{
  "id": 4420,
  "label": "opportunistic mycosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002312",
  "properties": {
    "xrefs": [
      "DOID:2473",
      "ICD9:117.9",
      "ICD9:118",
      "MEDGEN:508004",
      "SCTID:78999002",
      "UMLS:C0029119"
    ],
    "synonyms": [
      "opportunistic systemic mycoses"
    ],
    "definition": "A mycosis that arises from infection in an immunologically compromised host."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 4188,
      "label": "fungal infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1564",
          "ICD10CM:B35-B49",
          "ICD9:110-118",
          "ICD9:117.9",
          "MEDGEN:6486",
          "MESH:D009181",
          "NCIT:C3245",
          "SCTID:3218000",
          "UMLS:C0026946"
        ],
        "synonyms": [
          "Fungi caused disease or disorder",
          "Fungi disease or disorder",
          "Fungi infection",
          "Fungi infectious disease",
          "mycosis",
          "fungal infection",
          "infection, fungal",
          "infections, Fungi"
        ],
        "definition": "An infection caused by a fungus."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002041"
    }
  ],
  "children": [
    {
      "id": 4043,
      "label": "phaeohyphomycosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420,
        23280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14049",
          "ICD9:117.8",
          "MEDGEN:452374",
          "MESH:D060446",
          "SCTID:47158003",
          "UMLS:C0276721",
          "icd11.foundation:547567937"
        ],
        "synonyms": [
          "infection by dematiacious fungi [Phaehyphomycosis]"
        ],
        "definition": "An opportunistic fungal infection caused by any of a variety of normally saprophytic fungi with hyaline hyphal elements. For example, Fusarium spp. infect neutropenic patients to cause pneumonia, fungemia, and disseminated infection with cutaneous lesions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001867"
    },
    {
      "id": 4173,
      "label": "candidiasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1508",
          "ICD10CM:B37",
          "ICD10WHO:B37",
          "ICD9:112",
          "ICD9:112.89",
          "ICD9:112.9",
          "MEDGEN:14299",
          "MESH:D002177",
          "NCIT:C26711",
          "SCTID:78048006",
          "UMLS:C0006840"
        ],
        "synonyms": [
          "Candida <Debaryomycetaceae> infection",
          "Candida infection",
          "Candidosis",
          "thrush",
          "disseminated candidiasis",
          "systemic candidiasis",
          "infections, Candida <Debaryomycetaceae>"
        ],
        "definition": "Infection with the organism Candida."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002026"
    },
    {
      "id": 6380,
      "label": "maple bark strippers' lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420,
        7386,
        18069,
        20956
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8484",
          "GARD:0024073",
          "ICD10CM:J67.6",
          "ICD9:495.6",
          "MEDGEN:510126",
          "SCTID:86638007",
          "UMLS:C0155890"
        ],
        "synonyms": [
          "alveolitis due to cryptostroma corticale",
          "maple bark-strippers' lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A hypersensitivity pneumonitis associated with the inhalation of fungal spores of Cryptostroma corticale in workers stripping the bark from maple and sycamore logs affected by sooty bark disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004584"
    },
    {
      "id": 7292,
      "label": "aspergillosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:1988-4002",
          "DOID:13564",
          "EFO:0007157",
          "GARD:0005856",
          "ICD10CM:B44",
          "ICD10WHO:B44",
          "ICD9:117.3",
          "MEDGEN:13939",
          "MESH:D001228",
          "MedDRA:10003488",
          "NCIT:C2886",
          "NORD:814",
          "Orphanet:1163",
          "SCTID:65553006",
          "UMLS:C0004030",
          "icd11.foundation:1913468488"
        ],
        "definition": "Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005657"
    },
    {
      "id": 7352,
      "label": "cryptococcosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4420,
        6859
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12053",
          "EFO:0007229",
          "GARD:0006218",
          "ICD10CM:B45",
          "ICD10WHO:B45",
          "ICD9:117.5",
          "MEDGEN:8189",
          "MESH:D003453",
          "MedDRA:10011490",
          "NCIT:C2967",
          "NORD:1019",
          "Orphanet:1546",
          "SCTID:42386007",
          "UMLS:C0010414",
          "icd11.foundation:390527954"
        ],
        "synonyms": [
          "Cryptococcus neoformans caused disease or disorder",
          "Cryptococcus neoformans disease or disorder",
          "Cryptococcus neoformans infectious disease",
          "torulosis"
        ],
        "definition": "An acute or chronic, localized or disseminated infection by Cryptococcus neoformans. Sites of involvement include the lungs, central nervous system and meninges, skin, and visceral organs.--2004"
      },
      "child_count": 2,
      "reference_id": "MONDO:0005724"
    },
    {
      "id": 7392,
      "label": "geotrichosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2832",
          "ICD10CM:B48.3",
          "ICD9:117.9",
          "MEDGEN:42202",
          "MESH:D005847",
          "SCTID:13969006",
          "UMLS:C0017455",
          "icd11.foundation:1432903072"
        ],
        "definition": "Infection due to the fungus Geotrichum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005772"
    },
    {
      "id": 7458,
      "label": "microsporidiosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4420,
        6859
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4271",
          "EFO:0007366",
          "GARD:0003655",
          "ICD9:117.9",
          "MEDGEN:39278",
          "MESH:D016881",
          "MedDRA:10053982",
          "NCIT:C84891",
          "Orphanet:2552",
          "SCTID:699676006",
          "UMLS:C0085407",
          "icd11.foundation:1021483422"
        ],
        "synonyms": [
          "Microsporidia caused disease or disorder",
          "Microsporidia disease or disorder",
          "Microsporidia infection",
          "Microsporidia infectious disease",
          "infection by Microspora",
          "Microsporidiasis"
        ],
        "definition": "A fungal infection caused by Microsporidia. It occurs in immunocompromised patients, causing diarrhea and wasting."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005846"
    },
    {
      "id": 16942,
      "label": "fusariosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050289",
          "EFO:1001795",
          "GARD:0020570",
          "MEDGEN:452375",
          "MESH:D060585",
          "MedDRA:10051919",
          "Orphanet:228119",
          "SCTID:64250002",
          "UMLS:C0276758",
          "icd11.foundation:565900954"
        ],
        "synonyms": [
          "Fusarium caused disease or disorder",
          "Fusarium disease or disorder",
          "Fusarium infection",
          "Fusarium infectious disease"
        ],
        "definition": "Fusariosis describes a superficial, locally invasive, disseminated infection with the pathogenic fungus species, Fusarium, often found in soil and water, which is mainly transmitted to humans through traumatic inoculation and that manifests with keratitis, onychomycosis and less frequently peritonitis and cellulitis. In the immunocompromised, disseminated fusariosis is more common and it manifests with refractory fever, skin lesions (ecthyma-like, target, and multiple subcutaneous nodules), severe myalgias and sino-pulmonary infections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016426"
    },
    {
      "id": 19003,
      "label": "pneumocystosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420,
        6953,
        7386,
        7525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11339",
          "EFO:0007448",
          "GARD:0004386",
          "ICD10CM:B59",
          "ICD9:136.3",
          "MEDGEN:777048",
          "MESH:D011020",
          "NCIT:C3334",
          "NORD:1923",
          "Orphanet:723",
          "SCTID:415125002",
          "UMLS:C1535939",
          "icd11.foundation:404370038"
        ],
        "synonyms": [
          "PCP",
          "PJP",
          "Pneumocystis",
          "Pneumocystis Pneumonia",
          "Pneumocystis carinii pneumonia",
          "Pneumocystis jirovecii pneumonia",
          "Pneumocystis pneumonia",
          "pneumocystosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019121"
    },
    {
      "id": 19015,
      "label": "Zygomycosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8485",
          "EFO:0007380",
          "GARD:0010224",
          "ICD10CM:B46",
          "ICD10WHO:B46",
          "ICD9:117.7",
          "MEDGEN:12207",
          "MESH:D009091",
          "MESH:D020096",
          "MedDRA:10028098",
          "MedDRA:10061418",
          "NCIT:C77212",
          "NORD:1946",
          "Orphanet:73263",
          "SCTID:59277005",
          "SCTID:76627001",
          "UMLS:C0043541",
          "icd11.foundation:1676389165"
        ],
        "synonyms": [
          "Mucormycosis",
          "Zygomycota infectious disease",
          "mucormycosis"
        ],
        "definition": "Any infection due to a fungus of the Zygomycota phylum. The disease typically involves the rhino-facial-cranial area, lungs, gastrointestinal tract, skin, or less commonly other organ systems. The infecting fungi have a predilection for invading vessels of the arterial system, causing embolization and subsequent necrosis of surrounding tissue."
      },
      "child_count": 1,
      "reference_id": "MONDO:0019136"
    },
    {
      "id": 23522,
      "label": "opportunistic systemic mycosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2801,
        4420
      ],
      "type_id": 0,
      "properties": {
        "definition": "A mycosis that arises from infection in an immunologically compromised host and is systemic."
      },
      "child_count": 6,
      "reference_id": "MONDO:0045033"
    },
    {
      "id": 23525,
      "label": "hyalohyphomycosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:452455",
          "MESH:D060605",
          "SCTID:240773008",
          "UMLS:C0343952"
        ],
        "synonyms": [
          "hyalohyphomycosis"
        ],
        "definition": "An opportunistic infection caused by a heterogeneous group of mitosporic fungi with clear (hyalo-) hyphae in the host. Common causative agents include acremonium; aspergillus; chrysosporium; fusarium; paecilomyces; penicillium; pseudallescheria; scedosporium; and scopulariopsis. Normally a dermatomycoses, it can become invasive in the immunocompromised host."
      },
      "child_count": 0,
      "reference_id": "MONDO:0045037"
    }
  ],
  "roots": [
    {
      "id": 4188,
      "label": "fungal infectious disease"
    }
  ]
}