant stromal component that is dense and fibroblastic in nature."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024235"
    }
  ],
  "children": [
    {
      "id": 4927,
      "label": "malignant ovarian Brenner tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4468,
        18447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4217",
          "GARD:0023301",
          "ICDO:9000/3",
          "MEDGEN:90793",
          "NCIT:C4270",
          "UMLS:C0334495"
        ],
        "synonyms": [
          "malignant Brenner tumor of ovary",
          "malignant Brenner tumor of the ovary",
          "malignant Brenner tumour of ovary",
          "malignant Brenner tumour of the ovary",
          "malignant ovarian Brenner tumor",
          "ovarian Brenner tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the ovary and is characterized by the presence of an invasive malignant transitional cell component and nests of benign transitional cells in a fibrotic stroma. When the neoplasm is confined to the ovary, the prognosis is good."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002920"
    }
  ],
  "roots": [
    {
      "id": 4347,
      "label": "ovarian epithelial tumor"
    },
    {
      "id": 21291,
      "label": "Brenner tumor"
    }
  ]
}