{
  "id": 4278,
  "label": "hypogonadism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002146",
  "properties": {
    "xrefs": [
      "DOID:1924",
      "ICD9:253.4",
      "MEDGEN:5711",
      "MESH:D007006",
      "NCIT:C9227",
      "SCTID:48130008",
      "UMLS:C0020619"
    ],
    "synonyms": [
      "gonadotropin deficiency",
      "hypogonadotropism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4375,
      "label": "gonadal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2277",
          "MEDGEN:9074",
          "MESH:D006058",
          "NCIT:C26786",
          "UMLS:C0018050"
        ],
        "synonyms": [
          "disease of gonad",
          "disease or disorder of gonad",
          "disorder of gonad",
          "disorder of gonads",
          "gonad disease",
          "gonad disease or disorder",
          "gonadal disorder",
          "gonadal disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the testis or the ovary."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002259"
    }
  ],
  "children": [
    {
      "id": 4130,
      "label": "gonadal dysgenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4278
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14447",
          "GARD:0002538",
          "ICD9:758.6",
          "MEDGEN:9075",
          "MESH:D006059",
          "NCIT:C61420",
          "SCTID:205681004",
          "UMLS:C0018051"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A congenital disorder characterized by the presence of extremely hypoplastic gonads preventing the development of secondary sex characteristics."
      },
      "child_count": 5,
      "reference_id": "MONDO:0001967"
    },
    {
      "id": 7379,
      "label": "eunuchism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4278
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5003",
          "EFO:0007266",
          "ICD9:257.2",
          "MEDGEN:65949",
          "MESH:D005058",
          "NCIT:C131195",
          "SCTID:267403002",
          "UMLS:C0238117"
        ],
        "synonyms": [
          "Primary testicular failure",
          "Male hypergonadotropic hypogonadism",
          "hypergonadotropic hypogonadism (Male)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The state of being a eunuch, a male without testes or whose testes failed to develop. It is characterized by the lack of mature male germ cells and testicular hormones."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005758"
    },
    {
      "id": 10652,
      "label": "hypogonadism, male",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4278,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:257.2",
          "MEDGEN:57480",
          "OMIM:241100",
          "SCTID:48723006",
          "UMLS:C0151721"
        ],
        "synonyms": [
          "hypogonadism, male",
          "hypogonadism and testicular atrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0009421"
    },
    {
      "id": 18569,
      "label": "hypogonadotropic hypogonadism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4278,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0090070",
          "DOID:7455",
          "GARD:0016533",
          "HP:0000044",
          "ICD9:253.4",
          "MEDGEN:82883",
          "NANDO:1200388",
          "NANDO:2100138",
          "NANDO:2200382",
          "NCIT:C113347",
          "OMIMPS:147950",
          "Orphanet:432",
          "SCTID:33927004",
          "UMLS:C0271623"
        ],
        "synonyms": [
          "Normosmic idiopathic hypogonadotropic hypogonadism",
          "central hypogonadism",
          "gonadotropic deficiency",
          "hypogonadism, hypogonadotropic",
          "hypogonadotropic hypogonadism",
          "hypogonadotropic hypogonadism with or without anosmia",
          "low gonadotropins (secondary hypogonadism)",
          "nIHH",
          "normosmic congenital hypogonadotropic hypogonadism",
          "secondary hypogonadism",
          "congenital idiopathic hypogonadotropic hypogonadism",
          "isolated congenital gonadotropin deficiency",
          "hypogonadotropism",
          "isolated hypogonadotropic hypogonadism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis."
      },
      "child_count": 20,
      "reference_id": "MONDO:0018555"
    },
    {
      "id": 23089,
      "label": "Slti-Salem syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4278,
        4370,
        6660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025851",
          "MEDGEN:419036",
          "MESH:C536673",
          "UMLS:C2931284"
        ],
        "synonyms": [
          "Slti Salem syndrome",
          "hypogonadism and frontoparietal alopecia",
          "hypogonadotropic hypogonadism alopecia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0042962"
    },
    {
      "id": 23115,
      "label": "weinstein kliman scully syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4278,
        4370,
        18954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000392",
          "MEDGEN:419765",
          "MESH:C536688",
          "UMLS:C2931289"
        ],
        "synonyms": [
          "cardiomyopathy, hypogonadism and metabolic anomalies",
          "primary testicular insufficiency with normal virilization, blindness, deafness and metabolic abnormalities"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043077"
    }
  ],
  "roots": [
    {
      "id": 4375,
      "label": "gonadal disorder"
    }
  ]
}